Patel Research: Gastrointestinal Cancer Risk and Prevention Center

• Study Objective:
  • The study is being conducted to evaluate if the combination of trivalent adenovirus-5 (Tri-Ad5) vaccines and IL-15 superagonist N-803 reduces the incidence of colorectal neoplasms.
• Who is Eligible?
  • Individuals 18+ years of age
  • Individuals with Lynch Syndrome defined by:
    • Mutation positive: MLH1, MSH2/EPCAM and MSH6 genotypes with prior history of ≥1 adenoma(s) and/or ≥1 advanced adenoma(s) and/or colon cancer(s) (but no active cancer for 6 months)
    • PMS2 genotype with prior history of colon cancer(s) (but no active cancer for 6 months)
• What does the study entail?
  • Eligible participants will receive 3-4 injections, four times, over a one-year period
  • Participants will attend study appointments
  • Participants will be asked to donate blood samples, complete a physical exam, and complete planned colonoscopies
  • For more information, visit https://clinicaltrials.gov/ct2/show/NCT05419011

 

This study is supported by the National Cancer Institute/ Division of Cancer Prevention.

• Study Objective:
  • The study is being conducted to examine colorectal cancer incidence in participants with 1-2 non-advanced adenomas at surveillance colonoscopy at 10 years compared to surveillance colonoscopy at 5 and 10 years.
• Who is Eligible?
  • Individuals 50-69 years of age
  • Undergone colonoscopy with findings of 1-2 non-advanced colon polyps
  • Are due for surveillance colonoscopy
• What does the study entail?
  • Participants receive a colonoscopy exam (either at 5 and 10 years OR 10 years)
  • Participants will be asked to donate blood and stool samples
  • Participants complete questionnaires yearly
  • For more information, visit https://clinicaltrials.gov/ct2/show/NCT05080673

 

This study is supported by the National Cancer Institute/ Division of Cancer Prevention.

• Study Objective:
  • The study is being conducted to determine how well Fecal Immunochemical Testing (FIT) works compared to colonoscopy in detecting colorectal cancer in older adults with a history of polyps.
• Who is Eligible?
  • Individuals 70 to 82 years of age
  • Individuals with a history of colorectal polyps (without history of colorectal cancer or a genetic colon cancer syndrome: e.g. Lynch, Familial Adenomatous Polyposis, or Serrated Polyposis Syndrome)
• What does the study entail?
  • Eligible participants will be randomly assigned to receive either colonoscopy or yearly FIT
  • Participants complete a yearly survey to up to 6 years
  • For more information, visit https://clinicaltrials.gov/ct2/show/NCT05612347

 

This study is supported by the Patient-Centered Outcome Research Institute (PCORI).

This is an international multicenter study designed to examine risk factors associated with early age onset colorectal cancer.

 

https://clinicaltrials.gov/ct2/show/NCT05732623?term=demetra&draw=2&rank=1 

This study is designed to understand the needs of Lynch Syndrome patients in navigating their cancer risk reduction care and how a mobile or digital health tool can help fill these needs. Participants will be interviewed in individual and group settings to understand their needs and then be invited to beta test a mobile application.

 

This is a multi-center study which will include individuals with Lynch Syndrome with the goals of (I) estimating the risk of prevalent and incident cancer among pathogenic variant (PV)/likely PV (LPV) carriers, (II) characterizing post-colonoscopy colorectal cancer (PCCRC) among PV/LPV carriers, and (III) evaluating risk factors for prevalent and incident colonic and extra-colonic neoplasia. This study will follow Lynch syndrome patients longitudinally and invite participants to be included in future research on understanding Lynch syndrome biology and interventions to prevent cancer.

For more information, visit https://clinicaltrials.gov/study/NCT06582914

This study collects blood and stool samples from patients with suspected or diagnosed Lynch syndrome and early age onsent colorectal cancer (age <55) to evaluate a deoxyribonucleic acid (DNA) screening technique for the detection of colorectal cancer.

Primary Objective: To determine the sensitivity and specificity of the multitarget stool DNA (mt-sDNA) 2.0 test, for colorectal neoplasia in high risk patients.

Secondary Objective: Develop a biorepository of samples (stool and blood) from patients with Lynch syndrome and early onset (< 55 years old) colorectal cancer.

For more information, visit https://clinicaltrials.gov/study/NCT05410977

This study evaluates the effects of dietary rice bran and common beans on gut microbiota, bile acid metabolism, and inflammatory pathways to reduce colorectal cancer risk in individuals with Lynch syndrome. Results could lead to innovative, dietary-based strategies to intercept CRC in high-risk populations and inform cancer prevention in the general population.

The aim of this study is to describe patient perceptions of gastric cancer risk and attitudes toward endoscopic surveillance. Results from this study will establish factors that influence patient decision-making and inform risk communication strategies.

This is a multicenter research collaboration designed to understand the long term outcomes among those with Hereditary Diffuse Gastric Cancer Syndrome.