Ph.D., University of Iowa
Phone: (303) 724-3123
Seeds, N.W., B. Williams and P. Bickford (1995). Cerebellar motor learning induces tissue plasminogen activator expression in Purkinje neurons. Science 270, 1992-1994 .
Hayden, S.M. and N.W. Seeds (1996). Modulated expression of plasminogen activator system components in cultured cells from dissociated mouse dorsal root ganglia. J. Neuroscience 16, 2307-2317.
Thewke, D. and N.W. Seeds (1996). Expression of hepatocyte growth factor/scatter factor, its receptor c-met and tissue plasminogen activator in the developing olfactory system. J. Neuroscience 16, 6933-6944.
Seeds, N.W., L. Siconolfi and S. Haffke (1997). Neuronal extracellular proteases facilitate cell migration, axonal growth and pathfinding. Cell & Tissue Res. 290, 367-370.
Thewke, D, and N.W. Seeds (1998). Expression of mRNAs for HGF/SF, c-met, and tPA show a systematic relationship in the developing and adult cerebral cortex and hippocampus. Brain Res. 821, 356-367.
Seeds, N.W., S. Haffke and M. Basham (1999). Neuronal migration is retarded in mice lacking the tissue plasminogen activator gene. Proc. Nat. Acad. Sci. USA 96, 14118-14123.
Tabrizi, P., L. Wang, N.W. Seeds, et al. (1999). tPA deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model. Atheroscl. Thromb. & Vasc. Biol. 19, 2801-2806.
Seeds, N.W., S.P. Haffke and M.E. Basham (1999). Neuronal migration is retarded in mice lacking the tissue plasminogen activator gene. Proc. Nat. Acad. Sci. USA 96, 14118-14123.
Basham, M.E. and N.W. Seeds (2001). Plasminogen gene expression in neonatal and adult brain regions. J. Neurochem. 77, 318-325.
Siconolfi, L.B. and N.W. Seeds (2001). Induction of the plasminogen activator system accompanies peripheral nerve regeneration after sciatic nerve. J. Neurosci. 21, 4336-4347.
Siconolfi, L.B. and N.W. Seeds (2001). Mice lacking tPA, uPA, or plasminogen genes show delayed functional recovery after sciatic nerve crush. J. Neurosci. 21, 4348-4355.
Siconolfi, L.B. and N.W. Seeds (2003). Mice lacking tPA and uPA genes show attenuated matrix metalloproteases activity after sciatic nerve crush. J. Neurosci. Res. 74, 430-434.
Seeds, N.W., M.E. Basham and J.E. Ferguson (2003). Absence of tissue plasminogen activator gene or activity impairs mouse cerebellar motor learning. J. Neurosci. 23, 7368-7375.
Minor, K.H., L.K. Akison, H.G. Goshgarian and N.W. Seeds (2006). Spinal cord injury-induced plasticity in mouse – The crossed phrenic phenomenon. Exp. Neurol. 200, 485-494.
Minor, K.H. and N.W. Seeds (2008). Plasminogen activator induction facilitates functional recovery of respiratory function following spinal cord injury. Mol. Cell. Neurosci. 37, 143-152
Minor, K.H., J. Phillips and N.W. Seeds (2009). Tissue plasminogen activator promotes axonal outgrowth on CNS myelin after conditioned injury. J.Neurochem. 109,706-715
Fabbro, S. and N.W. Seeds (2009). Plasminogen activator activity is inhibited while neuroserpin is up-regulated in the Alzheimer disease brain. J.Neurochem. 109, 303-315
Seeds, N.W., L.K. Akison and K.H. Minor (2009). Role of plasminogen activator in spinal cord remodeling after spinal cord injury. Respir. Physiol. Neurobiol. 169, 141-149
Fabbro, S., K. Schaller and N.W. Seeds (2011). Amyloid-beta levels are significantly reduced and spatial memory defects are rescued in a novel deficient Alzheimer’s disease transgenic mouse model. J.Neurochem. 118, 928-938.
Seeds, N.W., S. Mikesell, R. Vest, T. Bugge, K. Schaller, and K. Minor (2011). Plasminogen activator promotes recovery following spinal cord injury. Cell. Mol. Neurobiol. 31, 961-967.
Subhadra, B., K. Schaller and N.W. Seeds (2013). Neuroserpin up-regulation in the Alzheimer’s disease brain is associated with elevated thyroid hormone receptor-β1 and HuD expression. Neurochem. Internat. 63, 476-481.
Please see PubMed for a complete listing of publications.