Center MemberTitleDepartmentResearch KeywordsResearch Summary
 Akturk, Halis, PhD Assistant ProfessorPediatrics-Barbara Davis Center Diabetes mellitus, Type 1, blood glucose, blood glucose self-monitoring, hypoglycemic agents, diabetes mellitus, Type 2Dr. Aturk’s research is focused on immune checkpoint inhibitor-induced type 1 diabetes.  While immune checkpoint inhibitors are very effective in cancer treatment, their effect is not only limited to tumor cell and they have many autoimmune side effects. One of the permanent endocrine side effects is type 1 diabetes. A goal of Dr. Akturk's lab is to identify risk factors to develop diabetes and develop screening algorithms to prevent morbidity and mortality related to diabetic ketoacidosis and understand PD-1 pathway in possible prevention of the development of childhood onset type 1 diabetes.
Albers, David PhDAssociate ProfessorPediatrics - Informatics & Data ScienceMachine learning, Mathematical models of physiology, inference methods, Data analysis, Mining methods, artificial pancreas, T2DDr. Albers is a biomedical informatician with a PhD in mathematical physics. Dr. Albers develops mathematical models of physiology, machine learning models, and their associated inference methods to support the extraction and creation of new knowledge from data related to diabetes, to support clinician-centric decision support, and to support patient-centric decision support for chronic disease self-management. He also works with model-based control, e.g., like the artificial pancreas project, but in the context of type-2 diabetes, cystic fibrosis related diabetes, and within the intensive care unit unrelated to diabetes. 
Alonso, G. Todd, MDAssociate ProfessorPediatrics- Barbara Davis Center Diabetes mellitus Type 1, diabetic ketoacidosis, Graves disease, glycated hemoglobin A, insulin infusion systemsDr. Alonso’s primary academic interest is redesigning the system in which care is provided to children and adolescents with type 1 diabetes. He leads multiple quality improvement initiatives which help evolve the delivery of diabetes care, including automatically providing patients with a personalized sick day action plan at each visit, designing sick day teaching materials, and developing the "Extra Care" program to provide extra assistance for approximately 500 families in scheduling and attending clinic encounters. In 2020, he co-led the development of a COVID-19 registry for the T1D Exchange which has published and submitted several manuscripts describing the experience of US patients with T1D who experience COVID-19.
Baker, Rocky, PharmDResearch Assistant ProfessorImmunology & MicrobiologyCD4 positive T-lymphocytes, autoantigens, islet amyloid polypeptide, diabetes Type 1The focus of Dr. Baker’s research is to understand how islet-reactive CD4 T cells are activated in the context of T1D. His work has ranged from exploring the mechanisms contributing to T cell effector function to investigating the role of new beta-cell autoantigens. The discovery and characterization of new antigens implicated in the pathogenesis of T1D is a high priority as it can lead to new diagnostic tools and anticipate that studies proposed by Dr. Baker will provide critical information to target autoreactive T cells though antigen-specific therapies.
Bates, Emily PhD Associate ProfessorPediatricsPancreas development, fetal exposuresDr. Bates studies how the activity of ion channels affects fetal development. In particular, we are interested in how fetal exposure to substances like cannabidiol (CBD) impact pancreas development and function to induce glucose intolerance. 
Benninger, Richard, PhDAssociate ProfessorBioengineeringIslets of Langerhans, cell-cell communication, insulinDr. Benninger’s research focuses on understanding the mechanisms underlying pancreatic islet function and decline in type1 and type2 diabetes. A major focus has been understanding the role of intra-islet communication and functional sub-populations of cells in islet function, and how disruption to intra-islet communication mechanisms and changes in sub-populations occur in diabetes and may contribute to islet decline.  Complimentary to these studies, Dr Benninger’s lab is also developing ultrasound-based imaging diagnostics for non-invasively detecting islet decline in pre-symptomatic diabetes and as a platform for image-guided drug delivery.
Berg, Leslie, PhDProfessor and ChairImmunology & MicrobiologyCD8-Positive T-lymphocytes, cell differentiation, T-lymphocytes,The focus of Dr. Berg's work is on the signaling proteins and pathways regulating T lymphocyte development, differentiation, activation, and migration, with a strong emphasis on T-cell receptor (TCR) signaling. Her work on the T cell tyrosine kinase ITK has revealed a critical role for this TCR signaling protein in autoreactive T cell trafficking into tissues such as the pancreas and the intestine. She is currently engaged in efforts to identify allosteric inhibitors of ITK that could be used in combination with active site kinase inhibitors to target ITK and thereby interfere with autoimmune T cell infiltration. A goal of this project is to block the progression of islet inflammation in Type I diabetes-susceptible individuals.
Bergman, Bryan, PhDProfessorMedicine-Endocrinology, Metabolism and DiabetesMuscle insulin resistanceDr. Bergman’s research investigates the relationship between muscle lipids and insulin sensitivity. His laboratory focuses on the relationship between skeletal muscle subcellular lipid localization and insulin resistance in humans, and how intermuscular adipose tissue impacts skeletal muscle insulin sensitivity, muscle strength, and size in humans. The overall goal of Dr. Bergman’s research is to uncover novel therapeutic targets to increase muscle insulin sensitivity, a need not met by currently therapies, to help prevent and treat pre-diabetes and type 2 diabetes.
Bergouignan, Audrey, PhDAssistant ProfessorMedicine-Endocrinology, Metabolism and DiabetesEnergy metaboloism, bed rest, exercise, dietary fatsDr. Bergouignan’ research focuses on the study of energy balance and metabolic flexibility, and their regulation by environmental factors, i.e. physical activity, sedentary behaviors and diet. She aims to (i) understand the mechanisms by which sedentary behaviors and physical inactivity contribute to the development and progression of metabolic diseases including type 2 diabetes, obesity and metabolic syndrome, (ii) test and implement in daily life preventive strategies of sedentary behaviors and associated metabolic diseases. Her approach is interdisciplinary and translational, and aims to provide objective evidence to help refining future public health guidelines on physical activity and thus help combating the type 2 diabetes and obesity epidemic. 
Bessesen, Daniel, MDProfessorMedicine- Endocrinology, Metabolism and DiabetesEnergy metabolism, obesity, dietary fats, energy intake, body weightDr. Bessesen’s research focuses on understanding the physiology of body weight regulation and also the clinical treatment of obesity. Human physiological studies done by his group are designed to understand the mechanisms that promote or protect against weight gain. They have studied the effects of over and underfeeding as well as the effects of exercise in constitutively thin, obese and reduced obese men and women.  Recent work has focused on how diurnal metabolism/hormone profiles and clock gene expression in adipose tissue respond to daytime overfeeding or exercise. 
Bethea, Maigen PhDResearch InstructorPediatricsObesity, mechanosensation,vagal afferents, gut-brain communicationMaigen Bethea, PhD, is a Research Instructor at the University of Colorado Anschutz Medical Campus. She is currently interested in the impact of sex on obesity and diabetes as these diseases are distinct in incidence and in regulatory pathways between men and women. 80% of patients that receive bariatric surgery are women. Dr. Bethea's current work on the impact of biological sex on the role of the gut-brain-axis in response to surgery is translationally relevant. Her long-term academic goal is to become an expert on the impact of sex on the role of the gut-brain-pancreas axis in regulating glucose metabolism. 
Blaine, Judith  MD PhDProfessorMedicineProteinuria, podocytes, FcRn, immune-mediated kidney diseaseTo understand the mechanisms involved in podocyte handling of serum proteins such as albumin and IgG as well as immune complexes to develop targeted therapies to treat proteinuric and immune-mediated kidney diseases.
Boyle, Kristen, PhDAssociate ProfessorPediatrics- NutritionObesity, skeletal muscle, adipocytes, lipid metabolism, insulin resistance, gestational diabetes, developmental programmingThe major goal of Dr. Boyle’s research program is to identify and understand how maternal exposures in pregnancy may alter offspring phenotype in humans. Her research aims to determine the epigenetic regulation of phenotype differences in infants born to mothers with obesity or other potentially adverse exposures using mesenchymal stem cells derived from human umbilical cord tissue.
Broussard, Josiane, PhDAssistant ProfessorMedicine- Endocrinology, Metabolism and DiabetesInsulin resistance, sleep deprivation, insulin, fatty acids nonesterifiedDr. Broussard is interested in understanding the role of sleep and circadian regulation in metabolic homeostasis. Specifically, she studies how sleep and circadian disruption impair metabolic tissues and whether countermeasures can be defined that improve metabolic health when these behaviors are unavoidable. Dr. Broussard directs the Sleep and Metabolism Laboratory at Colorado State University and is an active affiliated faculty member of the DEM&D and uses the Clinical and Translational Research Center at the University for her ongoing studies. 
Bruce, Kimberly PhDAssociate ProfessorDivision of Endocrinology, Metabolism and Diabetes Lipid and lipoprotein metabolism, Brain Metabolism, Glia, Macrophages, Lipoprotein Lipase, Neurodegenerative disease Dr. Kimberley Bruce has a long-standing interest in interrogating the molecular mechanisms regulating metabolism that are involved in the pathogenesis of human diseases. Her current research is focused on how changes in brain metabolism, particularly central lipid and lipoprotein processing, are involved in the neuropathogenesis of brain diseases such as Alzheimer's disease.
Brzezinski IV, Joseph A  PhDAssociate ProfessorOphthalmologyTranscription factors, retinal development, enhancers, cell therapy, retinal degenerative diseaseDr. Brzezinski's lab studies how mammalian retinas (mouse and human) develop. In particular, they investigate how gene regulatory networks control cell fate decisions during development. They are also using their knowledge of retinal development to help design cell-based therapies for blinding diseases, like macular degeneration and diabetic retinopathy.
Burchill, Matthew  PhDAssociate ProfessorMedicineImmunology, Metabolic Dysfunction, Steatohepatitis and T cellsOne of the main features of chronic infection in the liver is the appearance of tertiary lymphoid structures.  These structures contain T cells, B cells macrophages, high endothelial venules, and lymphatic vasculature.  As a result, we evaluated the contribution of the lymphatic system to immune homeostasis during chronic inflammation.  This collaboration led to our discovery that the loss of normal lymphatic function during chronic and acute liver disease prevents proper trafficking of proteins and immune cells from the liver.  This fruitful collaboration led to several publications focused on highlighting a novel role for the lymphatic system in liver health and disease, was the focus of a high-profile editorial, piqued the interest of both lymphatic and liver researchers at international meetings where the lab's work was presented our work on 4 separate occasions, and ultimately led to R01 funding.  This R01 has been a highly productive endeavor which has resulted in 2 first author publications, 2 senior author publication and multiple collaborative publications (PMIDs: 32961356, 34370798, 36338478, 34923085, 33207208, 34531850, 33883256) in the first three years of this award.   As with the lymphatic system in the liver, little is understood about the contribution of T cells to chronic liver disease.  As such, while immunotherapies have been developed for other chronic diseases such as cancer, arthritis and IBD, very few therapeutic options are available to individuals with advanced liver disease and many individuals must undergo liver transplantation.  Thus, our current work focuses on innovative approaches to better understand the contribution of immune cell infiltration, programming, and trafficking during the progression of liver disease, with the hopes of identifying novel therapeutic targets for a collection of diseases that directly result in over 40,000 yearly deaths in the U.S. alone.  
Chan, Christine L, MDAssistant ProfessorPediatrics - EndocrinologyGlucose monitoring, Type 2 diabetes, oral glucose tolerance, prediabetic youth, obese youth, cystic fibrosis, insulin sensitivityDr. Chan’s research in the area of type 2 diabetes screening in obese youth addresses questions surrounding the significance of extrapolating current American Diabetes Association (ADA) screening criteria from adults to youth. Dr. Chan is using continuous glucose monitoring to characterize early glucose abnormalities and their relationship with the oral glucose tolerance test, HbA1c, and alternate glycemic markers – fructosamine, glycated albumin, and 1,5-anhydroglucitol.  A major goal of Dr. Chan’s current research is to understand the impact of early glycemic abnormalities on clinical outcomes, including nutrition and pulmonary function.
Dabelea, Dana, MD/PhDProfessorEpidemiologyLifecourse epidemiology, diabetes, obesity, insulin resistance and maternal child healthDr. Dabelea's main research interest is understanding how early life behaviors, environmental exposures and other risk factors operating during fetal or early post-natal life, influence the development of obesity, diabetes and cardiovascular outcomes throughout the lifecourse (developmental origins of health and disease). Her experience includes epidemiological studies with community-based and clinic-based sampling, longitudinal follow-up, and extensive sample collection and storage. 
Dai, Shaodong, PhDAssociate professorSOP- Pharmaceutical SciencesCD-4-positive T-lymphocytesThe Dai lab’s research is focused on understanding the mechanisms of autoimmune diseases and will provide the molecular basis upon which we may be able to design therapeutic compounds to prevent or treat these diseases. His lab is studying how post-translational modification (PTM), e.g., peptide fusion, disulfide modification and chemical modifications can create T cell neoantigens in autoimmune diseases. The modified self-peptides create neoantigens and activate pathogenic T cells. These modifications may contribute to the pathogenesis of Type 1 diabetes (T1D). 
Davidson, Howard, PhDAssociate professorPediatrics- Barbara Davis Center Diabetes mellitus, Type 1, beta cells, T cells, autoantibodies, autoantigens The goal of research in the Davidson laboratory is to develop improved biomarkers of type 1 diabetes (T1D), identify new therapeutic targets for the prevention and/or treatment of T1D, and ultimately to translate this research to the clinic. His research focuses on 2 major areas - 1) the immunology of T1D, and 2) the cell biology of pancreatic beta cells, with special emphasis on diabetes autoantigens. Current projects include development of novel bioassays for monitoring disease relevant T-cells in peripheral blood, and analysis of stress-induced changes to the beta cell proteome that may create neo-autoantigens.
Davis, Shanlee, MDAssistant professorPediatrics - EndocrinologyAdiposity in infants, inpatient hypoglycemia prevention, complications of DKA, cardiometabolism in sex chromosome aneupliodiesDr. Davis studies insulin resistance and energy metabolism in children with genetic syndromes that confer an increased risk for type 2 diabetes and similar disorders. In particular, she is interested in the interplay between hypogonadism in these populations, including Klinefelter and Turner syndromes, and the development of insulin resistance. Her current protocols seek to further investigate the non-obesity-related mechanisms that contribute to insulin resistance and the high risk of type 2 diabetes in this population.  She uses novel methods to assess in vivo mitochondrial function in this cohort, with plans to extend to other populations with hypogonadism at high risk for type 2 diabetes.   
Delong, Thomas, PhDAssistant ProfessorImmunology & MicrobiologyAutoantigens, CD4-Positive T-Lymphocytes, islet amyloid polypeptide, diabetes mellitus Type1Dr. Delong is a protein chemist who works on the discovery of autoantigens that are targeted by autoreactive T cells in Type 1 Diabetes (T1D).  In collaboration with researchers at the Barbara Davis Center, Dr. Delong works on the detection of autoantigens in human and murine β-cells, the detection of autoreactive T cells obtained from new onset T1D patients and predisposed individuals, and the mechanism that leads to the formation of modified autoantigens.
Dempsey, Peter, PhDAssociate professorPediatrics- Gastroenterology, Hepatology & NutritionADAM Proteins, amyloid precursor protein secretases, membrane proteins, intercellular signaling peptides & proteinsA major goal of Dr. Dempsey’s diabetes research is to understand how ADAM-mediated signaling events are regulated in pancreatic beta cells during normal homeostasis and upon beta cell stress. The lab is also studying the regulation of enteroendocrine cell programming with the goal of understanding the relationship between specific enteroendocrine progenitors and stem cell maintenance. 
Diniz Behn, Cecilia, PhDAssociate ProfessorApplied Mathematics and Statisticsmathematical modeling, insulin sensitivity, beta cell function, sleep, circadianDr. Diniz Behn's research applies multiscale mathematical modeling to investigate key research questions in metabolism, sleep, circadian rhythms, and the diverse interactions among these systems. Her metabolic models focus on describing the dynamics of metabolites including glucose, glycerol, insulin, and C-peptide to quantify insulin sensitivity and beta cell function. These models have been developed and applied in the context of type 1 diabetes, type 2 diabetes, cystic fibrosis related diabetes, and polycystic ovary syndrome. Her sleep and circadian models focus on translating neurophysiology to observed sleep/wake behavior. Current research also includes investigating sleep and circadian-based therapeutic targets for interventions to improve glycemic control in adolescents.
Doran, Kelly  PhDProfessorImmunology and Microbiology bacterial infection, diabetic foot ulcersDr. Doran is a microbiologist with a broad background in microbiology and innate immunology with expertise working with a variety of bacterial pathogens including Streptococcus, Enterococcus, and Staphylococcus (MRSA). Specifically, her lab studies host - pathogen interactions and seeks to elucidate the mechanisms by which bacteria colonize the human host and penetrate tissue barriers in order to cause disease.  The lab has primarily focused on Group B Streptococcus (GBS), to understand colonization of the female reproductive tract, transmission to the newborn which can result in invasive disease such as meningitis, and more recently emerging wound infection in patients with diabetes. Using a variety of molecular genetic approaches, her research team seeks to discover and characterize bacterial virulence determinants involved in cytotoxicity, adherence, invasion, inflammation, molecular mimicry and resistance to immunologic clearance. She also investigates the contribution of host factors such as surface receptors, signal transduction pathways, and transcription factors in defense against invasive bacterial infection. Dr. Doran has successfully developed an independent research program and has a demonstrated record of successful and productive research projects at the interface of bacteriology, host cell biology and immunology. Dr. Doran also has a deep and sustained commitment to training the next generation of scientists and ensuring diversity, equity and inclusion. 
Farnsworth, Nikki, PhDAssistant professorPediatrics- Barbara Davis Center Islets of Langerhans, islet dysfunction, Type 1 diabetes mellitus, beta-cell death, biomaterialsDr. Farnsworth’s research program aims to use biomaterials as a tool to study β-cell dysfunction and death mechanisms in type 1 diabetes. Her goals for current research are to further the understanding of islet dysfunction and death mechanisms during the pathogenesis of type 1 diabetes, to understand the role of extracellular matrix interactions in the onset and progression of disease, and to develop therapies which preserve islet function and mass after the onset of disease, using biomaterials as a tool to facilitate this research. 
Flores-Bellver, Miguel PhDAssistant ProfessorOphthalmologyExosomes, Diabetic Retinopathy, Stem cells, biomarkersDr. Flores-Bellver's work focuses on identifying biomarkers for early detection of retinal diseases, particularly Diabetic Retinopathy (DR). Early-stage DR often lacks visible symptoms but can lead to serious vision loss in its late stages. Despite technological advances, early detection of DR remains challenging. Dr. Flores-Bellver's research investigates extracellular vesicles (EVs), which are released by all cells and contain disease-specific genetic material. Her initial studies have shown that miRNA and protein in EVs from DR-affected retinas can be detected in urine, providing a unique early DR signature. The ultimate goal is to create a panel of EV miRNA and proteins for early DR diagnosis and monitoring, offering a novel method to detect and stage the disease
Forlenza, Greg, MDAssistant professorPediatrics - EndocrinologyInsulin infusion systems, artificial pancreas, hypoglycemia, diabetes mellitus Type 1The major goal of Dr. Forlenza’s research program is to develop, test, and refine diabetes technology in a translational fashion from engineering theory to clinical applications. Dr. Forlenza works primarily on clinical research involving continuous glucose monitors, insulin pumps, and artificial pancreas systems. Dr. Forlenza recently received a JDRF early career award to study why patients discontinue advanced technology and behavioral interventions to promote sustained use with new technology.
Francis, Prashanth MD PhDAssistant ProfessorDepartment of Medicine, Division of Gastroenterology and HepatologyCAR T cells, Cellular Therapies, Autoimmunity, T cells, T cell receptorDr. Francis is a physician-scientist who works in developing novel cellular therapies for autoimmune diseases. He has developed chimeric antigen receptor (CAR) platforms to address autoimmunity driven by T cells. He currently works in mouse models of type 1 diabetes to demonstrate proof of concept that these technologies can be used to prevent and/or improve the course of type 1 diabetes. 
Friedman, Rachel, PhDAssociate professorImmunology & Microbiology, Barbara Davis CenterT-lymphocytes, antigen-presenting cells, myeloid cells, cell communication, cell movement, autoantigens, in vivo imagingThe focus of Dr. Friedman’s research is to understand how cellular and environmental factors within the pancreatic islets regulate the autoimmune response during type 1 diabetes. Currently much of her research focuses on mechanisms by which islet myeloid cells regulate the autoimmune T cell response with a focus on in vivo readouts such as imaging of cellular dynamics and interactions. 
Fujita, Mayumi , MD PhDProfessor and Vice Chair of Research, DermatololgyDermatology (primary) and Immunology/Microbiology (secondary)Treg cells, IL-37, autoimmunity, adoptive therapy, toleranceEvidence supports that type 1 diabetes (T1D) is caused by an immune-mediated attack of pancreatic beta cells and that an inappropriate balance between pathogenic T cells and regulatory T (Treg) cells impairs peripheral tolerance. Many researchers have tried to enhance the number and functionality of Treg cells in T1D, but to date, clinical trials using an adoptive Treg infusion have shown ineffective. Our research lab found that IL-37 plays an important role in human Treg cells. Therefore, we are examining the role of IL-37 expression in Treg cells of T1D using animal models and T1D patient blood samples. 
Getahun, Andrew, PhDResearch Assistant professorImmunology & MicrobiologyB-lymphocyte, b-lymphocyte subsets, immunoglobins, autoimmune disease, autoimmunity, signal transductionA major goal of Dr. Getahun’s research program is to understand the mechanisms by which autoreactive B cells are tolerized in healthy individuals, and to determine the mechanisms by which genetic and environmental factors compromise B cell tolerance in patients developing autoimmune disease, such as Type 1 diabetes. He recently defined several inhibitory signaling feedback loops that are important for maintaining B cell tolerance and is currently studying the influence of known systemic lupus erythematous (SLE) risk alleles on the ability of autoreactive B cells to initiate and maintain these required inhibitory feedback loops. In addition, he has begun studies to determine if these inhibitory feedback loops are important in maintaining tolerance of insulin-specific B cells.
Gottlieb, Peter, MDProfessorPediatrics- Barbara Davis Center Diabetes mellitus Type 1, insulin, autoantibodies, hypoglycemic agents, insulin-secreting cellsDr. Gottlieb has worked in the fields of autoimmunity, type 1 diabetes, and other endocrine disorders (Addison’s Disease and APS2) for over 25 years.  His research initially focused on the role of T cells in mediating autoimmunity, but has expanded to appreciate the diverse immune and metabolic processes which underlie the development of autoimmunity and subsequent end-organ failure.  Recently, his interests have become more translational, with a focus on clinical trials as a means to better understand and treat the autoimmune condition at the heart of these disorders. 
Gutierrez-Colina, Ana, PhDAssistant ProfessorEndocrinology (CHCO), Human Dev & Family Studies (Colorado State University)T2D, health behavior, adherence, underserved, teens, interventionDr. Gutierrez-Colina is a health behavior research scientist, with expertise in pediatric adherence and health self-management. Broadly, her programmatic line of research is focused on health promotion and self-management in youth with and at risk for chronic disease and associated comorbidities. Dr. Gutierrez-Colina's interests lie at the intersection of neurobehavioral and contextual factors that underlie mechanisms related to health behavior and health behavior change, particularly among minoritized youth disproportionally affected by adversity. She is particularly interested in the role of modifiable adherence barriers and how they can be effectively altered through tailored behavioral interventions to improve youth's well-being and health outcomes.
Haskins, Katie, PhDProfessorImmunology & MicrobiologyAutoantigens, Diabetes Mellitus Type 1, CD4-Positive T-lymphocytes, Inbred NOD mice, islets of LangerhansThe overall research focus of the Haskins laboratory over the past 25 years has been the investigation of pathogenic and regulatory processes mediated by CD4 T cells in type 1 diabetes (T1D), and the identification of new autoantigens for diabetogenic T cells. Recent progress has led to the successful identification of two new secretory granule proteins as autoantigens for CD4 T cells: chromogranin A (ChgA) and islet amyloid polypeptide (IAPP). In addition, the Haskin’s lab is developing new hybrid peptide tetramer reagents to detect autoreactive T cells, and investigating whether hybrid peptides could be used to induce antigen-specific tolerance. Current goals involve moving these studies into the translational arena to identify and characterize autoreactive T cells in human subjects with T1D. 
Hernandez, Teri, PhD/RNProfessor, Associate Dean for Research and ScholarshipNursing, Medicine/EndocrinologyGestational diabetes, nutrition therapy, blood glucose, glycemic index, fat-restricted dietDr. Hernandez has a vision to advance clinical care in the prevention of cardiovascular disease and diabetes in women and their families.  She has a broad interest in women’s health and a particular interest in the physiology of insulin resistance, as both an adaptive mechanism and as pathology, and in its evolution as a determinant of long-term health. She seeks to establish clinical investigations across the lifespan in women and their offspring to better understand insulin resistance, diabetes, and cardiovascular disease risk.  She has focused on glucose and lipid metabolism during pregnancy and understanding in-utero programming influences, such as diet, that enhance or attenuate CVD and diabetes risk. Aspects of cardiovascular disease and diabetes risk that are of special interest include insulin resistance, gestational diabetes, lipids and lipid metabolism, obesity and fat metabolism. 
Hill, Jennifer  PhDAssistant ProfessorMolecular Cellular Developmental Biologymicrobiome, neonatal, islet development, gnotobioticsMicrobial organisms are capable of producing a vast array of products, most of which are unknown. This untapped source of novel molecules could be harboring therapies and cures for human diseases. During her postdoctoral training, Dr. Hill uncovered a network of host-microbe interactions that can influence normal development of the endocrine pancreas. In this work she, we've found evidence for both bacterial and fungal mechanisms that stimulate increased beta-cell mass during host development. Importantly work in the Hill Lab highlights that a collection of unique microbial stimulants have effects on postnatal developmental processes that impact later life metabolic health and disease, emphasizing the importance of harboring functional diversity within the early-life microbiota. This is particularly relevant given the high use of antibiotics and antifungals in infants and children, which significantly impact overall microbiota composition. Dr. Hill's work indicates that losing important microbial taxa in early life, could result in lifelong consequences for our health. The Hill lab will focuses on understanding how postnatal tissue differentiation and homeostasis are governed by the natural flux of signaling ligands produced by resident microbial organisms. The lab works toward this goal through the following project themes: 1. Identify the microbial and host mechanisms required for developmental phenotypes in the pancreas. 2. Determine whether missing out on specific microbial exposures in early life has consequences for adult pancreatic health outcomes. 3. Harness microbe-inspired mechanisms to prevent or reverse pancreatic disease. 
Holers, Michael, MDProfessor and ChairMedicine- RheumatologyComplement 3d receptors, rheumatoid arthritis, experimental arthritis, complement receptors, autoantibodiesA major goal of Dr. Holers’ research program is to understand the shared molecular mechanisms and biomarker patterns that underlie the development of human rheumatoid arthritis (RA), Type 1 Diabetes (T1D) and other autoimmune diseases in order to develop screening and prevention strategies. Dr. Holers’ laboratory is exploring the early mechanisms that underlie the loss of self- tolerance in RA, with the goal of expanding those approaches to T1D and other autoimmune diseases.
Holthrop, Jodi, PhD/MCHESProfessor and Vice Chair for ResearchFamily MedicineDelivery of diabetes care in primary care; obesity management; implementation of health promotion in health care settingsThe major goal of Dr. Holtrop’s research is to improve health care delivery with a focus on integrating health promotion, health behavior change, and preventive care in primary care. Health conditions of particular interest include obesity and type 2 diabetes prevention and management. Dr. Holtrop is a health services researcher and implementation scientist with expertise in qualitative and mixed methods research; she contributes this expertise to working with a wide variety of researchers as they seek to effectively implement evidence-based interventions into practice.
Hsieh, Elena, MDAssistant professorPediatrics - Allergy & ImmunologyT1D cognate interactions between insulin reactive T and B cellsDr. Hsieh’s overall goal is to understand mechanisms of pathogenesis in patients with autoimmunity. In particular, she is interested in identifying and targeting dysregulated signaling pathways and cytokine networks in autoimmunity for therapeutic and/or prognostic clinical applications. Particularly she is interested in systemic lupus erythematous (SLE) and type 1 diabetes (T1D).  In T1D, she is interested in understanding immune interactions between antigen specific T and B cells, macrophages, dendritic cells, and other cells resident in pancreatic lymph nodes and spleen of T1D patients.  She hopes to understand these organ-specific immune interactions in the context of peripheral blood biomarkers, which will ultimately lead to improved diagnostic, prognostic and treatment options.
Huebschmann, Amy, MDAssociate professorMedicine- Internal MedicineExercise, Type 2 diabetes mellitus, Dr. Huebschmann’s early areas of research into physical activity barriers and cardiovascular abnormalities for people with Type 2 Diabetes (T2D) have naturally led to her current focus- increased physical activity for chronically diseased patient populations.  As patient-centered medical homes are emerging as the new standard in patient care, researchers and health systems need to develop innovative methods to bring value to healthcare for patients with chronic diseases.  The overarching goal of this line of inquiry is to optimize evidence-based interventions that have been effective to improve chronic diseases in RCTs, and to adapt those interventions to be feasible for delivery in patient-centered medical homes.  Dr. Huebschmann also seeks to develop methods to deliver these types of interventions in community health settings, and has developed and published pilot work with our local African-American community.
Hunter, Kendall, PhDAssociate professorBioengineeringPulmonary hypertension, cardiovascular modelsDr. Hunter’s (he/his/him) interests lie in cardiac and pulmonary imaging diagnostics, and he currently focuses on examining the development, diagnosis, and progression of cardiac and vascular dysfunction in diabetes. Of particular interest in Dr. Hunter’s work is early data on type 1 diabetes (T1D) in children demonstrating the significantly greater sensitivity of aortic wall shear stress as a measure of flow disturbance. Additionally, several other flow parameters (vorticity, helicity) have shown promise as early detectors of left ventricular dysfunction. Future work is to further develop technology (analysis pipeline and software) and apply it to analysis of MR images from an adult type 2 diabetic population. 
Iyer, Srividhya, PhDAssistant ProfessorOrthopedicsskeletal homeostasis, ER stressResearch in Dr. Iyer’s laboratory is focused on role of  endoplasmic reticulum (ER) health and unfolded protein response (UPR) in maintaining skeletal homeostasis. Using a combination of conditional mice knockouts, skeletal architecture analysis and microscopy based imaging of skeletal tissues in addition to invitro systems we delineate the mechanistic basis of how these processes are dysregulated in pathologic bone loss.
Jacobelli, Jordan, PhDAssociate professorImmunology & MicrobiologyCytoskeleton, immune cell migration, type 1 DiabetesDr. Jacobelli's laboratory is interested in understanding how a network of proteins called the cytoskeleton regulates the migration and cell-cell interactions of lymphocytes. His main research focus is on mouse models of autoimmunity, and type 1 diabetes in particular. His work is aimed at understanding the mechanisms by which specific cytoskeletal molecules promote lymphocyte exit from the blood flow, infiltration into the pancreas, and pathogenesis. His long-term goal is to inhibit the pathogenic potential of autoreactive lymphocytes in type 1 diabetes.
Jansson, Thomas, MD/PhDProfessorOB/GYN Reproductive SciencesGestational diabetes, fetal programming of obesity and diabetesEmerging evidence suggests that changes in placental function determines life-long health, including the risk of developing obesity and T2D later in life,  and Dr. Jansson's research program is focused on determining the mechanistic links underpinning these associations. In addition, his lab is exploring the role placental small extracellular vesicles (‘exosomes”) in modulating maternal glucose homeostasis in normal pregnancy and in mediating the development of gestational diabetes. 
Jia, Xiaofan MD PhDResearch Assistant ProfessorPediatrics- Barbara Davis Centerislet autoantibody, antibody assay, type 1 diabetes, biomarkersDr. Jia's primary research focus is on humoral autoimmunity and serological biomarkers of type 1 diabetes. Her research work include: 1) Development and validation of multiplexed electrochemiluminescence (ECL) autoantibody assay serving for screening type 1 diabetes and other autoimmune diseases in general population, explore combining genetic risk scores with ECL autoantibody to enhance type 1 diabetes prediction; 2) Investigate new autoantibodies against neo-antigens from post-translational modification on islet antigens, and novel β-cell surface autoantibodies to extracellular epitopes of ZnT8 and IA-2, aiming to enhance early and accurate prediction of type 1 diabetes. 
Kelsey, Megan, MDAssociate professorPediatrics - EndocrinologyInsulin resistance, Type 2 diabetes mellitus, glycated hemoglobin A, pediatric obesityDr. Kelsey’s long-term goal is to make a significant contribution to improvement of targeted strategies to prevent youth-onset type 2 diabetes. She has a broad background in obesity and obesity related disorders, focusing specifically on insulin resistance and related metabolic disorders during her pediatric endocrinology fellowship. Her current research involves investigation of metabolic and hormonal changes during puberty on the development of cardiometabolic diseases, particularly in obese youth. 
Knight, Jefferson, PhDAssociate professorChemistryLiposomes, insulin, insulin-secreting cells, diabetes mellitus, type 2Dr. Knight’s research investigates molecular mechanisms of protein-lipid interaction, with a major focus on proteins that are central to the pathway of insulin secretion. His lab uses spectroscopic, biochemical, and single-molecule approaches to determine lipid preferences, membrane affinities, kinetics, and structures of membrane-bound proteins. He is particularly interested in how these secretory proteins are impacted by changes in membrane composition and protein structure that accompany long-term changes in type 2 diabetes and beta cell deterioration.  
Lanaspa, Miguel A.  DVMAssociate ProfessorMedicine/Endocrinology, Metabolism and DiabetesFructose Uric Acid Metabolism Obesity Energy BalanceDr Lanaspa has been funded by the NIH for the last 12 years and his goal has always been to find a cure for metabolic syndrome, obesity and diabetes with more than 90 % of his >160 peer-reviewed publications and patents related to this topic. Specifically, for the last 15 years his lab has focused on the understanding of how the metabolism of sugar, and particularly fructose, promotes metabolic dysregulation, fat accumulation and insulin resistance. His lab helped discover two promising targets for the treatment of sugar-induced metabolic syndrome, fructokinase, the first enzyme in fructose metabolism,  and the purine degradation pathway, an enzymatic route which in humans produces uric acid which controls energy balance and metabolic regulation. The characterization of of how sugar is metabolized to cause metabolic syndrome has recently led him to identify  a new promising target to simultaneously treat both diabetes and obesity by metabolically regulating the activities of the pentose phosphate and the phosphoribosyl phosphate pathways. The characterization of these pathways in diabetes is currently the main focus of his research.
MacLean, Paul, PhDProfessorMedicine- Endocrinology, Metabolism and DiabetesObesity, weight gain, weight loss, energy metabolism, dietary fatsDr. MacLean’s research has focused on the metabolic complications of obesity, diabetes, and the therapeutic strategies that facilitate long term weight loss maintenance.  In recent years, Dr. MacLean’s efforts have centered on how obesity and diabetes affect critical aspects of women’s health throughout the lifespan, including the development and function of the mammary gland, perinatal programming, the menopausal transition, and risk for breast cancer. His research program takes an integrative perspective on the wealth of knowledge generated from mechanistic basic science studies of energy balance and serves as a translational bridge for this information to improve our understanding of human physiology.
Magin, Chelsea  PhDAssistant ProfessorBioengineering3D models, lung, pulmonary, hydrogels, biomaterialsDr. Magin is an Assistant Professor in the Departments of Bioengineering, Pediatrics and Medicine, Division of Pulmonary Sciences and Critical Care Medicine at the University of Colorado, Denver | Anschutz Medical Campus. Her scientific interests focus on using innovative biomaterials, including dynamically stiffening systems and bioengineering approaches, such as 3D printing, to build in vitro models of chronic pulmonary diseases that can be combined with human cells to replicate key aspects of pathobiology not otherwise reproducible in animal models or with traditional cell-culture techniques. To create new tools that enable us to study the influence of cell-matrix, cell-cell, and inhalational exposures on cellular responses in vitro, the Magin laboratory has developed novel methods to synthesize and microfabricate hydrogel biomaterials that are degradable instantaneously by exposure to light or slowly over time in response to enzymes released by cells and is uniquely positioned to conduct high-throughput 3D studies using human cells, which are not currently possible in traditional models of lung injury. Our goal is to better recapitulate the processes of injury and disease progression in vivo and contribute innovative approaches to prevention and intervention.  Over the past six years her research has been funded by 15 grants including an R01 and R21 from the National Institutes of Health, a CAREER Award from the National Science Foundation, and a Discovery Award from Department of Defense. These awards have allowed her to run a supportive and inclusive research group that has trained 5 PhD students, 6 MS students, 15 undergraduates, 3 Postdocs, 1 Medical Fellow, and 3 Professional Research Assistants that have gone on to variety of research careers in academia and industry. In this time, she has published 20 peer-reviewed papers (total publications=34, h-index=19, citations >2,300) and applied for 2 patents. Chronic pulmonary and vascular diseases are exacerbated by diabetes.  
Masters, Kristyn  PhDProfessor and ChairBioengineeringtissue engineering, wound healingThe Masters lab employs techniques from biomaterials, tissue engineering, bioconjugate chemistry, gene editing, and microfabrication, to create in vitro environments that model disease progression. Through this approach, the Masters Lab seeks to decipher disease pathogenesis, with the intent of using this knowledge to inform the design of clinical therapies. In the context of diabetes-related research, PI Masters has applied this approach to study chronic wound healing, with the goal of identifying molecular targets responsible for accelerating healing in diseased environments (e.g., diabetic wounds). 
Matsuda, Jennifer, PhDDirector, Genetically Engineered Murine Models (GEMM), and visiting professorDepartment of Immunology and Microbiologycreation and sharing of genetically modified miceDr. Matsuda is the director of the Genetically Engineered Murine Models (GEMM) Core, which provides full-service mouse genetic engineering support to researchers.  We will help you select the best model for your research program, design and build any requisite constructs and reagents, and produce live mice.  The most popular requests are for CRISPR-based gene edited mice and transgenic mice.  To date, we have created engineered alleles for knockouts, conditional knockouts, SNP knockins, tag and marker insertions, deletions of up to 300kb, duplications, and transgenic alleles. These novel mouse models have been made on a wide spectrum of genetic background strains, including but not limited to C57BL/6J, C57BL/6N, NOD, BALB/cJ, FVB/Crl, NSGS, various 129 substrains, collaborative cross strains, and on mice that are already genetically modified. Our robust breeding and genotyping program supports breeding to establish germline transmission and can also create cohorts for investigators.  We also provide strain cryopreservation, rederivation and rescue services, as well as cryostorage.  We also support outside institutions, nationally and internationally.    
McKinsey, Timothy  PhDProfessorMedicineCardiometabolic disease, epigenetics, signalingDr. McKinsey's lab is focuses on elucidating molecular mechanisms that contribute to the pathogenesis of obesity and heart failure. The group using in vitro, cellular and in vivo models to uncover roles of epigenetic and signaling modulators in the control of cardiometabolic disease. 
Melanson, Ed, PhDProfessorMedicine- Endocrinology, Metabolism and DiabetesEnergy metabolism, exercise, calorimetry, dietary fats, oxygen consumptionEdward Melanson PhD, is a Professor of Medicine, Division of Endocrinology, Metabolism and Diabetes, with a secondary appointment in the Division of Geriatrics.  Dr. Melanson’s interests are on the effects of diet, exercise, and obesity on substrate metabolism and energy expenditure. 
Mestroni, Luisa MDProfessorMedicine/Cardiologygenetics, heart failure, cardiomyopathiesDr. Mestroni's research is focused on molecular genetics of heart muscle diseases, from clinical to translational studies, aiming at the discovery of mechanisms and potentially new therapies.
Michels, Aaron, MDAssociate professorPediatrics- Barbara Davis Center Diabetes mellitus Type 1, insulin, autoantigens, antigen T-cell receptors, programmed cell death 1 receptorDr. Michels’ laboratory investigates the immunology of autoimmune diseases, with a particular focus on type 1 diabetes. Over the last several years, the Michels group has investigated the structural immunology of autoantigen presentation to T cell receptors, and used this structural immunology knowledge to develop a novel research area with small molecules targeted to MHC class II antigen presentation. Another area of interest for Dr. Michels is to understand the role of MHC class II alleles in predisposing and providing dominant protection from type 1 diabetes development. 
Miyazaki, Makoto, PhDProfessorMed/Renallipid metabolism, cardiovascular diseases, kidney, obesity, diabetesMiyazaki Lab strives to identify novel therapeutic targets for treatment of CKD and diabetes complications. In pursuit of this goal, we have investigated molecules and mechanisms that trigger ectopic mineralization and vascular toxicities in CKD and diabetes. In the past, we have discovered that several metabolites (i.e., saturated fatty acids and bile acids) and kidney-specific proteins (i.e., TMEMs) as well as intracellular signaling (i.e., autophagy, ER stress and cell death) contribute to CKD and diabetes complications.
Nadeau, Kristen, MDProfessorPediatrics - EndocrinologyInsulin resistance, Type 1 and Type 2 diabetes mellitus, obesity, glycated hemoglobin A Dr. Nadeau is a pediatric endocrinologist focused on reducing the long-term complications of youth-onset type 1 (T1D) and type 2 diabetes (T2D), with an emphasis on similarities/differences between the mechanisms of insulin resistance (IR) in T1D vs. T2D, as well as early cardiopulmonary, hepatic, muscle, renal and β-cell dysfunction in youth with diabetes. Her current focus is on local and multi-center interventions to reduce complications of obesity and diabetes by addressing exercise and cardiovascular dysfunction, insulin resistance, and β-cell failure in youth and adults. She also collaborates with nephrologists on understanding mechanisms underlying diabetic kidney disease. 
Nagaraj, Ram PhDProfessor OpphthalmologyDiabetic retinopathy, animal models 
Nakayama, Maki, MD/PhDAssociate professorPediatrics- Barbara Davis Center Insulin, autoantigens, Type 1 diabetes mellitus, peptide fragments, CD4-positive T-lymphocytesThe primary focus of Dr. Nakayama’s laboratory is to elucidate the mechanism by which anti-islet autoimmunity causing type 1 diabetes (T1D) is initiated, from the point of view of the tri-molecular complex consisting of antigen, major histocompatibility complex (MHC), and T cell receptor (TCR) that could be a key component for the development of T1D.  Current projects include (1) identifying TCR sequences of T cells infiltrating pancreatic islets of T1D organ donors, (2) identifying antigen specificity of islet T cells, and (3) pursuing the potential of TCR sequences to be used as T cell biomarker to predict the T1D development. 
Nicklas, Jacinda, MD/MPHAssistant professorMedicine- Internal MedicineGestational diabetes, postpartum period, life style, Type 2 diabetes mellitusThe main focus of Dr. Nicklas’ research is the prevention of diabetes, cardiovascular disease, and obesity, with a particular focus on postpartum women. Her early research focused on acclimatization to high altitude in women over the menstrual cycle and several studies looked at obesity in men and women, including a study in NHANES looking at weight loss among obese Americans and a study looking at the impact of weight loss on levels of C-reactive protein. Dr. Nicklas has also developed an innovative mobile health program called Fit After Baby, designed for postpartum women at elevated risk for diabetes and heart disease.
Norris, Jill, PhDProfessor and ChairEpidemiologyAutoimmunity, diabetes mellitus, type 1, autoantibodies, islets of Langerhans, arthritis, rheumatoidDr. Norris’ research has focused on the relationship between environment and the development of autoimmune diseases, including type 1 diabetes (T1D), celiac disease, rheumatoid arthritis, and lupus in genetically susceptible individuals.  Her work is focused on the role of maternal, infant, childhood and adult dietary factors and the etiology of T1D, using metabolomics, epigenomics and microbiome studies in large, at-risk populations. It is hoped that these studies may shed light on the long-standing issue of the relationship between genes and environment in the development of autoimmune diseases. 
O'Donnell, Holly, PhDAssistant ProfessorPediatrics, Barbara Davis Centerpsychology, behavior, pediatrics, type 1 diabetes, anxietyDr. O'Donnell's research interests include 1) psychological impact of screening for type 1 diabetes (genetic risk and autoantibodies); 2) psychological aspects of living with type 1 diabetes (e.g., fear of hypoglycemia, diabetes distress, burnout); and 3) screening for psychological barriers to adherence and integration into clinical care. She is a member of the Psychosocial Committees for TEDDY and TrialNet, and serves as the consulting psychologist for ASK and ASK the Experts at the Barbara Davis Center. She currently is the PI of a pilot grant examining the psychological experience of children in ASK (e.g., anxiety about developing T1D) as well as predictors of engagement and retention in the monitoring program. She also recently received a grant from JDRF to develop an anxiety intervention for individuals identified as at high risk for type 1 diabetes by islet autoantibody screening. Clinically, she enjoys working with patients of all ages and their families to address psychological aspects of living with type 1 diabetes and improve quality of life. Dr. O'Donnell trained as a pediatric psychologist and completed a two-year postdoctoral fellowship in pediatric type 1 diabetes.  
Oser, Tamara, MDAssociate Professor and Director of the High Plains Research NetworkFamily Medicinetype 1 diabetes mellitus, type 2 diabetes mellitus, peer support, continuous glucose monitoring, closed-loop system, primary care, lifestyle interventions, self-management, rural, educationDr. Oser’s research is focused on how to best incorporate diabetes technologies into primary care, the use of peer support to supplement diabetes care, and developing and testing new interventions to help people with diabetes in their self-management that can be implemented into primary care. In her role as Director of the High Plains Research Network, she is committed to reducing disparities in diabetes care and developing culturally relevant resources and care for people with diabetes living in rural settings.
Pelanda, Roberta, PhDProfessorImmunology & MicrobiologyMolecular mechanisms of immune tolerance, immunology, rheumatology, pediatric gastroenterologyA major goal of Dr. Pelanda’s research program is to understand how B cells contribute to autoimmune responses, including type 1 diabetes (T1D). Her laboratory is exploring how and why central B cell tolerance is subverted in some autoimmune individuals, and the contribution of bone marrow-generated autoreactive B cells to autoimmunity. The Pelanda lab is working to identify the signals that cause the entry of bone marrow autoreactive B cells into the circulation and the role these cells play in T1D and other diseases using a novel humanized mouse model, developed by Dr. Pelanda and colleagues.
Polsky, Sarit, MDAssistant professorPediatrics- Barbara Davis Center Pregnancy in diabetes, insulin infusion systems, blood glucose, Type 1 diabetes mellitus, blood glucose self-monitoringDr. Polsky’s research focuses on 3 main targets areas: 1) advanced diabetes technologies and therapeutics to investigate newly developed insulins, continuous glucose monitoring systems, insulin pumps, and artificial pancreas technologies; 2) therapies to improve diabetes complications; 3) research focusing on women’s health and diabetes. She particularly examines how advanced diabetes technologies affect glycemic indices and gestational outcomes in pregnant women with T1DM.
Pyle, Laura, PhDAssociate professorPediatrics, Biostatistics and InformaticsBiostatistics, Diabetes mellitus Type 1 and 2, insulin resistance, blood glucose, diabetic nephropathiesThe overall focus of Dr. Pyle’s research is the application of novel statistical methodology to questions related to diabetes (type 1 and 2), obesity, and related conditions and comorbidities, particularly in children and adolescents.  She has extensive experience in the design, operation, and analysis of longitudinal clinical trials and epidemiologic studies. She has developed new statistical methods for analysis of data from hyperinsulinemic euglycemic clamps with isotope tracers, used to measure insulin resistance in particular tissues.  
Raghavan, Sridharan, MD/PhDAssistant professorMedicine-Hospital Medicine, Biomedical Informatics and Personalized Medicine, Rocky Mountain VA Medical CenterBioinformatics, personalized medicine, genetic data repositories, cardiovascular diseaseDr. Raghavan is a hospitalist whose research focuses on precision medicine applied to the prevention and treatment of obesity, diabetes, and their complications, particularly cardiovascular disease. He is interested in leveraging electronic health record data and genetic data to identify novel risk factors for cardiometabolic diseases, and to build risk models optimized to the real-world patient population of a health system to guide individualized targeting of preventive and treatment interventions for obesity, diabetes, and diabetes complications.
Rasouli, Neda, MDAssociate professorMedicine- Endocrinology, Metabolism and DiabetesInsulin resistance, adipose tissue, hypoglycemic agents, obesity, diabetes mellitus Type 1 and 2Dr Rasouli is the director of the Diabetes and Endocrinology clinical trial program. Her focus is on investigation of optimal treatment of patients with diabetes and metabolic disorders associated with obesity. Her research interests also include study of the pathophysiology of insulin resistance, particularly molecular mechanisms involved in adipose tissue inflammation and lipotoxicty associated with obesity and insulin resistance.
Regensteiner, Judith, PhDProfessorMedicine- Internal MedicineDiabetes mellitus Type 2, exercise, exercise therapy, peripheral vascular diseasesThe Regensteiner lab is focused on characterizing and targeting the mechanisms that lead to decreased maximal exercise capacity and slowed exercise kinetics in diabetic patients. Their group has found that this defect is present not only in adults and adolescents with T2D, but also in those with type 1 diabetes (T1D), particularly women. Their studies point to a role for decreased tissue oxygen delivery in the exercise impairment of T2D, offering a potentially target for therapeutic treatment to improve exercise function.
Reusch, Jane, MDProfessorMedicine- Endocrinology, Metabolism and DiabetesDiabetes mellitus Type 2, mitochondria muscle, cyclic AMP response element-binding proteinThe overarching theme of Dr. Reusch’s basic and clinical-translational research is that chronic metabolic, oxidative, and inflammatory stresses associated with diabetes decrease homeostasis, which in turn, contributes to diabetic complications. The long-term goal of the Reusch group is to develop a combination of behavioral and pharmacological therapies to normalize cardiovascular function and fitness for people with diabetes.
Rewers, Marian, MD/PhDProfessorExecutive Director- Barbara Davis Center Diabetes mellitus Type 1, autoimmunity, autoantibodies, islets of Langerhans, celiac diseaseThe epidemiology and etiology of type 1 diabetes is Dr. Rewers’ primary area of research, with the goal to identify environmental causes of autoimmune diabetes and to translate these findings to prevention. Additional active areas of research include celiac disease and complications of diabetes. He directs a large NIH-funded cohort Diabetes Autoimmunity Study in the Young (DAISY) and co-chairs the multicenter consortium The Environmental Determinants of Diabetes in the Young (TEDDY). He is directing a general population screening for pre-symptomatic type 1 diabetes and celiac disease (ASK) funded by the JDRF and Helmsley Trust to facilitate prevention and most effective early treatment for these disorders.
Roark, Christina, PhDAssistant professorMedicine- Allergy & Clinical ImmunologyT-lymphocyte subsets, HLA-DRB1 chains, receptors, antigen, t-cell, gamma-deltaDr. Roark’s laboratory research is focused on better understanding the molecular mechanisms behind the strong association between HLA and many autoimmune diseases. They have developed a computer program that analyzes millions of shared epitopes comprising one to five non-contiguous amino acids between control and patient groups. This analysis has identified critical amino acid epitopes that are shared between disparate alleles that are strongly associated with either susceptibility or resistance to Type I diabetes. They have performed mutagenesis studies to dissect how these critical residues influence peptide binding and presentation to autoreactive T cells.
Rozance, Paul, MDProfessorPediatrics - Neonatal Medicine Glucose, insulin, fetus, islet IUGR, insulin secretionDr. Rozance’s research is focused on the impact of fetal nutrient and growth restriction on the function and development of the endocrine pancreas and other organs. He focuses on the mechanisms by which the fetus adapts to intrauterine growth restriction by altering insulin secretion and glucose metabolism, and how these adaptations predispose the fetus to adult onset diseases like diabetes, obesity, and metabolic syndrome. Investigations by the Rozance group include studies of glucose tolerance in fetuses in vivo, as well as ex vivo measurement of insulin secretion, biosynthesis and metabolism on isolated sheep islets. 
Sandoval, Darleen, PhDProfessorPediatrics-Nutrition Section,Medicine-Endocrinology, Metabolism and DiabetesGLP-1, bariatric surgery, energy homeostasis, lipid homeostasis, type 2 diabetesDr. Sandoval's current work utilizes basic research strategies to focus on two general themes of research. The first goal is to gain understanding on the role of a gastrointestinal peptide, GLP-1, in the gut-brain axis to regulate energy and glucose homeostasis. The second is to gain understanding on the adaptations of the gut-brain axis with bariatric surgery and how this leads to the profound weight-loss and improvements in glucose and lipid homeostasis seen with these surgeries. Both research themes use a combination of molecular and physiological techniques with the goal of generating better therapeutic options for obesity and type 2 diabetes.
Scalzo, Rebecca, PhDAssistant professorMedicine- Endocrinology, Metabolism and DiabetesGlucose tolerance test, glucose, insulin, insulin resistance, type 2 diabetes, exercise , sex differencesDr. Scalzo is interested in the impact of type 2 diabetes on skeletal muscle mitochondrial content and function and how changes in mitochondria with diabetes affect cardiorespiratory fitness. She is particularly interested in determining how type 2 diabetes affects these outcomes differently in women and men. Currently, Dr. Scalzo is addressing the effect of type 2 diabetes on estrogen-mediated support of skeletal muscle mitochondrial content and function with her VA Career Development Award (VA-CDA2). 
Schauer, Irene, MD/PhDAssociate professorMedicine- Endocrinology, Metabolism and DiabetesExercise, metabolism, insulin management,  insulin clamp technique, insulin resistance, hyperinsulinismThe goal of Dr. Schauer’s research is understand the causes and consequences of insulin resistance, in both type 1 and type 2 diabetes, and to take this knowledge “to the bedside” to achieve improved management of the macrovascular complications of diabetes. She is currently using state-of-the-art high resolution mitochondrial respirometry techniques, as well as vascular studies, hyperinsulinemic euglycemic clamps with tracers, and our new MRS methodology for in vivo mitochondrial function measurements in physiological studies aimed at measurement of the effects of existing diabetes medications on glucose control, insulin sensitivity, and vascular and mitochondrial function in T1D.
Scott-Browne, James PhDAssistant ProfessorImmunology, National Jewishtranscriptional regulation, immunotherapy, autoimmunity, cancer 
Shen, Jingshi, PhDProfessorUCB- Molecular, Cellular & Developmental BiologyInsulin response in adipocytes and musclesA major function of insulin is to promote glucose uptake into muscle and adipose tissues, a process mediated by the glucose transporter GLUT4. Upon insulin stimulation, GLUT4 is relocated from intracellular storage vesicles to the cell surface through regulated exocytosis. Dr. Shen has developed new tools to unravel the protein-protein networks governing insulin-regulated GLUT4 exocytosis. 
Shomaker, Lauren  PhDAssistant Clinical Professor (CU)Pediatric EndocrinologyAdolescent Depression Anxiety Clinical Trials Insulin ResistanceI am a tenured Associate Professor in the College of Health and Human Sciences at Colorado State University with over 15 years of experience studying the mental health and physical health of adolescents. I have specific interests in (i) understanding the effects of social stressors (e.g., adverse life experiences) and psychological distress (e.g., depression) on adverse cardiometabolic health consequences, and (ii) developing integrative, prevention and treatment efforts to ameliorate the mental and the physical health of youth with disproportionate health risks. My research program includes randomized controlled efficacy and effectiveness behavioral trials, experimental laboratory studies, longitudinal follow-up of teenagers as they develop into young adults, and comprehensive phenotyping, including behavioral, cognitive, psychological, physical, and metabolic assessments. I also use community-based participatory research methods to develop and test feasible and effective community-based interventions. I am well versed in collaborating and leading interdisciplinary teams, including working with stakeholders in academic, healthcare, and community settings. Throughout my career, I have been committed to mentoring, including mentoring of undergraduate students, graduate students, postbaccalaureate associates, and postdocs. Since transitioning to mid-career faculty, I have provided research mentorship to early-stage faculty investigators at Colorado State University as well as throughout the Colorado Clinical and Translational Sciences Institute.
Simmons, Kimber, MDAssistant professorPediatrics - EndocrinologyDiabetes mellitus Type 1, autoantiboides, insulin-secreting cells, insulin antibodies, dried blood spot testingDr. Simmons’s primary focus is to understand mechanisms of T1D disease heterogeneity by studying diverse populations for immunologic, genetic and metabolic factors that allow for T1D development. Dr. Simmons developed methodology to measure all four islet autoantibodies (Ab), notably insulin autoantibody, from a dried blood spot (DBS) on filter paper. Dr. Simmons uses the DBS methodology to screen children in the general population for T1D and to better characterize diabetes in under-resourced countries in collaboration with Life for a Child ( to determine the prevalence of Ab positivity in new and recent-onset cases of childhood and youth diabetes.
Simon, Stacey, PhDAssociate professorPediatrics - Pulmonary MedicineInsulin resistance, chronic disease, sleep, circadian rhythmsDr. Simon’s research is focused on mechanisms underlying the negative cardiometabolic consequences of insufficient sleep and circadian misalignment in adolescents, particularly those with type 1 and type 2 diabetes. This research is laying the foundation for the development of sleep and circadian health intervention with a goal of improving health outcomes including insulin resistance and glycemic control in youth with type 1 and type 2 diabetes. 
Sirlanci, Melike  PhDAssistant ProfessorDivision of Informatics and Data Sciencetype 2 diabetes, physiology-based mechanistic models, machine learningThe overarching goal of Dr. Sirlanci's research is to investigate problems arising in biomedicine using mathematics-based
methodologies, which consists of data assimilation (DA) techniques, which are used for inference, forecasting,
and control of the systems whose dynamics could be described by physiology-based mechanistic models, and
machine learning (ML) methods, which are used for similar purposes within more data-rich environments
especially when a mechanistic model of the system of interest is not available
Smith, Mia, PhD/DVMInstructorPediatrics- Barbara Davis Center B-lymphocytes, prediabetic state, autoimmunity, autoantibodies, clonal anergyThe main focus of Dr. Smith’s research is in understanding how self-reactive B cells contribute to development of autoimmunity, particularly in human type 1 diabetes patients. Current studies are aimed at exploring whether B cells from FDRs who carry the diabetes associated PTPN2 SNP show changes in activation and are hyperresponsive to stimulation immediately ex vivo. In addition, her research is also focused on comparing the phenotype and function of B cells during development of early onset T1D and late onset T1D using mass cytometry (CyTOF). 
Snell-Bergeon, Janet, PhDAssociate professorPediatrics- Barbara Davis Center Diabetes mellitus Type 1, coronary artery disease, diabetic angiopthies, diabetic nephropathy, vascular calcificationDr. Snell-Bergeon’s primary area of interest is in the prevention of cardiovascular and renal complications of type 1 diabetes, and identifying the mechanisms for sex differences in these complications. She has considerable experience conducting epidemiologic studies of vascular health and complications in type 1 diabetes. 
Sokol, Ronald, MDProfessor and Vice ChairPediatrics, Biomedical Informaticsparenteral nutrition associated liver disease, gut-liver axis, clinical and translational researchDr. Sokol's current laboratory-based research investigates the pathogenesis of parenteral nutrition associated cholestasis and steatosis liver disease (also called intestinal failure associated liver disease; IFALD).  His lab has developed a novel mouse model that combines intestinal injury with total parenteral nutrition that mimics the pathophysiology in humans and has shown that the gut-liver axis is a key component as well as toxicity from plant sterols that are contained in the parenterally administered plant-based lipid emulsions. He is are also very interested in understanding the role of GLP-1 agonists in the possible resolution of this liver disease. He is also involved in a number of clinical research projects investigating obesity associated NAFLD in adolescents and the role of exosomes in mediating cellular cross-talk that initiates the liver injury and fibrosis.
Steck, Andrea, MDAssociate professorPediatrics- Barbara Davis Center Type 1 diabetes prediction, islet autoantibodies, ECL assays, genetic risk for T1D, islet autoimmunityDr. Steck’s primary research focus is in the area of epidemiology, immunogenetics, prediction and prevention of type 1 diabetes. Her research interest and expertise include work with large longitudinal prospective studies such as DAISY (Diabetes Autoimmunity Study in the Young), TEDDY (The Environmental Determinants of Diabetes in the Young), TrialNet and the Twin Family Study. She is the Colorado PI for several multisite clinical research trials in type 1 diabetes prevention and intervention through both Industry and NIH TrialNet.  
Sussel, Lori, PhDProfessor and Research DirectorPediatrics- Barbara Davis Center Islets of Langerhans, insulin-secreting cells, pancreas, transcription factors, homeodomain proteinsThe main focus of Dr. Sussel’s research is to understand the complex transcriptional networks that regulate development, differentiation and function of the pancreatic islet.  Currently, her research addresses issues relating to the regulation of beta cell identity and function with a specific focus on how disruption of transcription factors and long non-coding RNA activity contribute to type 1 and type 2 diabetes. 
Theiss, Arianne  PhDAssociate ProfessorMedicineobesity, metabolism, intestinal epithelium, mitochondriaArianne Theiss, PhD is an Associate Professor of Medicine in the Division of Gastroenterology and Hepatology at UCD. Her basic and translational research program is focused on the role of epithelial cell mitochondrial stress in the pathogenesis of inflammatory bowel diseases and neoplastic progression. She is interested in elucidating the role of adipose tissue secreted factors in driving colorectal cancer initiation and progression during obesity. 
Tommerdahl, Kalie, MDInstructorPediatrics-EndocrinologyType 1 and Type 2 Diabetes, insulin resistance, diabetic kidney disease, cardiovascular disease, diabetes technologies, pharmacologic therapiesDr. Tommerdahl’s research focuses on reducing kidney and cardiovascular complications in youth-onset diabetes, with an emphasis on modifying existing insulin resistance, endothelial and vascular dysfunction, renal vascular resistance, and supraphysiologic insulin exposure. Dr. Tommerdahl’s overall goal is to identify novel, synergistic therapeutic treatment regimens including diabetes technologies and pharmacologic therapies to impede the development of diabetic kidney disease and cardiovascular disease in youth with type 1 diabetes and eventually apply this knowledge to individuals of all ages and types of diabetes.
Torres, Raul  PhDProfessor of Immunology & MicrobiologyDepartment of Immunology & MicrobiologyB-lymphocytes, autoantigens, peripheral immune tolerance, signal transduction receptorsA major effort of the Torres laboratory centers on understanding how peripheral immune tolerance is regulated to restrain autoreactive B lymphocytes under homeostatic and inflammatory settings. Using human peripheral blood and genetically engineered mouse models we have demonstrated that weakly autoreactive lymphocytes can be released from restraint under certain inflammatory settings indicating that peripheral immune tolerance is dynamically regulated.
Triolo, Taylor, MDAssistant professorPediatrics - Endocrinology & Barbara Davis CenterAutoimmune diseases, diabetes mellitus Type 1, autoantibodiesThe main focus of Dr. Triolo’s research is to merge clinical investigation with basic science research strategies in the field of type 1 diabetes.  Her clinical research has focused on understanding the development of autoantibodies and progression to type 1 diabetes and preventing progression to type 1 diabetes.  Her basic science research is focused on the role of high risk type 1 diabetes genes in human beta cell function.  
Vagnozzi, Ronald  PhDAssistant ProfessorMedicine/Cardiologyinflammation, macrophages, cardio-immunology, fibrosis, cell signalingDr. Vagnozzi is a basic cardiovascular scientist and Assistant Professor in the Division of Cardiology. His areas of research expertise include signal transduction mechanisms in myocardial infarction and cardiac remodeling, genetic linage tracing and rodent models of cardiac disease, and macrophage-fibroblast crosstalk in left ventricular dysfunction. The Vagnozzi lab focuses on the cellular and molecular mechanisms of chronic inflammation in cardiovascular diseases. Chronic inflammation and scarring, termed fibrosis, underlie countless disease states and contribute to roughly half of all deaths in the developed world. Therapies to specifically treat pathological inflammation and fibrosis of the heart are lacking. We aim to understand how tissue-resident macrophages (TRMs), a major cellular component of the inflammatory response, can be directed to improve repair and limit fibrosis of the damaged heart. Our research interests include ischemic heart diseases such as myocardial infarction as well as hypertensive heart disease, autoimmune cardiomyopathies, and diabetic cardiomyopathy. In each of these diseases, the immune-fibrosis axis is dysregulated, resulting in chronic inflammation and pathological tissue scarring that compromise tissue and organ function. To uncover mechanistic insights on this disease process, the Vagnozzi lab has recently developed an array of experimental techniques using dual-photon confocal microscopy (via the ALMC), atomic force microscopy, and explanted tissue mechanics to assess ECM structural, functional, and biomechanical alterations following myocardial infarction injury in mice. The lab also has developed dual-reporter lineage tracing models for simultaneous assessment of cardiac macrophage content and fibroblast activation in vivo. The lab's long-term vision is to establish new therapeutic strategies to modulate inflammation and improve patient outcomes across cardiac disease etiology, thus reducing the overall morbidity and mortality of heart failure.
Wadwa, Paul, MDProfessorPediatrics- Barbara Davis Center Diabetes mellitus Type 1, cardiovascular diseases, insulin infusion systems, blood glucose, blood glucose self-monitoringDr. Wadwa serves as the Medical Director of the Pediatric division and Director of Telemedicine at the Barbara Davis Center. His primary research focus is on the development of the artificial pancreas. He serves as the site PI or co-investigator for three UC4 funded artificial pancreas studies, several industry sponsored clinical trials, and several NIH-sponsored and industry- sponsored clinical research studies to advance artificial pancreas technology. Dr. Wadwa is also engaged in clinical trials of new therapeutic agents and the effects of a telemedicine program on glycemic control in type 1 diabetes. 
Wells, Kristen PhDResearch Assistant ProfessorPediatrics - Barbara Davis CenterBioinformatics, cell communication, gene regulation, T1D and T2DDr. Kristen Wells' research focuses on using bioinformatics to analyzing cutting-edge sequencing data generated from both islet endocrine cells and immune cells.  She uses these datasets to answer questions relating transcriptional networks regulating development and function of beta cells, interaction between immune cells in the islet, and learning the role of self-reactive B cells in the development of diabetes. She is primarily interested in building analysis pipelines for analyzing the data generated from novel sequencing techniques and developing robust pipelines that efficiently analyze data in a reproducible way.
Wesolowski, Stephanie, PhDAssociate professorPediatrics - NeonatologyDevelopmental programming, hepatic glucose production, NAFLD, insulin sensitivityDr. Wesolowski’s lab studies how altered nutrient supply programs fetal metabolism, and how these changes may persist after birth and increase susceptibility to adult metabolic disease, including type II diabetes.  Her research investigates mechanisms of early activation of fetal hepatic glucose production and development of hepatic insulin resistance, and the role of reduced glucose versus oxygen supply to the fetus, both key features of placental insufficiency and resulting IUGR. Dr. Wesolowski also studies the effects of maternal high fat diet and obesity on offspring metabolism and non-alcoholic fatty liver disease (NAFLD).  
White, Alicia, MDInstructorPediatrics - NeonatologyNeonatal-perinatal, IGF-1, Beta Cells, GSIS, Maternal diabetes, neonatal diabetesDr. White studies the fetal pancreas and its hormonal influence on growth and metabolism. Recognizing the complex interactions between fetal insulin and IGF-1, and the fact that both hormones are low in growth-restricted fetuses. She examines whether exogenous IGF-1 infusion promotes growth and improves pancreas structure and function in growth-restricted fetal sheep. Furthermore, she has started exploring novel mechanisms that could help explain the acute and long-term pancreatic defects observed in growth-restricted fetuses. In a new collaboration and mentorship with Dr. Clyde Wright, an expert in NFκB signaling, and under the continued mentorship of Dr. Rozance, she is nvestigating the association between NFkB activation in the fetal pancreas and decreased insulin secretion. This is an area of fetal pancreas development that has been understudied, and recent evidence suggests that abnormal fetal β-cell-specific NFκB activation could link intrauterine β-cell failure, lower β-cell mass, and the later development of type 2 diabetes.
Wortham, Matthew PhDAssistant ProfessorPediatrics - Barbara Davis CenterBeta cells, epigenomics, metabolism, insulin secretion, heterogeneityDr. Wortham's laboratory studies how pancreatic beta cells sense and respond to changes in their environment in physiological conditions or pathological states related to diabetes. His research is focused on how environmental signals and cellular metabolism interface with transcriptional regulation in the beta cell to govern adaptive and maladaptive responses. To conduct these studies he employs metabolomics, single cell genomics, genetically engineered mice, and islet functional studies to analyze primary human tissue and animal models of diabetes.
Woulfe, Kathleen, PhDAssistant ProfessorMedicineage and sex differences, cardiac function, sarcomereDr. Woulfe's research program focuses on identifying mechanisms underlying diastolic dysfunction in male and female hearts. Since impaired cardiac relaxation is associated with many different etiologies, determining if there are common changes in the sarcomere that lead to that dysfunction is essential. Of particular interest are age and sex differences in cardiac function physiologically and pathophysiologically. 
Wright, Clyde, MDAssociate professorPediatrics- Neonatology innate immune signaling, NFkB, inflammation, intrauterine growth restrictionDr Wright is a neonatologist who studies the impact of prematurity on long-term health as babies born prematurely face a high burden of systemic morbidities. It is well known that common exposures encountered in the neonatal intensive care unit stimulate innate immune signaling, causing inflammation, injury and abnormal development. Dr. Wright is interested in determining the mechanisms by which clinically relevant exposures stimulate innate immune signaling in order to develop targeted therapeutics to attenuate inflammatory injury and preserve normal development.
Yu, Liping, MDResearch Associate ProfessorPediatrics- Barbara Davis CenterAutoantibodies, diabetes mellitus type 1, islets of Langerhans, antigens, autoimmunity, biomarkers, blood glucoseDr. Yu's research is directed at understanding the immunogenetics and immunopathogenesis of type 1 diabetes, including the mechanistic study of immunotherapy and the development of novel biomarkers and autoantibody assays. His clinical immunology laboratory is currently the NIH/NIDDK designated North America Autoantibody/HLA Core laboratory for type 1 diabetes clinical trials. At this BDC laboratory, immunogenetic and state of the art autoantibody analysis are integrated into clinical care and clinical research with a large population of T1D patients also tested for thyroid, Addison’s, celiac disease, APS-1, and rheumatoid arthritis risk. 
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