University of Colorado Anschutz Medical Campus

Xj Wang MD, PhD

Adjunct Professor and John Gates Endowed Chair of Cancer Stem Cell Biology - Director of the Head, Neck, Cancer Research Program

Pathology (SOM)

Email Address:xj.wang@cuanschutz.edu

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Mailing Address:

CU Anschutz

Research I North

12800 East 19th Avenue

Aurora, CO 80045

Bio
Research, Publications, Projects

Education, Licensure & Certifications

Education:

MD; Beijing Medical University, Beijing, China (1984)
PhD, Neuroscience; Beijing Medical University, Beijing, China (1989)

Postdoctoral Education:

MD Ander Cancer Center (1990-1991)

Training Faculty for Graduate School Programs:

Mentor for MSTP (MD/PhD) students, PhD students and Clinical Fellows
Graduate faculty in MSTP, BSP, Cancer Biology, MolBio, Pharmacology, Immunology
Course lectures in Cancer Biology, Pharmacology, Craniofacial Biology

Research

Research Activities:

Molecular mechanisms of cancer: 1) Mechanisms of immune evasion of cancer and cancer immunotherapy; 2) Role of tumor microenvironment in cancer progression and metastasis; 3) the properties of cancer stem cells; 4) Experimental therapeutics and therapeutic interventions in cancer
Therapeutic interventions in chronic wounds, radiation toxicities, inflammatory skin diseases and fibrosis
Normal stem cell fate determination during embryonic skin development.

Publications and Presentations

Selected publications:

Hernandez AL*, Young, C.D., Bian, L., Weigel, K. Nolan, K., Frederick, B., He, G., Jones, K.L., Rudolph, M.C., Trahan, G.D., Oweida, A.J., Karam, S.D., Raben, D., Wang, X.J (2020). PARP inhibition enhances radiotherapy of SMAD4 deficient human head and neck squamous cell carcinomas in experimental models. Clinical Cancer Research. 2020. Epub 03/05/2020. doi: 10.1158/1078-0432.CCR-19-0514, PubMed PMID: 32139402.
Strait AA*, Wang XJ (2020). The role of transforming growth factor-beta in immune suppression and chronic inflammation of squamous cell carcinomas. Mol Carcinog. 2020 Apr 17. doi: 10.1002/mc.23196. [Epub ahead of print], PMID: 32301180
Luo J*, Bian L, Blevins MA, Wang D, Liang C, Du D, Wu F, Holwerda B, Zhao R, Raben D, Zhou H, Young C, Wang XJ (2019). Smad7 Promotes Healing of Radiotherapy-Induced Oral Mucositis without Compromising Oral Cancer Therapy in a Xenograft Mouse Model. Clin Cancer Res. 25(2): 808-818 PMID:30185419
Li F, Bian L, Iriyama S, Jian Z, Fan B, Luo JJ, Wang DD, Young C, Han GW, Wang XJ (2019). Smad7 ameliorates TGFbeta-mediated skin inflammation and associated wound healing defects but not the susceptibility to experimental skin carcinogenesis. J Invest Dermatol. 139(4):940-950 PubMed PMID: 30423327.
Dionne LK, Peterman E*, Schiel J, Gibieža P, Skeberdis VA, Jimeno A, Wang XJ**, Prekeris R. FYCO1 regulates accumulation of post-mitotic midbodies by mediating LC3-dependent midbody degradation..J Cell Sci. 2017 Dec 1;130(23):4051-4062. doi: 10.1242/jcs.208983. PMID: 29196475. ** Co-corresponding author
Haeger SM, Thompson JJ, Kalra S, Cleaver TG, Merrick D, Wang XJ, Malkoski SP (2016). Smad4 loss promotes lung cancer formation but increases sensitivity to DNA topoisomerase inhibitors. Oncogene 35:577-86. PMID: 25893305
Han G, Bian L, Li F, Cotrim A, Wang D, Lu JB, Deng Y, Bird G, Sowers A, Mitchell J, Gutkind JS, Zhao R, Raben D, ten Dijke P, Refaeli Y, Zhang QH, and Wang XJ (2013). Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis. Nat Med, 19: 421-428 (highlighted by Nat Med Podcast, April, 2013)
White RA*, Neiman JM, Reddi A, Han G, Birlea S, Mitra D, Dionne L, Fernandez P, Murao K, Bian L, Keysar SB, Goldstein NB, Song N, Bornstein S, Han Z, Lu X, Wisell J, Li F, Song J, Lu SL, Jimeno A, Roop DR, Wang XJ (2013). Epithelial stem cell mutations that promote squamous cell carcinoma metastasis. J Clin Invest. 123(10):4390-404, PMID: 23999427
Mitra D, Fernandez P, Bian L, Song N, Li F, Han G, Wang XJ (2013). Smad4 loss in mouse keratinocytes leads to increased susceptibility to UV carcinogenesis with reduced Ercc1-mediated DNA repair. JID, 133:2609-166. doi: 10.1038/jid.2013.213. PMID: 23648546
Malkoski SP, Haeger SM, Cleaver TG, Rodriguez KJ, Li H, Lu SL, Feser WJ, Barón AE, Merrick D, Lighthall JG, Ijichi H, Franklin W and Wang XJ (2012). Loss of transforming growth factor type II receptor increases aggressive tumor behavior and reduces survival in lung adenocarcinoma and squamous cell carcinoma. Clin Cancer Res, 18:2173-83. PMID: 22399565 PMCID: PMC3328594
Hoot KE*, Oka M, Han G, Bottinger E, Zhang Q, and Wang XJ (2010). HGF Upregulation Contributes to Angiogenesis in Mice with Keratinocyte-Specific Smad2 Deletion. J Clin Invest, 120:3606-16.
Bornstein S*., White R*., Malkoski SP, Oka M, Han G, Cleaver T, Reh D, Anderson P, Gross N, Olson S, Deng C, Lu S, Wang XJ (2009). Smad4 Loss in Mice Causes Spontaneous Head and Neck Cancer with Increased Genomic Instability and Inflammation. J Clin Invest, 119:3408-19. PMCID: PMC2769185
Hoot KE*, Lighthall J, Han G, Lu SL, Li AG, Ju W, Kulesz-Martin M, Bottinger E, Wang XJ (2008). Keratinocyte-Specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression. J Clin Invest, 118:2722-32.PMID: 18618014 PMCID: PMC2447925

*: Graduate student thesis work

Complete publication list:

http://www.ncbi.nlm.nih.gov/sites/myncbi/xiao-jing.wang.1/bibliography/40782167/public/?sort=date&direction=ascending

Pathology (SOM)

CU Anschutz

Academic Office One

12631 East 17th Avenue

2nd Floor

Aurora, CO 80045

303-724-3704

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