The Section of Developmental Biology at the University of Colorado is committed to research that improves child health. Specifically, we have five main objectives:

  • Understand the genetic, molecular and cellular mechanisms that guide normal development
  • Determine how normal developmental processes are altered to result in developmental disease and disability
  • Identify new diagnostic strategies and molecular and cellular therapies targeted at treatment of childhood disease
  • Train the next generation of leaders in developmental and stem cell biology and pediatric disease research
  • Serve as a hub for basic and translational child health research that spans the Anschutz Medical Campus research community

To accomplish these objectives the faculty, graduate students, postdoctoral trainees and research staff who comprise the Section of Developmental Biology perform research using stem cell, organoid and animal experimental models, including Drosophila, zebrafish and mice. Our investigations focus on several major tissue and organ systems such as the brain, heart, intestine, face and vascular, olfactory and immune systems. Our work is leading to a better understanding of childhood disabilities associated with neuropsychiatric disease, Down syndrome, the congenital basis of cardiovascular and facial malformations and the impact of maternal health on fetal development.

Prdm8 regulates pMN progenitor specification for motor neuron and oligodendrocyte fates by modulating the Shh signaling response

Prdm8 suppresses Shh response in pMN progenitors to inhibit oligodendrocyte specification. Loss of prdm8 function in zebrafish leads to a deficit in motor neurons and an excess of oligodendrocytes that is due to premature oligodendrocyte formation.

Kayt ScottRebecca O'RourkeAustin GillenBruce Appel

August 27, 2020

Graphical representation Scott