Myositis Studies

The Division of Rheumatology strives to understand more about myositis through research.  Please see the list below, which summarizes the studies available to individuals interested in advancing our understanding and treatment of rheumatic disease. 

Study Name/IRB#/PIBrief Description​Basic Eligibility​ CriteriaContact​

Break-Free - CAR-T study in SLE, IIM and SSc

24-0289

Melissa Griffith, MD


A Phase 1, Multicenter, Open-Label Study Of CC-97540 (BMS-986353), CD19-Targeted Nex-T Chimeric Antigen Receptor (CAR) T Cells, in Participants with Severe, Refractory Autoimmune Diseases: Systemic Lupus Erythematosus, idiopathic Inflammatory Myopathy or Systemic Sclerosis
  • Adult women or men (age 18 and above) with confirmed, active SLE, IIM, SSc
  • Fulfilling the 2017 EULAR/ACR classification criteria for probable(score of 5.5 without biopsies; 6.7 with biopsies) or definite  IIM (score of ≥ 7.5 without muscle biopsy and ≥ 8.7 with muscle biopsy)
  • Presence of at least 1 myositis specific (MSA), associated antibody (MAA), or ANA at screening or prior to screening.
  • Severe muscle AND/OR skin involvement.
  • Inadequate response to glucocorticoids and at least 2 of the following treatments used for at least 3 months: azathioprine, methotrexate, cyclosporin A, tacrolimus, MMF, cyclophosphamide, leflunomide, IVIG, and rituximab.
  • Other systemic autoimmune diseases (eg, multiple sclerosis, psoriasis, inflammatory bowel disease, etc) are excluded.

Mario Farag

303-724-8948

Mario[email protected]

 

JASMINE

IRB# 25-0875

Elena Weinstein, MD

Phase 3 placebo controlled clinical trial investigating the safety and efficacy of anifrolumab for the treatment of dermatomyositis (DM) and polymyositis (PM)

Eligibility:

  • Active DM/PM uncontrolled on current medication.
  • 18-75 years old.
  • Muscle biopsy confirming disease OR positive tests for antibodies associated with DM and PM.

Chong Pedrick

303-724-8948

[email protected]

Panida Khuansanguan

303-724-6542

[email protected]

 

Rheumatology

CU Anschutz

Barbara Davis Center for Diabetes

1775 North Aurora Court

3102

Aurora, CO 80045

303-724-7605

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