The Department of Pharmacology at the University of Colorado School of Medicine Anschutz Medical Campus is seeking applicants to fill tenure-track faculty positions at the Assistant Professor or Associate Professor level in the broad area of cancer research, with a focus on, but not limited to, cellular and molecular biology, basic and translational research, and/or big data methods development. The ideal candidate will have a strong track record in studying mechanisms that drive cancer development, progression, and/or metastasis using in vitro, ex vivo and/or in vivo model systems and will incorporate principles and practical applications of pharmacology in their research program.

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The Department of Pharmacology at the University of Colorado School of Medicine Anschutz Medical Campus is seeking applicants to fill tenure-track faculty positions at the Assistant Professor or Associate Professor level in the area of neuroscience, with a focus on candidates whose research program leverages, or develops novel approaches to understand nervous system function. This recruitment will be in conjunction with the NeuroTechnology Center (NTC) at the University of Colorado School of Medicine. One of the central missions of the NTC is to recruit faculty whose research is focused on developing, adapting, and implementing novel technologies to study nervous system function (both basic and translational). In this search we are seeking applicants who either use, or develop, cutting-edge molecular and cellular approaches, imaging methods, tools, sensors or probes, to study nervous system function in vitro, ex vivo and/or in vivo. The research of the applicant should emphasize molecular, cellular or circuit mechanisms that are broadly related to understanding human nervous system or associated diseases, actions of existing drugs, or the development of new drugs or therapies to treat neurological or neuropsychiatric disorders.

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This position reports directly to Dr. James Costello in the Department of Pharmacology, and will be responsible for developing computational methods to disentangle co-occurring conditions using multi-omics data in Down syndrome. The position will be jointly mentored by Dr. Casey Greene in the Department of Biomedical Informatics and is funded by the NIH, INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project. The ideal candidate will have a background in multi-omic data processing, analysis, and modeling, with a strong interest in understanding molecular mechanisms of disease. The position will be highly collaborative working with a diverse group of researchers. It will also be expected that this position will publish academic research articles and contribute to lab efforts in mentoring students, grant writing, and manuscript review.

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The Black lab is seeking postdoctoral fellows. We employ an integrated approach including functional genomics, mechanistic studies, and animal research to make biological discoveries with translational potential. Our current work is focused on understanding how DNA re-replication is regulated during development and stress and misregulated in disease states. Our studies have the potential to uncover the origins of extrachromosomal DNA and eccDNA, and provide insight into the evolution of genome structure. Our goal is to leverage these studies to identify novel therapeutic targets for the treatment of disease.

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The Black and Sullivan labs are seeking postdoctoral fellows. We employ an integrated approach including functional genomics, mechanistic studies, and animal research to make biological discoveries with translational potential. Our current work is focused on understanding how DNA rereplication is misregulated in cells with trisomy 21. This work has potential to provide new insights into the clinical impacts of trisomy 21 in people with Down syndrome, including predisposition to autoimmune conditions, Alzheimer’s Disease, and protection from solid malignancies.

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The research lab of Dr. James Costello is in search of a Bioinformatics Software Developer Research Associate to lead a project to develop and deploy software for Down syndrome research. The Costello lab, in collaboration with the research lab of Dr. Casey Greene, has a funded grant through the INCLUDE (Investigation of Co-occurring conditions across the Lifespan to Understand Down syndrome) Project to develop novel methods to process, integrate, and analyze multi-omics data in Down syndrome. The goal of this work is to leverage these data types to better understand the molecular mechanisms that give rise to co-occurring conditions in Down syndrome. The position will be highly collaborative and work with a diverse team of researchers to develop the necessary software. The ideal candidate will have a demonstrated track record in software development, preferably in the academic setting.

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