The Organoid and Tissue Modeling Shared Resource (OTMSR) is an institutional, fee-for-service core facility supporting advanced organoid technologies on campus. The OTMSR provides researchers with access to state-of-the art organoid and gene editing technologies and expert technical support to utilize novel in vitro 3D organoid model systems for basic and translational research.
Currently, the OTMSR provides organoid services to:
Organoids are defined as “self-organizing three dimensional (3D) structures grown from stem cells which mimic the in vivo architecture and multi-lineage differentiation of the original tissue.” Organoids can be derived from two types of stem cells: (i) pluripotent stem cells (PSCs) or (ii) adult tissue-derived somatic stem cells.
PSC-derived organoids recapitulate developmental programming and have the potential to form tissue/organ structures through processes that occur during development.
Tissue-derived somatic organoids recapitulate adult tissue repair mechanisms rather than development and in general, only tissues that exhibit some regenerative capacity are amenable to this approach.
The overall mission of the OTMSR is to facilitate access, generation and usage of novel in vitro mouse and human organoid systems to promote innovative basic and translational research and disease modeling. To help overcome the obstacles faced by basic scientists and clinical researchers who wish to establish these approaches in their labs, we will provide expertise, resources, and training in these start-of-the-art technologies together with standardization for protocols, subsidized reagents and validated organoid lines. This will be achieved in five ways:
Barbara Davis Center
1775 Aurora Court
M20 - 3202N
Aurora, CO 80045
Hours | 9:00 am - 5:00 pm
Lab Phone | 303-724-8235
|Peter Dempsey, PhD||OTMSR@cuanschutz.edu||303-724-5602|
|Sean McGrath, PhD||OTMSR@cuanschutz.edu||303-724-8235|