Our main research goal is to understand how gene networks control cell behavior in homeostasis and human disease. Our main focus areas are human genetics, genomics, immunology and translational therapeutics.

We are a multidimensional team of biologists employing a wide range of approaches from biochemistry to functional genomics.

A major area of research in our lab is trisomy 21 and Down syndrome. Supported by the Linda Crnic Institute for Down syndrome, our research aims to elucidate the impacts of trisomy 21 at the molecular, cellular and organismal levels. More specifically, we aim to define the mechanisms by which trisomy 21 causes a different disease spectrum in the population with Down syndrome, protecting from some conditions (e.g. solid tumors, hypertension), while predisposing to others (e.g. Alzheimer’s disease, autoimmune disorders, autism).

To learn more about our science, please read visit our lab website espinosalab.org​