Collaboration Opportunities
At the CU Hemophilia and Thrombosis Center, our team works every day to turn research discoveries into better care for people with bleeding and clotting disorders. Below is a selection of recent publications that highlight the range of science happening at our center, from clinical studies that improve treatment and quality of life to laboratory discoveries that reveal mechanisms of disease. This list represents just a few of the many contributions our team has made to advancing care and understanding in this field.
2020-2025 Top Ten
Wischmeyer JT, Baird CH, Grandvallet Contreras J, Tran A, Phang T, Liu T, Manco-Johnson MJ. A Naturally Occurring Gain-of-Function Mutation in Factor VIII. N Engl J Med. 2025 Aug 14;393(7):722-724. doi: 10.1056/NEJMc2507228 . PMID: 40802951.
Buckner TW, Kessler C, Castaman G, Hermans C, Jiménez-Yuste V, Mahlangu J, Miesbach W, Oldenburg J, Recht M, Valentino LA, Wheeler AP, Pipe SW. Pain Reduction Following Eptacog Beta Treatment of Bleeding Episodes in Adolescents and Adults With Haemophilia A or B Complicated by Inhibitors. Haemophilia. 2025 Jul;31(4):713-721. doi: 10.1111/hae.70077. PMID: 40534395.
Cox AA, Ng CJ. Vascular-type heterogeneity is associated with differential gene expression profiles of endothelial cells under shear stress. Res Pract Thromb Haemost. 2025 May 21;9(4):102894. doi: 10.1016/j.rpth.2025.102894. PMID: 40678357.
Hermans C, Skinner MW, Gentile B, Lim E, Minhas M, Moreno K, Tzeng E, Buckner TW. Pain-Related Quality of Life Outcomes in People With Haemophilia A Receiving Emicizumab: A Post Hoc Analysis of the HAVEN 1, 3 and 4 and STASEY Studies. Haemophilia. 2025 Jan;31(1):87-98. doi: 10.1111/hae.15134. PMID: 39692401.
Cox AA, Liu A, Ng CJ. Correction: Clusterin knockdown has effects on intracellular and secreted von Willebrand factor in human umbilical vein endothelial cells. PLoS One. 2025 Mar 21;20(3):e0319850. doi: 10.1371/journal.pone.0319850. Erratum for: PLoS One. 2024 Feb 16;19(2):e0298133. doi: 10.1371/journal.pone.0298133. PMID: 40117267.
Osmond MJ, Dabertrand F, Quillinan N, Su EJ, Lawrence DA, Marr DWM, Neeves KB. Micrometer-scale tPA beads amplify plasmin generation for enhanced thrombolytic therapy. Bioeng Transl Med. 2025 Mar 3;10(4):e70012. doi: 10.1002/btm2.70012. PMID: 40708974.
Mah J, Robertson C, Mah N, Roybal J, Thornhill D, Funk S, Manco-Johnson MJ, Carollo J, Gaffney BMM, Warren BB. Joint reaction and simulated muscle forces during squatting and walking in persons with hemophilia. Clin Biomech (Bristol). 2024 Dec;120:106361. doi: 10.1016/j.clinbiomech.2024.106361. PMID: 39461281.
Jewell MP, Ashour Z, Baird CH, Manco Johnson M, Warren BB, Wufsus AR, Pallini C, Dockal M, Kjalke M, Neeves KB. Concizumab improves clot formation in hemophilia A under flow. J Thromb Haemost. 2024 Sep;22(9):2438-2448. doi: 10.1016/j.jtha.2024.05.020.. PMID: 38815755.
Ng CJ, Liu A, Venkataraman S, Ashworth KJ, Baker CD, O'Rourke R, Vibhakar R, Jones KL, Di Paola J. Single-cell transcriptional analysis of human endothelial colony-forming cells from patients with low VWF levels. Blood. 2022 Apr 7;139(14):2240-2251. doi: 10.1182/blood.2021010683. PMID: 35143643.
Warren BB, Thornhill D, Stein J, Fadell M, Ingram JD, Funk S, Norton KL, Lane HD, Bennett CM, Dunn A, Recht M, Shapiro A, Manco-Johnson MJ. Young adult outcomes of childhood prophylaxis for severe hemophilia A: results of the Joint Outcome Continuation Study. Blood Adv. 2020 Jun 9;4(11):2451-2459. doi: 10.1182/bloodadvances.2019001311. PMID: 32492157;.
Link KG, Stobb MT, Sorrells MG, Bortot M, Ruegg K, Manco-Johnson MJ, Di Paola JA, Sindi SS, Fogelson AL, Leiderman K, Neeves KB. A mathematical model of coagulation under flow identifies factor V as a modifier of thrombin generation in hemophilia A. J Thromb Haemost. 2020 Feb;18(2):306-317. doi: 10.1111/jth.14653. PMID: 31562694.