New Grants

Awarded April - August 2020


Brewer Sarah, 

 Sarah Brewer

Developing and Evaluating a Community-Based System for Rapid Dissemination of Evidence-Based Information and Research Specific to COVID-19

The long-term objective is to create a thriving community-academic partnership actively engaged in disseminating and conducting COVID-19 patient-centered outcomes and comparative effectiveness research (PCOR/CER). The purpose of this project is to develop the infrastructure necessary to achieve this goal. The specific aims are: 1) increase community stakeholder capacity for COVID-19 PCOR/CER, 2) create infrastructure for disseminating and implementing COVID-19 PCOR/CER results in the community, and 3) build community stakeholder-academic partnerships. The aims will be completed by the following objectives: 1) adapt Boot Camp Translation for rapid and virtual implementation, 2) establish a COVID-19 community action council 3) create a brief COVID-19 capacity building training, 4) develop infrastructure for community-based dissemination and implementation of COVID-19 research, 5) identify COVID-19 PCOR/CER questions, and 6) develop and disseminate a formal report on project outcomes.

Calcaterra, Susan L



Understanding Factors that Limit Access to Opioid Use Disorder Treatment in the Hospital to Inform Innovative Approaches to Expand Hospital-Based Treatment


Expanding access to medications for opioid use disorder, including buprenorphine for opioid use disorder treatment and naloxone for overdose reversal, is a critical piece in a comprehensive plan for addressing the opioid epidemic. The proposed research will contribute knowledge about existing barriers to integrating evidence-based opioid use disorder treatment in the hospital setting and aims to expand access to buprenorphine and naloxone for hospitalized patients with opioid use disorder. The proposal closely aligns with NIDA’s strategic goal to “to help people with addiction achieve a meaningful recovery”.

Dempsey, Amanda




Healthcare Worker Exposure Response and Outcomes of Hydroxychloroquine Trial (HERO-HCQ Trial) 


Severe acute respiratory syndrome coronavirus 2 associated disease or COVID-19 is caused by a novel betacoronavirus, SARS-CoV-2, that was first isolated in January 2020 and has since caused a global pandemic unseen in decades in cases and mortality. At the time of initial protocol submission in April 2020, human vaccine clinical trials had just begun and experts predicted that a vaccine would not be available until April 2021 at the earliest; therefore new measures remain desperately needed to prevent the spread of disease. In vitro studies suggest a potential moderate antiviral effect of hydroxychloroquine (HCQ) and its well-known safety profile and oral formulation make it an ideal drug candidate for prevention. The primary objective of this study is to evaluate the efficacy of HCQ to prevent COVID-19 clinical infection in healthcare workers (HCWs).

Feinstein, James


Feinstein,James (09) 2018


Development of Neuropsychiatric Adverse Events Research Platform


The primary goal of this collaboration is to develop and validate an approach to accurately identify incident pediatric neuropsychiatric events to evaluate adverse drug events in children.

Kempe, Allison


KempeAllison 200


The HPV9-10 Trial: Early Initiation of HPV Vaccination


Every year, thousands of Americans die from cancers related to human papillomavirus (HPV). The vast majority of those deaths could be prevented with a safe and effective vaccine, yet many parents choose not to have their children vaccinated when it is recommended at age 11 or 12. In this study, we will examine in a randomized trial whether earlier initiation of the vaccine at age 9-10 years will result in less parental refusal and higher rates of full vaccination at younger ages, before early sexual activity begins.

Knoepke, Christopher




Decision Support for Older and Frail Patients Considering Advanced Cardiovascular Therapies: Improving Models of Personal Values Clarification


The drive to be “person-centered” in the care of patients in advanced cardiac care is both intuitive and politically popular – enjoying explicit support from the IOM, AMA, AGS, ACC, FDA, the UN High Commissioner for Human Rights, in the Patient Protection & Affordable Care Act, and elsewhere. Optimal means by which to be patient-centered in the real-world, however, is unknown. Critically examining the ways in which healthcare providers assess patient values will be necessary to innovate the manner in which this assessment occurs and is integrated into care for patients. The overarching objective of this career development award is to continue the professional and methodologic growth of Christopher Knoepke, PhD, MSW, LCSW, into an independent clinical social work scientist leading the field of cardiology toward improved patient-centered care by means of 1) contextually-appropriate qualitative assessment of patient values in clinical settings; 2) understanding what clinical providers need in order to actually implement improved values clarification methods into practice; and 3) studying the effectiveness and implementation integration of new models of patient decision support using pragmatic trial techniques.

Masoudi, Frederick A


Masoudi, Frederick A


Effect of Hospital-Cardiologist Integration on Clinical Practice, Healthcare Quality and Medicare Spending


Understanding the effects of vertical integration on healthcare quality, patient outcomes, and cost will be of high importance to payers and policymakers, in deciding how to respond to the vertical integration trend. If we find quality improvements, this would justify investing in and encouraging vertical integration. If we find no significant effects or negative effects on quality, this would support policies that discourage integration.

Morris, Megan


Megan Morris


Improving Communication and Healthcare Outcomes for Patients with Communication Disabilities: the INTERACT Trial


In the United States, 14% of all adults report a speech, language, voice, and/or hearing disability (collectively known as communication disabilities, CD). Patients with CD experience inequities in receipt of and access to high-quality healthcare services, including primary care. Poor patient-provider communication is a significant contributor to these disparities. When healthcare providers use evidence-based communication strategies, patients with CD have improved communication outcomes and satisfaction. Unfortunately, providers rarely use these strategies in practice. We will compare the effectiveness and implementation of 2 interventions to increase primary care providers' use of communication strategies, improving the quality of their communication with patients with CD.

Toan Ong, PhD


Toan Ong


Virtual Network to Investigate the Trajectory of COVID-19-Related Severe Outcomes


This project will leverage existing collaboration among multiple health systems to pilot and understand the use and limitations of existing medical, laboratory, pharmaceutical, and vaccination records for conducting research on COVID-19. The network of collaborating sites can address gaps in our understanding of the risk of COVID-19, its complications, and eventually the effectiveness of vaccination.

Schilling, Lisa M
























iAGREE: A Multi-Center, Networked Patient Consent Simulation Study


Honoring patient preferences for sharing their electronic health records in a way that meets institutional requirements for adoption is a challenge.  Through our study, we propose to find a solution for both, which will result in a system that authenticates patients, allows them to make sharing choices, and change sharing choices based on each study’s parameters.  In addition, we will incorporate the needs and input of stakeholders (e.g., patients, institutional leaders, IRB experts) during each stage of the project.


Rapid Response Data for Discoveries: COVID-19 Clinical Data Collection to Promote Better Outcomes


The pSCANNER network includes 11 health systems, including the VA in all US states, and sites in California, Colorado, and Texas, covering over 30 million patients. The Gordon and Betty Moore Foundation funded pSCANNER to create a rapid response system to answer COVID-19 research questions. Researchers & clinicians anywhere can submit a question online and review previously asked and answered questions from a public website.


New Frontier: Using Health Care Data to Improve Population Health CHORDS


The primary goals of this project are to (1) provide aggregate data to inform the public health response to COVID and Colorado’s understanding of the impact of telehealth during COVID, (2) gain greater insights into how data partners are capturing telehealth visits in their electronic medical records, and (3) update the CHORDS data model to include codes and modifiers relevant to telehealth.

Singh, Sarguni


Singh, Sarguni


ALIGN: A Focused Palliative Care Intervention for Cancer Patients Discharging to Skilled Nursing Facilities


This study is part of a program of research that aims to improve palliative care outcomes for patients with advanced care who discharge to a skilled nursing facility (SNF) for rehabilitation after an acute care hospitalization. SNF patients with advanced cancer have high mortality rates, increased symptom burden, and low rates of future oncologic receipt after an acute care hospitalization. Identifying successful models of palliative care delivery that assist patients and caregivers with advance care planning, facilitates ongoing prognosis communication, and enables high quality communication between patients and their care teams is necessary to provide high quality care for this vulnerable population. 

Studts, Christina












Communities Helping the Hearing of Infants by Reaching Parents: The CHHIRP Navigator


Hearing loss is the most common sensory congenital disorder and this condition is diagnosable and treatable. Infants who are born with hearing loss must undergo several hearing tests to diagnose the condition, and many families are delayed in receiving this testing or never obtain the necessary testing and treatment. This study evaluates (1) whether patient navigation in state-funded clinics throughout Kentucky increases parents' follow- through with testing, (2) factors that promote or impede its delivery, and (3) cost-effectiveness of this approach.


COVID-19 effects on children who are deaf or hard of hearing and their families: Rapid and rigorous mixed-methods research to inform care


This study will assess the effects of COVID-19 on deaf/hard of hearing (DHH) children and their families, particularly on (1) access and use of hearing healthcare and related services, and (2) quality of life. Administrators and direct service providers will identify barriers and facilitators to providing services and support to DHH children and their families during the COVID-19 public health crisis. Combined results from parents and providers will be disseminated to a broad range of stakeholders to inform practice and policy to meet the needs of this vulnerable population.

Szefler, Stanley




Urban-Rural Disparities in Healthcare Quality for Children with Complex or Disabling Health Conditions


One in five American children live in rural regions, and almost 3 million of these have chronic health conditions. The overall objective of this project is to analyze three States’ all-payer claims data to comprehensively evaluate urban-rural disparities in healthcare utilization and quality for children with complex or disabling health conditions, and to identify community and health system factors associated with these disparities. This research will be the first population-level analysis to characterize the magnitude of urban-rural disparities in healthcare quality for children with chronic and disabling conditions, generating foundational knowledge to improve clinical care and public health support for this vulnerable population.

Awarded December 2019-March 2020


Heather DeKeyser, MD, MSCS


Treatment Phenotypes for Adolescents with Asthma

Technology has become available that allows for medication usage tracking for adolescents with asthma, who are at high risk for medication non-adherence. This project seeks to evaluate medication usage patterns in adolescents with asthma, utilize in-depth interview techniques to understand how to improve medication use, and create interventions tailored to each individual. We will then test these interventions to see how feasible they are for implementation in the clinical setting.

Scott Demarest

Demarest Headshot



Multi-site Validation of a Suite of Clinical Outcome Measures for Clinical Trial Readiness in the CDKL5 Deficiency Disorder

The aim of this project is to develop validated outcome measures for CDKL5 Deficiency Disorder with the goal of developing clinical trial readiness.


The Colorado Pragmatic Research in Health Conference (COPRH): Advancing Pragmatic Science for Health Services Research

The Colorado Pragmatic Research in Health Conference (COPRH): Advancing Pragmatic Science for Health Services Research aims to bring together investigators and statisticians with the goal to address issues in appropriate and effective use of pragmatic research design and methodology. Our overarching theme for the three conferences are “methods, models, and measures” for pragmatic science for health services research. The University of Colorado will host an annual national conference featuring experts in pragmatic science. Conference activities will inform design of pragmatic science capacity building tools for application of pragmatic methods and fostering team science through conference collaborations and our virtual learning community.


Awarded September-December 2019 - Highlights


Parents as their Child's Certified Nursing Aide: Evaluation of a Unique HOme Health Care Model for Children with Medical Complexity

This project aims to increase knowledge of Colorado’s Parent as their Child’s Certified Nursing Aide Program, a unique home health care model for children with medical complexity. This project is a focused research agenda designed to addresses the evidence gap in understanding of a family-centered self-management program that can be enhanced and disseminated to improve health outcomes and quality of life for patients, families, and communities.

Russell E. Glasgow, PhD

Russell E. Glasgow, PhD


Pragmatic Implementation Science Approaches to Assess and Enhance Value of Cancer Prevention and Control in Rural Primary Care

We work with rural primary care clinic partners - including their clinical staff, patients, and families - to support the rapid development, testing, and refinement of innovative approaches to implement a range of evidence-based cancer control interventions such as shared decision making around lung cancer screening and smoking cessation in ways that enhance value. We provide leadership for an Implementation Science consortium across this and other Cancer Moonshot initiatives.


Engaging practices and communities in the development of interventions to promote HPV vaccine uptake

The overall goal of this project is to engage key stakeholders with providers and researchers to develop and evaluate the impact of a novel and innovative intervention strategy for improving the uptake of HPV vaccine in the primary care setting.​


Publishing and Disseminating a National Research Agenda for CYSHCN

The current US health care system is not set up well to serve children and youth with special health care needs (CYSHCN). Comprehensive health system standards for CYSHCN have recently been developed, but these standards are seldom met. To better achieve these standards, CYSHCN deserve their own health system research focus. CYSHCNet, a national health systems research network is developing a national research agenda to help steer this work. During the past year and a half, we have gathered extensive data to develop the agenda through a rigorous, multi-stakeholder group process approach. This grant will help publish this agenda in detail and disseminate it using a multi-modal approach including: 1) creating 6 to 9 articles comprising the national research agenda and publishing them in a peer-reviewed journal supplement; 2) adapting each article to an online e-learning platform, where users can access information about research priority areas in more detail; and 3) disseminating the national research agenda using a multi-channel approach including a webinar series.​


Laura Scherer, PhD

 Laura Scherer, PhD


Evaluation of the SHARE Approach Model

The purpose of this task order is to evaluate the effectiveness of the SHARE Approach model in guiding clinicians’ shared decision-making (SDM) conversations with patients who have diverse clinical conditions and face a variety of decision-making situations. The overarching goal of the project is to learn if a generic approach to SDM such as SHARE works to improve SDM in clinical practice.   In order to answer this question, clinicians and health professionals will need to be trained in the SHARE approach and may need additional support to ensure that the approach is implemented as intended.​


Awarded April 2019-August 2019 - Highlights




David Albers, PhD




NIH - 
Mechanistic Machine Learning
Goal of this project is to develop better ways to combine data about individual patients with knowledge about physiology to create personalized forecasts and recommendations about a patient’s health. Will specifically address the management of glucose in the intensive care unit, an area of high importance that could benefit from improved forecasts and recommendations.

David Albers, PhD
- 1(GG014669)

Dynamically Tailoring Interventions for Problem-Solving in Diabetes Self-Management Using Self-Monitoring Data - a Randomized Controlled Trial

Tell Bennett, MD, MS

Tell Bennet

A Data-Driven Analysis of Pediatric Organ Dysfunction Patterns to Discover Sepsis Phonotypes

Scott Demarest, MD



Foundation for CDKL5 Research - 
AWD 194655
CDKL5 Deficiency Disorder: Development of the International CDKL5 Clinical Research Network
This is an award to establish the infrastructure necessary for a multi-site, international clinical research network – The international CDKL5 Clinical Research Network (ICCRN). The ICCRN is dedicated to the characterization of key clinical features, improvement of supportive care and development of better clinical trial ready outcome measures specific to CDKL5 Deficiency Disorder. The ICCRN led by Drs. Scott Demarest and Tim Benke, Children’s Hospital Colorado includes: Boston Children’s Hospital, Cleveland Clinic, Washington University, Children’s Hospital of Philadelphia, Columbia University, Texas Children’s Hospital and Telethon Kids in Perth, Australia and is supported by the International Foundation for CDKL5 Research.

Sean O'Leary, MD, MPH

Sean O'Leary, MD, MPH

NIH – R21AI141822 ​​Adapting Motivational Interviewing for Maternal Immunization (MI4MI)
Vaccinating pregnant women affords a unique opportunity to protect both mother and child against influenza and pertussis, yet uptake of maternal immunizations remain far below national target goals. This study will adapt motivational interviewing to the ob-gyn setting to provide information about how to improve provider communication and increase vaccine uptake among pregnant women.   
Sean O'Leary, MD, MPH

Group B Strep DBS Study

This project serves to collect data to better understand immunologic endpoints of Group B Streptococcus (GBS) disease in infected young infants. The project will help determine how and which immunologic endpoints can help with development of vaccines that target GBS. 

Laura Scherer, PhD

Laura Scherer

University of Maryland - DP2LM012890
Incorporating Bayesian reasoning into physician testing and treatment decisions
Recent research has shown that fewer than 20% of physicians understand the frequency of false positives in testing. When given an example of testing for a rare disease with a 95% specific test, most physicians answered that 95% of positive tests were true positive, whereas the correct answer was ~2%. Physicians are not trained on Bayesian thinking and as a result often significantly overestimate the positive impact of tests and treatments, which results in the harms of overdiagnosis and overtreatment. To reach our goal of reducing harms of medical care while maintaining benefits, in this project we are surveying physicians to explore factors associated with physician Bayesian reasoning and developing and testing an educational game to provide medical students (and seasoned physicians) with a fun and engaging way to improve their test interpretation accuracy.

Lisa Schilling, MD, MSPH


Bethany M. Kwan, PhD, MSPH

Headshot - Bethany Kwan


NIH- G08LM013200
 A Health Information Resource Technology to Reduce Disparities in   Transgender Health
 Using user-centered design principles, project will create an information resource for   the transgender community (TGc), including those considering, transitioning, or   currently living as transgender. Delivered through a mobile application it will provide   tailored health and well-being information, support and other yet unidentified needs   of   the TGc. Resource designed to enhance adoption, dissemination, and   sustainability.

Amy Tyler, MD  

 Amy Tyler

The ROUTT-B (Reduce Over-Utilized Tests and Treatments in Bronchiolitis) Study:
Developing a Roadmap for De-Implementation
The proposed research will advance “de-implementation” science by identifying processes and strategies to stop or reduce over-testing and over-treatment that can be broadly adapted to varied contexts and disease processes to improve the delivery of guideline concordant, evidence-based care and improve patient outcomes.

Amy Feldman, MD, MSCS

Amy Feldman

Improving Immunization Rates in Transplant Candidates Through the Use of a Health Information Technology Tool
Project investigates the barriers to immunization of pediatric transplant candidates and develops a health information technology tool to overcome these barriers, increase pre-transplant immunization rates, decrease VPIs post-transplant, and ultimately improve the health of transplant recipients. This tool has the potential to have widespread applicability to all children with chronic diseases and complex medical needs who require co-management by subspecialists and primary care providers

Channing Tate, MPH

Channing Tate (1)

NIH - R36AG064135 Underutilization of Hospice in Older African Americans
There are several potential reasons hospice is underutilized in African Americans including health literacy, lack of knowledge, mistrust in healthcare and perceived discrimination. This project addresses these barriers and evaluates if a hospice specific patient decision aid mitigates the effects of the potential barriers.


Awarded January 2019 - March 2019 - Highlights





 Vinay Kini, MD , MSHP




Noninvasive cardiovascular tests such as echocardiography and stress tests are critical to the care of patients with cardiovascular disease, but underuse and overuse of testing has led to adverse patient outcomes. This research will use a real-world approach (positive deviance) to identify effective strategies to optimize quality in the use of noninvasive cardiovascular tests. The overarching objective of this award is to ensure the growth of Dr. Vinay Kini, MD, MSHP, into an independent physician investigator who will expand knowledge in the field of cardiovascular quality by conducting research that enables optimized diagnostic testing and improved patient outcomes.


Megan Morris, PhD, MPH

 Megan Morris

Background: Patients with disabilities experience disparities in the receipt of high-qualityhealthcare services. These disparities can result when discriminatory attitudes, inaccessible physical environments, and a lack of appropriate accommodations exist. Section 1557 of the Affordable Care Act prohibits healthcare organizations (HCOs) from discriminating against patients with disabilities and mandates HCOs with 15 or more employees to designate an employee to coordinate compliance efforts. As a result, HCOs are hiring Disability Accessibility Coordinators (DACs).
Proposed Solution to the Problem: We propose developing the Learning CollaborativE to Address Disability Equity in HealthcaRe (LEADERs), a sustainable Learning Collaborative of DACs, patients with disabilities and their caregivers, and researchers across the United
States who will work together to engage in the development, conduct, and dissemination of patient-centered outcomes research (PCOR) that aims to ensure equitable care to patients with disabilities.


Prateeti Prabhaker Khazanie, MD, MPH


Variations in Use of Heart Replacement Therapies Among Patients with Advanced Heart Failure: An advanced, end-stage heart failure patient’s pathway to receiving heart replacement therapies (i.e., heart transplants or left ventricular assist devices) is dependent on 3 critical steps: (1) referral to an advanced heart failure center, (2) clinical evaluation at the center, and (3) case review by a multidisciplinary selection committee. Currently, this pathway is extremely heterogeneous between centers with no universal consensus or agreement, increasing disparities and access to potentially life-saving care for some while simultaneously exposing others to therapies that are not in line with their needs and preferences.

Lisa Schilling, MD, MSPH




The Food and Drug Administration, Center for Biologics Evaluation and Research (CBER) requirement for Biologics Effectiveness and Safety (BEST) Initiative:


Data, Tools and Infrastructure for Surveillance of Biologics. The primary goal of the contract is to expand and enhance the current CBER
capabilities with respect to data sources, infrastructure, methods, and tools and to conduct surveillance and epidemiologic studies that promote CBER's Office of Biostatistics and Epidemiology's (OBE) mission to assure the safety and effectiveness of biologic products including vaccines, blood and blood products, tissues and advanced therapeutics. The goal is to:
1. provide FDA with indirect access to large-scale United States (US) health care data of millions of patients including administrative and claims as well as electronic health records (EHR) data sources using a distributed data model and network which would require the use of a common data model (CDM).
2. build an infrastructure to provide data sources and the capability and capacity to run queries and observational studies on the data sources for CBER-regulated biologic products.
3.develop semi-automated processes for medical chart review to auagment manual review


Awarded July - December 2018


Tell Bennett, MD, MS

Tell Bennet

NIH – R03
Archiving Common Data Element-Harmonized Pediatric Traumatic Brain Injury Data and Metadata
This proposal aims to 1) harmonize data from a multi-center prospective cohort study of children with traumatic brain injury (TBI) to NIH common data elements and 2) make those data available in a federal TBI data repository and also as a free and open-source package for the R statistical programming environment.
Amanda Dempsey, MD, PhD, MPH
Amanda Dempsey
CDC – U01
Understanding and Addressing Vaccination Disparities Among Rural Adolescents
We propose to test the efficacy of a community-engaged research process, called Boot Camp Translation, for its ability to result in the development of effective strategies, products and implementation plans that increase adolescent vaccination in rural Western Colorado.

Dan Matlock, MD, MPH

 Dan Matlock sq

Implementation of Effective Shared Decision-Making Approaches in Practice Settings
The goal of this project is to implement the SDM program at all 174 LVAD programs in the United States. Our implementation will be guided by a popular theory (known as the Diffusion of Innovation Theory) to help us provide the right resources to each program.
Dan Matlock, MD, MPH

NIH – R21


Pilot Evaluation of Hospice Decision Support Tools

This project addresses this key gap in quality patient-centered care for people facing end-of-life decisions by testing the feasibility, acceptability and preliminary efficacy of a novel hospice patient decision aid developed by the study team.

Sean O'Leary, MD, MPH

Sean O'Leary, MD, MPH

NIH – R01

Evaluation of the Presumptively Initiating Vaccines and Optimizing Talk with Motivational Interviewing (PIVOT with MI) Intervention

The overall goal of this project is to evaluate the impact of a novel and innovative provider communication strategy on vaccine acceptance among vaccine-hesitant parents.

Megan Morris, PhD, MPH

Megan Morris


NIH – R21
Disparities in Patient-centered Communication Experienced by Patients with Communication Disabilities
This study will determine whether providers use less patient-centered communication with patients with a communication disorder as compared to patients without a communication disorder, and will explore the provider-level factors, including implicit and explicit biases, that could impact the communication.

Halden Scott, MD


AHRQ – K08
Enhancing Quality in Pediatric Sepsis with Shock Prediction and Early Electronic Decision Support (EQUIP with SPEED)
Predictive modeling will be utilized to improve early diagnosis of pediatric sepsis, and test the delivery of clinical decision support to clinicians through the electronic health record in an implementation trial.

Darcy Thompson, MD, MPH/MSPH


NIH – R01
Factors Influencing Screen Media Use in Low-income Mexican American toddlers
This study will provide the basis for developing culturally-tailored, family-based interventions promoting healthy screen use in early childhood in a large population at high risk for early childhood obesity.

Michael Ho, MD


Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications
This study will employ population-level pharmacy data to identify non-adherent patients and utilize cell phones to send them tailored, engaging and motivating text messages and text message based chat through an artificially intelligent (AI) interactive chat bot to improve cardiac medication adherence and patient outcomes in three integrated healthcare delivery systems.

Toan Ong, PhD

Ong, Toan

Improving Methods for Conducting PCOR
The overall goal of this project is to improve data quality (DQ) and accelerate research by lowering the technical and regulatory barriers to multi-institutional data sharing via the development of incremental privacy-preserving record linkage (PPRL) methods.


Lisa McLeod, MD



Preparing for a Hybrid Trial of Pulse Oximetry De-implementation in Stable Infants with Bronchiolitis

This project will prepare for the Eliminating Monitor Overuse (EMO) Pulse Oximetry Trial, an effectiveness-implementation trial grounded in the Consolidated Framework for Implementation Research focused on de-implementing overuse of continuous pulse oximetry monitoring in bronchiolitis.