Lupus Nephritis Trials

The Division of Rheumatology strives to understand more about lupus through research.  Please see the list below, which summarizes the st​udies available to individuals interested in advancing our understanding and treatment of rheumatic disease.

​Study Name/IRB​#/PIBrief Description​Basic Eligibility​ CriteriaContact​

BreakFree-SLE

IRB# 25-0407

Melissa Griffith, MD

A Phase 2, Multicenter, Open-Label Study Of CC-97540 (BMS-986353), CD19-Targeted NEX-T CAR T Cells, in Participants with Active SLE (Including Lupus Nephritis) with Inadequate Response to Glucocorticoids and at Least 2 Immunosuppressants 
  • Adult women or men (age 18 and older) with confirmed, active SLE, fulfilling the 2019 ACR/EULAR classification criteria of SLE.
  • Inadequate response to GC and two or more immunosuppressant therapies.
  • Presence of anti-dsDNA, anti-histone, anti-chromatin, anti-Ro (anti-SS-A), anti-La (anti-SS-B), or anti-Sm antibodies at screening.
  • Renal biopsy within 24 months 

Primary Contact:

303-724-8948

cartrheumtrials@cuanschutz.edu

Please note that study status changes frequently and therefore, a listed study may not be actively enrolling. Also, the complete list of inclusion and exclusion criteria for a given study is often not listed due to its length.  A visit to determine an individuals eligibility may be required.  A placebo is an inactive substance or treatment that looks the same as, and is given the same way as, an active drug or treatment being tested. The effects of the active drug or treatment are compared to the effects of the placebo.

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