The Tamburini lab focuses on understanding the contribution of the lymphatic vasculature to organ function during disease. We are particularly interested in the trafficking of small molecules, antigens and immune cells through the lymphatic vasculature and to the liver draining lymph nodes during chronic liver disease. We are also interested in understanding how PD-L1 reverse signaling influences the trafficking of dendritic cells through the lymphatic vasculature following infection.
We are hiring! Please inquire with firstname.lastname@example.org if you are interested in a post-doctoral fellowship within the Tamburini lab.
The overarching goal of my research program is to understand mechanisms of the lymphatic system that work to orchestrate the immune response, modulate inflammation and promote protective immunity. My lab is focused on understanding the mechanisms by which lymphatic endothelial cells acquire and retain antigens as well as recruit and interact with immune cells for the benefit of protective immunity. Recently, we identified that lymphatic growth and differentiation requires the expression of PD-L1 during an active immune response. This regulation of lymphatics via PD-L1 led us to pursue how PD-L1 could influence cell motility and viability during an active immune response. These studies peaked my interest in how the lymphatics coordinate with dendritic cells to regulate immunity and inflammation. Thus, I have begun to develop a program to understand how the lymphatic vasculature maintains tissue homeostasis in organs such as the liver. This is an exciting area as very little is understood regarding the lymphatic vasculature in the liver during chronic liver disease. Together, my current research platform requires us to understand the programming of the lymphatic vasculature and differences that occur between the tissue and lymph nodes.
I have developed three main areas of research which incorporate, immunology, molecular biology and hepatology. We aim to understand 1) mechanisms of antigen retention within lymphatic endothelial cells and the programming of the adaptive immune response; 2) regulation of dendritic cell trafficking from the tissue to the lymph node during a type 1 IFN inducing stimulus; 3) signaling pathways in response to highly oxidized low density lipoprotein that alter lymphatic function within the liver and impede liver health.
Our lab utilizes a number of programs on campus to enhance our expertise and collaborations including the GI and Liver Innate Immune Programs, the Human Immunology and Immunotherapy Initiative, the Consortium for Fibrosis Research and Translation, and the RNA Bioscience Initiative.
Complete List of Published Work in My Bibliography:
Office location: P15-10122