The Disease Modeling Core (DM core) provides diabetes researchers with access to novel human stem cell-derived in vitro cell models for investigating cellular and molecular features of both Type 1 and Type 2 diabetes. Recent progress in stem cell, organoid culture, gene editing and directed differentiation technologies has afforded opportunities to develop state-of-the-art pre-clinical human models.The goal of DM core is to provide the expertise, infrastructure and access to novel human model systems and technologies to DRC investigators. This includes expertise, resources and training in start-of-the-art stem cell technologies together with rigorous quality control testing, validation standardization and authentication all model platforms and reagents.