Islet Autoantibody TestsInsulin Autoantibodies (IAA): A
micro insulin autoantibody radiobinding assay with the result expressed
as an index against the laboratory standard internal positive and
negative controls. The patients using exogenous insulin will all be
positive.
GAD65 Autoantibodies (GADA):It
is a NIH/NIDDK harmonized GAD65 autoantibody radiobinding assay with
the result expressed as DK units/ml with a NIDDK standard curve. The
test result is comparable with all ongoing NIH/NIDDK led
national/international clinical trials like TrialNet, TEDDY study, etc.
IA-2 Autoantibodies (IA-2A):NIH/NIDDK
harmonized IA-2 autoantibody radiobinding assay with the result
expressed as DK units/ml with a NIDDK standard curve. The test result is
comparable with all ongoing NIH/NIDDK led national/international
clinical trials like TrialNet, TEDDY study, etc.
ZnT8 Autoantibodies (ZnT8A):A
ZnT8 autoantibody radiobinding assay with the result is expressed as an
index against the laboratory standard internal positive and negative
controls.
Other Autoantibody TestsTransglutaminase Autoantibodies (TGA):TG
is a well known autoimmune marker for Celiac disease and multiple
studies have demonstrated that the TG levels are strongly associated
with clinical disease onset by biopsy. Among the patients with type 1
diabetes, around 8-10% are TG positive. TG test is a radiobinding assay
and the result is expressed as an index against the laboratory standard
internal positive and negative controls.
21-Hydroxylase Autoantibodies (Hyd21):Hyd21
is a specific autoimmune marker for Addison’s disease. Many patients
were initially found to have the disease because of the autoantibody
screening. Among the patients with type 1 diabetes, around 1-1.5% are
Hyd21 positive. Hyd21 test is a radiobinding assay and the result is
expressed as an index against the laboratory standard internal positive
and negative controls.
HLA Typing:We accept either whole blood (fresh or frozen) or DNA samples.
HLA DQA&B Typing
HLA DRB1 Typing
HLA A Typing
HLA B Typing
All
clinical diagnostic samples will be assigned our BDC LabID and PtID
upon receipt. The patient information will be entered into our BDC
laboratory main database including all test results. The database is
secured and has back-up system through University of Colorado IT
Services. All test results will be stored long-term and will be
retrievable.
Turn-Around TimeAutoantibody Services: Within one to two weeks
HLA Services: Within two weeks
Location:Barbara Davis Center
University of Colorado, Anschutz Medical Campus
1775 Aurora Court, 4th floor, Room M20-4201E
Aurora, CO 80045
Tel: 303-724-6809
Fax: 303-724-5811
Autoantibody/HLA contact personnel:Liping Yu, MD, Principal Investigator & Core Director
Tel: 303-724-6808