University of Colorado Anschutz Medical Campus

Sandoval Lab

The Sandoval Lab conducts a variety of research studies focused on the role of the gut-brain-axis on regulating body weight
and metabolism with the aim to gain a better understanding the role of the gut-brain axis in physiology and in the pathophysiology
of obesity and Type 2 diabetes mellitus. We use a combination of techniques including genetic mouse models, bariatric surgery,
and in depth metabolic phenotype including in vivo assessment of glucose and lipid metabolism.

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PEOPLE:

PI: Darleen Sandoval, PhD D_Sandoval_Lab

Dr. Sandoval is currently Professor in Pediatrics and Medicine at University of Colorado Anschutz Medical Campus with a primary appointment in the Section of Nutrition and a secondary appointment in Endocrinology. Dr. Sandoval received her Ph.D. in Exercise Science at Arizona State University and did a Postdoctoral Fellowship at Vanderbilt University in the Division of Endocrinology. Dr. Sandoval's work focuses on the role of the gut-brain axis in regulation of metabolism. She has two general themes to this work. One is focused on understanding the role of the gut hormone glucagon-like peptide-1 (GLP-1) on glucose homeostasis and how dysregulation of GLP-1 is involved with the onset of type 2 diabetes mellitus. The other is focused on understanding the mechanisms underscoring the success of surgery, but also how bariatric surgery impact physiology. She has over 100 publications on this work and is funded by the NIH and American Diabetes Association. Dr. Sandoval has also invested considerable efforts towards Diversity Equity and Inclusion, including as Co-Founder and Co-Chair of the Women's Interprofessional Network of The American Diabetes Association. She serves as a permanent member of NIDDK-C study section and recently Co-Chaired the American Heart Association's Signaling 2 Fellowship Peer Review Committee.

Silvania da Silva Teixeira, PhD

Education:

B.S. from São Paulo State University Júlio de Mesquita Filho (UNESP), Botucatu, Brazil
Ph.D. from University of São Paulo (USP), São Paulo, Brazil
Postdoc from University of São Paulo (USP), São Paulo, Brazil

Current Position: Research Instructor

Research: I investigate the physiological and molecular mechanisms that underlie post-bariatric hypoglycemia and explore whether these changes also contribute to surgery-induced improvements in glucose homeostasis. I am also interested in the actions of thyroid hormone metabolites on metabolism.

Email: silvania.dasilvateixeira@cuanschutz.edu

Work phone: (303) 724-0619

Maigen Bethea, PhD

Education:

B.S. from Francis Marion University, Florence, SC
Ph.D. from University of Alabama at Birmingham, Birmingham, AL

Current Position: Postdoctoral Fellow

Research: I study the contribution of vagal afferent neurons to the metabolic success of bariatric surgery. I am also investigating the paracrine actions of Glp1 in the pancreas.

Email: maigen.bethea@cuanschutz.edu

Work Telephone: (303) 724-0619

Tyler Cook, PhD Tyler Cook PhD