Clinical Research Training

Active areas of research/scholarly work:

• Multicenter trial evaluating platelet transfusion thresholds in extremely preterm neonates (Archambault, Delaney)
• Platelets as an inflammatory mediator in BPD, PH and pulmonary vein disease (Archambault)
• Congenital Diaphragmatic Hernia research with engagement with cross disciplinary teams in neonatology (Delaney/Wymore/Cookson/Kinsella), pediatric surgery (Derderian/Larson/Partrick), maternal fetal medicine, cardiology and radiology
• Clinical informatics (Mercado)
• Delirium screening and management in BPD patients (Hannan, Velasco, Miller, Ross)
• Timing of ASD closure and respiratory support among patients with BPD (Hannan, Mandell)
• Utilization of EIT for optimization of ventilator settings (Enzer - Pulm)
• Prospective medical and family outcomes for infants discharged from the SPROUT team (Hannan, Mandell, Houin)
• Decreasing rates of gastrostomy tube placement with initiation of comprehensive home NG program (Hannan)
• Implementation and outcomes of a universal naloxone distribution program (Bourque, Fisher)
• The effects of maternal nutrition and weight gain on neonatal outcome (Reynolds)
• Maternal cannaboid use and neonatal outcomes (Wymore)
• Telemedicine (Zenge)
• Supporting parental mental health in the NICU (Dempsey and Klawetter – Psych)

Potential Resources:

• Vermont Oxford Network (VON)
• Children’s Hospital National Consortium (CHNC).
• CU School of Public Health
• Colorado Department of Public Health
• State-of-the-art simulation facilities at the University of Colorado Center for Professional Excellence and at Children’s Hospital Colorado.
• Clinical sites include University of Colorado Hospital (UCH), Children’s Hospital Colorado (CHCO), Denver Health Medical Center, and several community hospitals in the Denver Metro area

  -    Five full-time research nurses who are dedicated to projects on maternal and neonatal health assist in coordinating patient recruitment and data collection at the UCH and CHCO.

  Colorado Clinical and Translational Sciences Institute(CCTSI)

  -    Established in 2008 with funding from the Clinical and Translational Science Award (CTSA) initiative of the National Institutes of Health (NIH).

  -    Through the CCTSI, Children’s Hospital, University of Colorado Hospital, and Denver Health Medical Center have been designated as Clinical Translational Research Centers (CTRCs)

  -    The CTRCs support research with clinical inpatient and outpatient space, inpatient research beds, nursing and research staff support, and core laboratory and nutrition services.

  -    The CTRCs also offers biostatistical collaboration/consultation for study design, including sample size and power calculations, data analysis, and manuscript preparation.

  -    To fulfill its mission to train future researchers, the CCTSI offers ongoing comprehensive educational programs in several areas, including Informatics, Biomedical Ethics, Biostatistics, and Study Design