Rheumatoid Arthritis Research Studies

The Division of Rheumatology strives to understand more about rheumatoid arthritis (RA) through research.  Please see the list below, which summarizes the studies available to individuals interested in advancing our understanding and treatment of rheumatic disease. 


Study Name/IRB#/PIBrief Description​Basic Eligibility​ CriteriaContact​
Kevin Deane, MD
A study designed to learn more about pain in early Rheumatoid Arthritis.  It’s a 1 year study with 3 visits (baseline, 3 months, 1 year).Individuals with Rheumatoid Arthritis for less than 6 months may be eligible303-724-7510
or email
Kevin Deane, MD
Use of an approved medication (hydroxychloroquine) to prevent or stop the development of RA.  This study includes a placebo group.This study is no longer recruiting, but please contact us if you have any questions303-724-8330
or email
or visit website
​AMP​ Synovial Biopsy
Michael Holers, MD
Biopsy of joint tissue using ultrasoundEarly ​RA and patients transitioning between therapies due to poor response303-724-0581
or email
Karen Franklin


Kevin Deane, MD
To learn about the immune system and microbiome in individuals at risk for developing RAIndividuals with a positive blood test (anti-CCP antibody) or their close relatives (parents, siblings, children)303-724-8330
Or email rastudies@cuanschutz.edu
Or visit website:  www.altraproject.org
Female Influences on the Etiology of Rheumatoid Arthritis (FIERA) Study 
Kristen Demoruelle, MD, PhD
An observational study to identify the female genital tract as a potential mucosal site of initiation of autoimmunity in rheumatoid arthritis (RA).At least 18 years old and is diagnosed with RA or has a parent, sibling, or child who is diagnosed with RA303-724-7594, or email Ju Young Kwag 
Sputum Studies of Anti-Citrullinated Protein Antibodies (ACPA) and Rheumatoid Arthritis (RA) Origins [SPARO]
Kristen Demoruelle, MD, PhD
An observational study to investigate the lung as a potential site where rheumatoid arthritis (RA) is developed.At least 18 years old
Falls under one of the following criteria:
1) has a parent, sibling, or child who is diagnosed with RA
2) has a clinically confirmed RA diagnosis
3) no personal or family history of RA
303-724-7594, or email Ju Young Kwag 

Please note that study status changes frequently and therefore, a listed study may not be actively enrolling. Also, the complete list of inclusion and exclusion criteria for a given study is often not listed due to its length.  A visit to determine an individuals eligibility may be required.  A placebo is an inactive substance or treatment that looks the same as, and is given the same way as, an active drug or treatment being tested. The effects of the active drug or treatment are compared to the effects of the placebo.