The Section of Developmental Biology at the University of Colorado is committed to research that improves child health. Specifically, we have five main objectives:
To accomplish these objectives the faculty, graduate students, postdoctoral trainees and research staff who comprise the Section of Developmental Biology perform research using stem cell, organoid and animal experimental models, including Drosophila, zebrafish and mice. Our investigations focus on several major tissue and organ systems such as the brain, heart, intestine, face and vascular, olfactory and immune systems. Our work is leading to a better understanding of childhood disabilities associated with neuropsychiatric disease, Down syndrome, the congenital basis of cardiovascular and facial malformations and the impact of maternal health on fetal development.
Prdm8 suppresses Shh response in pMN progenitors to inhibit oligodendrocyte specification. Loss of prdm8 function in zebrafish leads to a deficit in motor neurons and an excess of oligodendrocytes that is due to premature oligodendrocyte formation.
, , ,
August 27, 2020
John DeSisto, Rebecca O’Rourke, Hannah E. Jones, Bradley Pawlikowski, Alexandra D. Malek, Stephanie Bonney, Fabien Guimiot, Kenneth L. Jones, Julie A. Siegenthaler
Alexandria N. Hughes, Bruce Appel
Natacha Bohin, Theresa M. Keeley, Alexis J. Carulli, Emily M. Walker, Elizabeth A. Carlson, Jie Gao, Iannis Aifantis, Christian W. Siebel, Michael W. Rajala, Martin G. Myers Jr, Jennifer C. Jones, Constance D. Brindley, Peter J. Dempsey, Linda C. Samuelson