Selected Publications

---

In mice, discrete odors can selectively promote the neurogenesis of sensory neuron subtypes that they stimulate

Kawsar Hossain, Madeline Smith, Stephen W. Santoro

February 12, 2024

We have found that exposure to male and musk odors can accelerate the birthrates of responsive OSNs, revealing that certain odor experiences can selectively "amplify" specific OSN subtypes.

REVIEW | The influence of olfactory experience on the birthrates of olfactory sensory neurons with specific odorant receptor identities

Karlin E. Rufenacht, Alexa J. Asson, Kawsar Hossain, Stephen W. Santoro

June 18, 2024

Here we review evidence and consider mechanistic and functional implications of the prospect that specific olfactory experiences (deprivation, enrichment, conditioning, and injury recovery) can regulate olfactory sensory neurogenesis rates in a subtype-selective manner.

A histological protocol for quantifying the birthrates of specific subtypes of olfactory sensory neurons in mice

Kawsar Hossain, Madeline Smith, Stephen W. Santoro

July 13, 2023

Here, we present a protocol to quantify the birthrates of specific neuron subtypes via the simultaneous detection of corresponding receptor mRNAs and 5-ethynyl-20-deoxyuridine.

Olfactory stimulation regulates the birth of neurons that express specific odorant receptors

Carl J. van der Linden, Pooja Gupta, Ashraful Islam Bhuiya, Kelci R. Riddick, Kawsar Hossain, Stephen W. Santoro

October 6, 2020

Here, using histological, single-cell, and targeted affinity purification approaches, we show that closing one nostril in mice selectively reduces the number of newly generated OSNs of specific subtypes.

Sex separation induces differences in the olfactory sensory receptor repertoires of male and female mice

Carl van der Linden, Susanne Jakob, Pooja Gupta, Catherine Dulac & Stephen W. Santoro

December 4, 2018

Here we investigate how the mouse olfactory sensory receptor repertoire changes as a function of exposure to odors emitted from members of the opposite sex, which are highly complex and sexually dimorphic.

The activity-dependent histone variant H2BE modulates the life span of olfactory neurons

Stephen W. Santoro, Catherine Dulac

December 13, 2012

We show that H2BE expression is reduced by sensory activity and that it promotes neuronal cell death, such that inactive olfactory neurons display higher levels of the variant and shorter life spans.

See our publications on PubMed

See our publications on Google Scholar