I am a dual board certified anatomic and molecular pathologist with service responsibilities in the adult and children's hospitals at the University of Colorado Anschutz Medical Campus. I direct the bone and soft tissue service at the UCH adult hospital. I also have service responsibilities in the molecular pathology group at the Children's Hospital of Colorado.
Areas of Expertise
- Soft Tissue Pathology
- Molecular and Genetic Pathology
- Anatomic Pathology
- Adrenocortical carcinoma
Education, Licensure & Certifications
Fellowship training:
- Breast and Gynecologic Pathology (2013)
- Bone and Soft Tissue Pathology (2014)
- Molecular and Genetic Pathology (2015)
- Medical licenses in Colorado, Tennessee, and California.
Affiliations
- Children's Oncology Group
- Endocrine Soceity
- Association for Molecular Pathology
- International Soceity of Bone and Soft Tissue Pathologists
- American Soceity for Clinical Pathology
- College of American Pathologists
- United States and Canadian Academy of Pathology
Courses
Fellowship training:
- Breast and Gynecologic Pathology (2013)
- Bone and Soft Tissue Pathology (2014)
- Molecular and Genetic Pathology (2015)
- Medical licenses in Colorado, Tennessee, and California.
Research
I have an interest in applying molecular techniques to the diagnosis of bone and soft tissue tumors. I also study DNA-methylation arrays in the diagnosis and classification of solid tumors, including adrenocortical carcinoma and rhabdomyosarcoma.
Publications and Presentations
- XAF1 as a Modifier of p53 Function and Cancer Susceptibility. Science Advances, 2020;6(26):eaba3231.
- Benign Infiltrative Myofibroblastic Neoplasms of Childhood with USP6 Gene Rearrangement. Histopathology, 2020;10.1111.
- Route of 41BB/41BBL costimulation determines effector function of B7-H3-CAR.CD28ζ T cells. Molecular Therapy – Oncolytics, 2020;18:202-21.
- An addition to the evolving spectrum of lipofibromatosis and lipofibromatosis-like neural tumor: Molecular findings in an unusual phenotype aid in accurate classification. Pathol Res Pract. 2020 Mar 26:152942.
- Partial Response to Carboplatin, Etopophos and Atezolizumab in a Pediatric Patient with High-grade Metastatic Tumor with Neuroendocrine Features. Pediatr Blood Cancer. 2020 Feb;67(2):e28048.
- MYCN Amplification and ATRX Mutations are Incompatible in Neuroblastoma. Nat Commun. 2020 Feb 14;11(1):913.
- A single-cell and single-nucleus RNA-seq toolbox for fresh and frozen human tumors. Nature Medicine 26, 792-802, 2020.
- Forty-five patient-derived xenografts capture the clinical and biological heterogeneity of Wilms tumor. Nat Commun. 2019 Dec 20;10(1):5806
- Prognostically Significant Methylation Groups Identified in Pediatric Adrenocortical Tumors: A Report from the International Pediatric Adrenocortical Tumor Registry. JCO Precision Oncology. 2019 Nov 18:PO.19.00163
- Dedifferentiation in SDH-Deficient Gastrointestinal Stromal Tumor: A Report with Histologic, Immunophenotypic, and Molecular Characterization. Pediatr Dev Pathol. 2019 Oct;22(5):492-498.
- Li-Fraumeni Syndrome–Review and Clinicopathology of Neoplasms of the Central Nervous System. Acta Neuropathol. 2019 Aug 30.
- Therapeutic Targets in Rhabdomyosarcoma Through Integrated Genomic, Epigenomic, and Proteomic Analyses. Cancer Cell. 34, 1-16, 2018.
- Genitopatellar syndrome and neuroblastoma: the multidisciplinary management of a previously unreported association. Pediatr Blood Cancer. 2018;e27373.
- Identification of Clinical and Biological Correlates Associated with Outcome in Children with Adrenocortical Tumors without Germline TP53 Mutations: A St. Jude Adrenocortical Tumor Registry and Children’s Oncology Group Study. J Clin Oncol. 2017 Dec 10;35(35):3956-3963.
- Orthotopic patient-derived xenografts of paediatric solid tumours. Nature. 2017 Sep 7;549(7670):96-100.
