Picornavirus RNA translation and replication; hepatitis C virus and innate antiviral immunity
Phage-bacteria interactions and mobile DNA related to antibiotic resistant bacteria and the microbiota
Cell trafficking in type 1 diabetes; Immunotherapeutics development
Regulation of B cell activation
Underlying host and viral factors that limit broadly protective humoral immunity to inform next-generation influenza virus vaccine design.
Immunoregulation in autoimmune diabetes; pancreatic beta-cell autoantigens
Lymphocyte trafficking and cell-cell interactions in health and disease
Our research focuses on B cell and CD8 T cell cross-talk. Specifically, we are investigating how B cells promote CD8 T cell responses to vaccines and how they contribute to naïve CD8 T cell homeostasis.
Interactions between commensal fungi and adaptive immune responses in the gut microbiome that impact fungal commensalism, fungal virulence, and inflammatory bowel disease.
Molecular mechanisms of B cell development and selection and the development of autoimmunity
We are interested in uncovering the molecular mechanisms required for bacteria to cause infection and are focused on the intestinal pathogen Shigella flexneri
Systems Immunology and Quantitative Imaging, Host-Pathogen Interaction, Humoral and Cellular Immune Correlates