2019 New Grants
Awarded December 2019-March 2020
| PRINCIPAL INVESTIGATOR | SPONSOR – FAIN | SUMMARY |
DeKeyser, Heather, MD, MSCS  | 25A8923 | Treatment Phenotypes for Adolescents with Asthma Technology has become available that allows for medication usage tracking for adolescents with asthma, who are at high risk for medication non-adherence. This project seeks to evaluate medication usage patterns in adolescents with asthma, utilize in-depth interview techniques to understand how to improve medication use, and create interventions tailored to each individual. We will then test these interventions to see how feasible they are for implementation in the clinical setting. |
| 25A8783 | Multi-site Validation of a Suite of Clinical Outcome Measures for Clinical Trial Readiness in the CDKL5 Deficiency Disorder The aim of this project is to develop validated outcome measures for CDKL5 Deficiency Disorder with the goal of developing clinical trial readiness. |
25A8902 | The Colorado Pragmatic Research in Health Conference (COPRH): Advancing Pragmatic Science for Health Services Research The Colorado Pragmatic Research in Health Conference (COPRH): Advancing Pragmatic Science for Health Services Research aims to bring together investigators and statisticians with the goal to address issues in appropriate and
effective use of pragmatic research design and methodology. Our overarching theme for the three conferences are “methods, models, and measures” for pragmatic science for health services research. The University of Colorado
will host an annual national conference featuring experts in pragmatic science. Conference activities will inform design of pragmatic science capacity building tools for application of pragmatic methods and fostering team science
through conference collaborations and our virtual learning community. |
Awarded September-December 2019 - Highlights
| PRINCIPAL INVESTIGATOR | SPONSOR – FAIN | SUMMARY |
R21NR018922 | Parents as their Child's Certified Nursing Aide: Evaluation of a Unique HOme Health Care Model for Children with Medical Complexity This project aims to increase knowledge of Colorado’s Parent as their Child’s Certified Nursing Aide Program, a unique home health care model for children with medical complexity. This project is a focused research agenda designed to addresses the evidence gap in understanding of a family-centered self-management program that can be enhanced and disseminated to improve health outcomes and quality of life for patients, families, and communities. | |
| P50CA244688 | Pragmatic Implementation Science Approaches to Assess and Enhance Value of Cancer Prevention and Control in Rural Primary Care We work with rural primary care clinic partners - including their clinical staff, patients, and families - to support the rapid development, testing, and refinement of innovative approaches to implement a range of evidence-based cancer control interventions such as shared decision making around lung cancer screening and smoking cessation in ways that enhance value. We provide leadership for an Implementation Science consortium across this and other Cancer Moonshot initiatives. |
R21CA230878 | Engaging practices and communities in the development of interventions to promote HPV vaccine uptake The overall goal of this project is to engage key stakeholders with providers and researchers to develop and evaluate the impact of a novel and innovative intervention strategy for improving the uptake of HPV vaccine in the primary care setting. | |
2019-02894 | Publishing and Disseminating a National Research Agenda for CYSHCN The current US health care system is not set up well to serve children and youth with special health care needs (CYSHCN). Comprehensive health system standards for CYSHCN have recently been developed, but these standards are seldom met. To better achieve these standards, CYSHCN deserve their own health system research focus. CYSHCNet, a national health systems research network is developing a national research agenda to help steer this work. During the past year and a half, we have gathered extensive data to develop the agenda through a rigorous, multi-stakeholder group process approach. This grant will help publish this agenda in detail and disseminate it using a multi-modal approach including: 1) creating 6 to 9 articles comprising the national research agenda and publishing them in a peer-reviewed journal supplement; 2) adapting each article to an online e-learning platform, where users can access information about research priority areas in more detail; and 3) disseminating the national research agenda using a multi-channel approach including a webinar series. | |
| 75P00119R00357 | Evaluation of the SHARE Approach Model The purpose of this task order is to evaluate the effectiveness of the SHARE Approach model in guiding clinicians’ shared decision-making (SDM) conversations with patients who have diverse clinical conditions and face a variety of decision-making situations. The overarching goal of the project is to learn if a generic approach to SDM such as SHARE works to improve SDM in clinical practice. In order to answer this question, clinicians and health professionals will need to be trained in the SHARE approach and may need additional support to ensure that the approach is implemented as intended. |
Awarded April 2019-August 2019 - Highlights
| PRINCIPAL INVESTIGATOR | SPONSOR – FAIN | SUMMARY |
|---|---|---|
| NIH - R01LM012734 | Mechanistic Machine Learning Goal of this project is to develop better ways to combine data about individual patients with knowledge about physiology to create personalized forecasts and recommendations about a patient’s health. Will specifically address the management of glucose in the intensive care unit, an area of high importance that could benefit from improved forecasts and recommendations. |
| Albers, David PhD | NIH/Columbia - 1(GG014669) Subcontract | Dynamically Tailoring Interventions for Problem-Solving in Diabetes Self-Management Using Self-Monitoring Data - a Randomized Controlled Trial |
| 901558 Subcontract | A Data-Driven Analysis of Pediatric Organ Dysfunction Patterns to Discover Sepsis Phonotypes |
| International Foundation for CDKL5 Research - AWD 194655 | CDKL5 Deficiency Disorder: Development of the International CDKL5 Clinical Research Network This is an award to establish the infrastructure necessary for a multi-site, international clinical research network – The international CDKL5 Clinical Research Network (ICCRN). The ICCRN is dedicated to the characterization of key clinical features, improvement of supportive care and development of better clinical trial ready outcome measures specific to CDKL5 Deficiency Disorder. The ICCRN led by Drs. Scott Demarest and Tim Benke, Children’s Hospital Colorado includes: Boston Children’s Hospital, Cleveland Clinic, Washington University, Children’s Hospital of Philadelphia, Columbia University, Texas Children’s Hospital and Telethon Kids in Perth, Australia and is supported by the International Foundation for CDKL5 Research. |
| NIH – R21AI141822 | Adapting Motivational Interviewing for Maternal Immunization (MI4MI) Vaccinating pregnant women affords a unique opportunity to protect both mother and child against influenza and pertussis, yet uptake of maternal immunizations remain far below national target goals. This study will adapt motivational interviewing to the ob-gyn setting to provide information about how to improve provider communication and increase vaccine uptake among pregnant women. |
| Sean O'Leary, MD, MPH | CDC/CDPHE-NU50CK000483 Subcontract | Group B Strep DBS Study This project serves to collect data to better understand immunologic endpoints of Group B Streptococcus (GBS) disease in infected young infants. The project will help determine how and which immunologic endpoints can help with development of vaccines that target GBS. |
| University of Maryland - DP2LM012890 Subcontract | Incorporating Bayesian reasoning into physician testing and treatment decisions Recent research has shown that fewer than 20% of physicians understand the frequency of false positives in testing. When given an example of testing for a rare disease with a 95% specific test, most physicians answered that 95% of positive tests were true positive, whereas the correct answer was ~2%. Physicians are not trained on Bayesian thinking and as a result often significantly overestimate the positive impact of tests and treatments, which results in the harms of overdiagnosis and overtreatment. To reach our goal of reducing harms of medical care while maintaining benefits, in this project we are surveying physicians to explore factors associated with physician Bayesian reasoning and developing and testing an educational game to provide medical students (and seasoned physicians) with a fun and engaging way to improve their test interpretation accuracy. |
| NIH- G08LM013200 | A Health Information Resource Technology to Reduce Disparities in Transgender Health Using user-centered design principles, project will create an information resource for the transgender community (TGc), including those considering, transitioning, or currently living as transgender. Delivered through a mobile application it will provide tailored health and well-being information, support and other yet unidentified needs of the TGc. Resource designed to enhance adoption, dissemination, and sustainability. |
| AHRQ- K08HS026512 | The ROUTT-B (Reduce Over-Utilized Tests and Treatments in Bronchiolitis) Study: Developing a Roadmap for De-Implementation The proposed research will advance “de-implementation” science by identifying processes and strategies to stop or reduce over-testing and over-treatment that can be broadly adapted to varied contexts and disease processes to improve the delivery of guideline concordant, evidence-based care and improve patient outcomes. |
| AHRQ - K08HS026510 | Improving Immunization Rates in Transplant Candidates Through the Use of a Health Information Technology Tool Project investigates the barriers to immunization of pediatric transplant candidates and develops a health information technology tool to overcome these barriers, increase pre-transplant immunization rates, decrease VPIs post-transplant, and ultimately improve the health of transplant recipients. This tool has the potential to have widespread applicability to all children with chronic diseases and complex medical needs who require co-management by subspecialists and primary care providers |
Tate, Channing,MPH
| NIH - R36AG064135 | Underutilization of Hospice in Older African Americans There are several potential reasons hospice is underutilized in African Americans including health literacy, lack of knowledge, mistrust in healthcare and perceived discrimination. This project addresses these barriers and evaluates if a hospice specific patient decision aid mitigates the effects of the potential barriers. |
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Awarded January 2019 - March 2019 - Highlights
| Congratulations! | ||
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PRINCIPAL INVESTIGATOR | SPONSOR - FAIN | SUMMARY |
| K23HL143208 | Noninvasive cardiovascular tests such as echocardiography and stress tests are critical to the care of patients with cardiovascular disease, but underuse and overuse of testing has led to adverse patient outcomes. This research will use a real-world approach (positive deviance) to identify effective strategies to optimize quality in the use of noninvasive cardiovascular tests. The overarching objective of this award is to ensure the growth of Dr. Vinay Kini, MD, MSHP, into an independent physician investigator who will expand knowledge in the field of cardiovascular quality by conducting research that enables optimized diagnostic testing and improved patient outcomes.
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| PCORI N/A | Background: Patients with disabilities experience disparities in the receipt of high-qualityhealthcare services. These disparities can result when discriminatory attitudes, inaccessible physical environments, and a lack of appropriate accommodations exist. Section 1557 of the Affordable Care Act prohibits healthcare organizations (HCOs) from discriminating against patients with disabilities and mandates HCOs with 15 or more employees to designate an employee to coordinate compliance efforts. As a result, HCOs are hiring Disability Accessibility Coordinators (DACs). Proposed Solution to the Problem: We propose developing the Learning CollaborativE to Address Disability Equity in HealthcaRe (LEADERs), a sustainable Learning Collaborative of DACs, patients with disabilities and their caregivers, and researchers across the United States who will work together to engage in the development, conduct, and dissemination of patient-centered outcomes research (PCOR) that aims to ensure equitable care to patients with disabilities. |
Prateeti Prabhaker Khazanie, MD, MPH | NIH 1K23HL145122-01 | Variations in Use of Heart Replacement Therapies Among Patients with Advanced Heart Failure: An advanced, end-stage heart failure patient’s pathway to receiving heart replacement therapies (i.e., heart transplants or left ventricular assist devices) is dependent on 3 critical steps: (1) referral to an advanced heart failure center, (2) clinical evaluation at the center, and (3) case review by a multidisciplinary selection committee. Currently, this pathway is extremely heterogeneous between centers with no universal consensus or agreement, increasing disparities and access to potentially life-saving care for some while simultaneously exposing others to therapies that are not in line with their needs and preferences. |
| IQVIA-Colorado-10023I | The Food and Drug Administration, Center for Biologics Evaluation and Research (CBER) requirement for Biologics Effectiveness and Safety (BEST) Initiative:
Data, Tools and Infrastructure for Surveillance of Biologics. The primary goal of the contract is to expand and enhance the current CBER |
