Kelly S. Doran, Ph.D., earned her doctoral degree in Biological Sciences from the University of California, San Diego, in 1998 under the mentorship of Dr. Don Helinski. She completed postdoctoral research training at the University of California, San Diego School of Medicine in the laboratory of Dr. Victor Nizet. From 2003 – 2017 Dr. Doran was a faculty member in the Department of Pediatrics at UCSD School of Medicine and beginning in 2007 the Department of Biology at San Diego State University.
Dr. Doran joined the faculty of the Department of Immunology and Microbiology at the University of Colorado School of Medicine in 2017.
The overall interest of the Doran Lab is the study of host - pathogen interactions in the central nervous system and the female reproductive tract. Our studies focus on major human pathogens including Streptococcus, Staphylococcus (MRSA), and Bacillus anthracis. Streptococcus agalactiae (also known as Group B Streptococcus, GBS), is a leading cause of invasive disease in newborns and certain adult populations including pregnant women. We seek to elucidate the mechanisms by which GBS colonizes the vaginal tract during pregnancy and penetrates the blood-brain barrier in the newborn to cause meningitis, as well as characterize host response to infection and colonization. We use a variety of molecular genetic approaches as well as cell based and animal models to identify bacterial virulence determinants and host factors that contribute to disease progression. A better understanding of these interactions is required in order to develop new therapeutic approaches to prevent GBS maternal colonization and neonatal disease.