Residential Pathway Faculty

Mark Mañago PT, DPT, PhD, NCS

Assistant Professor

Physical Therapy (SOM)
Core Faculty

Email Address:mark.manago@cuanschutz.edu

View CU Doctors Profile

Areas of Expertise

Neurologic physical therapy

Education, Licensure & Certifications

University of Colorado Denver Graduate School, Anschutz Medical Campus, Aurora, CO
PhD, Clinical Science, 2018

University of Colorado, Denver Health Sciences Center, Aurora, CO
Doctor of Physical Therapy, 2008

University of Colorado, Denver Health Sciences Center, Denver, CO
MS, Physical Therapy, 2005

Carleton College, Northfield, MN
BA, Spanish Literature, 1997

Licensure Information/Registration Number:
Colorado #8935, 2005-present

Certifications:
Neurologic Clinical Specialist, American Board of Physical Therapy Specialties, 2009
Advanced Credentialed Clinical Instructor, American Physical Therapy Association, 2011
Credentialed Clinical Instructor, American Physical Therapy Association, 2007
Credentialed Medical Interpreter (Spanish), University of Colorado Hospital, 2005

Resumes/CV:

Manago CV 05.2024 docx

Awards

Top Platform, Degenerative Disease Special Interest Group, American Physical Therapy Association Combined Sections Meeting, 2023.

Top abstract by a trainee, Eighth International Symposium on Gait and Balance in Multiple Sclerosis: Sensory Contributions to Gait and Balance. Oregon Health & Science University, Portland, OR. 2018.

President’s Fund for the Humanities Award, Office of Academic Affairs, University of Colorado.

Herndon Award for Outstanding Article in the International Journal of MS Care. Recognizes the best article published in the journal, 2017.

Top abstract by a trainee, Sixth International Symposium on Gait and Balance in Multiple Sclerosis: Sensory Contributions to Gait and Balance. Oregon Health & Science University, Portland, OR. Sept 9-10, 2016.

Chancellor Diversity Scholarship, School of Medicine, University of Colorado Denver Health Sciences Center, 2004.

Courses

Teaching Responsibilities

Fall
DPTR 5621 Evidence Based Practice, Course Coordinator
DPTR 6632 Clinical Reasoning II, Instructor

Spring
DPTR 5631: Clinical Reasoning I, Instructor
DPTR 6633: Clinical Reasoning III, Instructor

Summer
DPTR 6502: Neuromuscular Conditions II, Lecturer
DPTR 7651: Clinical Reasoning Capstone, Instructor
DPTR 7641: Integrated Practice, Instructor

Research

Research Profile

Current:

NIH/NINDS 1U01NS113851 | Corcos (PI) 9/25/19-07/31/24
Role: Outcomes Assessor
Effort: 5%
Study in Parkinson disease of exercise Phase III clinical trial: SPARX3
The study goal is to establish the efficacy of high-intensity endurance exercise as first-line therapy for recently diagnosed people with Parkinson's disease (PD). ($90,118 annual total award, site)

IK2 RX004242-01 | Mañago (PI) 01/03/23-12/31/28
Role: Principal Investigator
Effort: 62.5%
Low-Load Resistance Training with Blood Flow Restriction in People with Multiple Sclerosis and Advanced Disability: A Randomized Control Trial
The goal of this project is to determine the efficacy of low-load resistance training using blood flow restriction on muscle strength and morphology in people with MS and more advanced disability. ($802,049)

Davis Phinney Foundation Award | Mañago (PI) 04/1/23-06/30/24
Role: Principal Investigator
Effort: 10%
Feasibility of low-load resistance training with blood flow restriction in people with advanced disability due to Parkinson’s disease
The goal of this project is to determine the feasibility of low-load resistance training using blood flow restriction in people with PD and more advanced disability. ($99,121)

NMSS MB-2205-39515 | Fling (PI) 7/1/2023-6/30/2028
Role: Co-Mentor
Effort: N/A
National MS Society Mentor Based Postdoctoral Fellowships
From bench to bedside - mobility control and neurorehabilitation in people with multiple sclerosis
This award provides multi-year support for a mentor-institution combination to train young clinician scientists to conduct MS-specific rehabilitation research. ($497,901.25)

Completed:
NIH K12 HD055931 | Mueller (PI) | 09/01/2020-08/31/22
Role: Scholar, Project PI
Proximal resistance training to improve walking capacity and physical activity in people with multiple sclerosis.
The objectives of this study are to determine feasibility and limited efficacy of a resistance training intervention targeting proximal muscles on walking function, movement patterns, and activity behaviors in people with MS. ($257,000)

Consortium of Multiple Sclerosis Centers Pilot Award | Mañago (PI) | 03/1/21-02/28/22
Role: Principal Investigator
Feasibility of low-load resistance training using blood flow restriction for people with multiple sclerosis and marked mobility restriction
The goal of this project is to determine the feasibility of low-load resistance training using blood flow restriction in people with MS and more advanced disability. ($40,000)

NIH/NINDS 1U01NS113851 | Corcos (PI) | 09/25/19-07/31/24
Role: Outcomes Assessor
Study in Parkinson disease of exercise Phase III clinical trial: SPARX3
The study goal is to establish the efficacy of high-intensity endurance exercise as first-line therapy for recently diagnosed people with Parkinson's disease (PD) ($90,118 annual total award, site)

Paralyzed Veterans of America Education Foundation Grant | 6/1/2020– 5/31/2021
Role: PI
10th International Symposium on Gait and Balance in Multiple Sclerosis
This grant provided partial support for an annual 1 ½ day multidisciplinary educational meeting focused on gait and balance in multiple sclerosis. ($15,000)

University of Colorado PM&R Pilot Award | Mañago (PI) | 09/1/18-08/31/19
Role: Principal Investigator
Instrumented Motion Analysis of Hip and Trunk Movement Compensations for People with Multiple Sclerosis
The goal of this project is to evaluate hip and trunk biomechanical compensatory strategies during functional activities in patients with multiple sclerosis. ($10,000)

Other Research Activity:

Outcome assessor (Ongoing). A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study of ACE-083 in Patients with Facioscapulohumeral Muscular Dystrophy

Outcome assessor (Ongoing). A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study of ACE-083 in Patients with Charcot-Marie-Tooth Disease Types I and X

Data Collection and Site Coordinator. Baert I, Smedal T, Kalron A, et al. Responsiveness and meaningful improvement of mobility measures following MS rehabilitation. Neurology. October 2018:10.1212/WNL.0000000000006532. doi:10.1212/WNL.0000000000006532

Outcome assessor. A Phase 2, Double-Blind, Randomized, Placebo-Controlled, Multiple Dose Study of CK-2127107 in Two Ascending Cohorts of Patients with Spinal Muscular Atrophy (SMA). 2017.

Treating physical therapist. Stevens-Lapsley JE, Balter JE, Wolfe P, Eckhoff DG, Kohrt WM. Early Neuromuscular Electrical Stimulation to Improve Quadriceps Muscle Strength After Total Knee Arthroplasty: A Randomized Controlled Trial. Phys Ther. 2011;92: Nov 17.
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Publications and Presentations

Scholarly Agenda

To advance clinical research in the field of rehabilitation in people with multiple sclerosis and other neurological conditions by investigating clinically feasible targeted exercise interventions to improve participation. To apply novel methods of instruction into the application of evidence based practice and interpretation of the medical literature; and subsequently to evaluate those methods via research into learning outcomes and educational effectiveness.

Within the last five years

Peer Reviewed Publications

Mañago MM, Kimbrell K, Hager ER, Dwight H, Owens J, Bade MJ. Clinical use of blood flow restriction in people with neurologic conditions: A cross-sectional survey. Journal of Physical Therapy Science. 2022;(In Press).

Kline PW, Christiansen CL, Judd D, Mañago MM. Clinical Utility of the Trendelenburg Test in People with Multiple Sclerosis. Physiotherapy Theory and Practice. 2022. doi: http://dx.doi.org/10.1080/09593985.2022.2030446

Shields RK, Benchmarking Research Advances Value in Education (BRAVE) Group, Dudley-Javoroski S. Benchmarking in Academic Physical Therapy: A Multicenter Trial Using the PT-GQ Survey. Physical Therapy. Published online September 27, 2021:pzab229. doi:10.1093/ptj/pzab229

Mañago MM, Swink LA, Hager ER, Gisbert R, Earhart GM, Christiansen Cl, Schenkman M. The Impact of COVID-19 on Community-Based Exercise Classes for People with Parkinson Disease. Physical Therapy. 2021. doi:10.1093/ptj/pzab203

Mañago MM, Kline PW, Harris-Love MO, Christiansen CL. The Validity of the Single-Leg Heel Raise Test in People With Multiple Sclerosis: A Cross-Sectional Study. Front Neurol. 2021;12:650297.

Canham LE, Mañago MM, Dannemiller L, Rapport MJ. Holistic Review in Doctor of Physical Therapy Admissions Can Lead to Enhanced Diversity in Admitted Students. Journal of Physical Therapy Education. 2021;35(3):195-202. ñ

Kline PW, Christiansen CL, Hager ER, Alvarez E, Mañago MM. Movement compensations during a step ascent task are associated with stair climbing performance in people with multiple sclerosis. Gait & Posture. 2021;87:27-32.

Maugeri G, D’Agata V, Roggio F, Cortis C, Fusco A, Foster C, Mañago MM, Harris-Love MO, Vleck V, Piacentini MF, Musumeci G.. The “Journal of Functional Morphology and Kinesiology” Journal Club Series: PhysioMechanics of Human Locomotion. JFMK. 2020;5(3):52.

Mañago MM, Kline PW, Alvarez E, Christiansen CL. Trunk and pelvis movement compensation in people with multiple sclerosis: Relationships to muscle function and gait performance outcomes. Gait & Posture. 2020;78:48-53.

Mañago MM, Callesen J, Dalgas U, Kittelson J, Schenkman M. Does disability level impact the relationship of muscle strength to walking performance in people with multiple sclerosis? a cross-sectional analysis. Multiple Sclerosis and Related Disorders. 2020;42:102052.

Mañago MM, Cameron M, Schenkman M. Association of the Dynamic Gait Index to fall history and muscle function in people with multiple sclerosis: A secondary data analysis. Disability and Rehabilitation. Under Review.

Mañago MM, Hebert JR, Kittelson J, Schenkman M. Feasibility of a targeted strengthening program to improve gait in people with multiple sclerosis: a brief report. Int J Rehabil Res. 2018:41(4);364-367. doi:10.1097/MRR.0000000000000306

Mañago MM, Glick S, Hebert JR, Coote S, Schenkman M. Strength Training to Improve Gait in People with Multiple Sclerosis: A Critical Review of Exercise Parameters and Intervention Approaches. International Journal of MS Care. 2019;21(2):47-56.

Mañago MM, Hebert JR, Kittelson J, Schenkman M. Contributions of Ankle, Knee, Hip, and Trunk Muscle Function to Gait Performance in People With Multiple Sclerosis: A Cross-Sectional Analysis. Phys Ther. 2018:98(7);595-604. doi:10.1093/ptj/pzy048

Mañago MM, Hebert JR, Schenkman M. Psychometric Properties of a Clinical Strength Assessment Protocol in People with Multiple Sclerosis. International Journal of MS Care. 2017;19(5):253-262. doi:10.7224/1537-2073.2016-078.

Hebert JR, Mañago MM. Reliability and Validity of the Computerized Dynamic Posturography Sensory Organization Test in Persons with Multiple Sclerosis. International Journal of MS Care. 2017;19(3):151–157. doi: 10.7224/1537-2073.2016-027

Published Abstracts of Peer Reviewed Presentations

Mañago MM, Kimbrell K, Hager ER, Dwight H, Bade MJ. Application and Perceptions of Blood Flow Restriction in People with Neurologic Conditions: A Practitioner Survey. Abstract from the American Physical Therapy Association Combined Sections Meeting. Journal of Neurologic Physical Therapy. 2022;46(1):51-53.

Dwight H, Hoffman R, Cohen ET, Owens J, Bade MJ, Mañago MM. Blood Flow Restriction for a Patient with Multiple Sclerosis and Advanced Disability: A Case Report. Abstract from the American Physical Therapy Association Combined Sections Meeting. Journal of Neurologic Physical Therapy. 2022;46(1):51-53.

Hoffman, RM, Christiansen, CL, Mañago MM. Responsiveness of the Patient-Specific Functional Scale to Changes in Walking Endurance: A Proof-of-Concept Analysis. Poster Abstracts from the 10th International Symposium on Gait and Balance in Multiple Sclerosis. International Journal of MS Care. 2021;23(1):45-46.

Mañago MM, Callesen J, Dalgas U, Kittelson J, Schenkman M. The impact of disability level on the relationship of muscle strength to walking capacity in people with multiple sclerosis. Multiple Sclerosis Journal. 2020;26(2S):15-16.

Mañago MM, Alvarez E, Kline P, Christiansen C. Proximal movement compensations are related to muscle function and walking capacity in people with multiple sclerosis. Poster abstract from the Consortium of Multiple Sclerosis Annual Meeting. International Journal of MS Care. 2020;22(2):74.

Kline PW, Christiansen CL, Hager ER, Mañago MM. Clinical Utility of the single-leg calf raise test in people with multiple sclerosis. Platform abstract from the American Physical Therapy Association Combined Sections Meeting. Journal of Neurologic Physical Therapy. 2020;44(1):104-5.

Kline PW, Christiansen CL, Hager ER, Mañago MM. Proximal frontal plane movement compensations during gait and step-ups in people with multiple sclerosis. Poster abstract from the Ninth International Symposium on Gait and Balance in Multiple Sclerosis. International Journal of MS Care. 2020;22(2):100-1.

Zaffarano B, Mañago M. Trigger point dry needling in a person with multiple sclerosis and functional mobility impairments: a case report. Poster abstract from the Ninth International Symposium on Gait and Balance in Multiple Sclerosis. International Journal of MS Care. 2020;22(2):100-1.

Mañago MM, Hebert JR, Schenkman M. Strengthening of Ankle, Hip, and Trunk to Improve Gait in People with Multiple Sclerosis: a Feasibility Study. Poster Abstracts from the Eight International Symposium on Gait and Balance in Multiple Sclerosis. Sept 15, 2018. Int J MS Care. 2018; 20(6):298-299.

Mañago MM, Hebert JR, Schenkman M. The utility of handheld dynamometry and clinical strength assessments in people with multiple sclerosis. JNPT. 2017;41(1):75-88.

Peer Reviewed Scientific and Professional Presentations (not previously cited above under abstracts)

Hinrichs L, Rodriguez J, Nordon-Craft A, Manago M, McDevitt A, Judd D. Blocked scheduling in Physical Therapist education as a curricular adjustment in response to COVID-19 [poster presentation] American Physical Therapy Association Combined Sections Meeting. San Antonio, TX: 2022.

Duncan R, Mañago MM. Pain in Neurodegenerative Disease: Why We Should Pay Attention [Education Session]. Academy of Neurologic Physical Therapy Conference [Virtual], Oct 2021.

Mañago MM, Swink LA, Hager ER, Gisbert R, Earhart GM, Christiansen Cl, Schenkman M. Community-based exercise class participation for people with Parkinson’s disease and their class instructors during COVID-19. Academy of Neurologic Physical Therapy Conference [Virtual], Oct 2021.

Hoffman, RM, Christiansen, CL, Mañago MM. Psychosocial Aspects of Perceived Fatigue are Associated with Mobility Outcomes in People Multiple Sclerosis [Poster]. Academy of Neurologic Physical Therapy Conference [Virtual], Oct 2021.

Swink, LA, Schenkman M, Christiansen CL, Hager ER, Earhart GM, Gisbert R, Mañago MM. Exercise patterns in a virtual world: Barriers and needs for people with Parkinson’s disease during the COVID-19 pandemic [Poster]. Occupational Therapy Summit of Scholars, June 2021.

Kline PW, Christiansen CL, Hager ER, Mañago MM. Compensations during step ascent contribute to stair climbing ability in multiple sclerosis [Poster]. American Society of Biomechanics Annual Meeting, Aug 2020.

Canham L, Dannemiller L, Mañago M, Rapport MJ. Using a Holistic Review in Admissions: One Programs’ Experience in Enhancing Diversity. [Platform] American Physical Therapy Association Combined Sections Meeting. Denver, CO, Feb 2020.

Ott J, Mañago M. Balance, falls, and patient reported outcomes before and after deep brain stimulation in Parkinson’s disease: A pilot study. [Poster Presentation] American Physical Therapy Association Combined Sections Meeting. Denver, CO, Feb 2020.

Mañago M. New Insights into Muscle Function for Gait in People with Multiple Sclerosis. American Physical Therapy Association NEXT Meeting [Educational Session]. Chicago, IL. June 12-15, 2019.

Mañago M. Coote S, Hebert JR, Schenkman M. A Critical Review of Strength Training to Improve Gait in People with Multiple Sclerosis: Exercise Parameters and Intervention Approaches [Platform]. World Congress of Physical Therapy. Geneva, Switzerland. May 10-13, 2019.

Other Publications

Mañago MM, Gisbert R. Kahlo and Beyond: The Importance of Art and Medical Humanities in Physical Therapy. Phys Ther. 2017;97(11):1114. doi:10.1093/ptj/pzx084.

Non-Peer Reviewed Presentations

Mañago M. Physical Therapy Management in Amyotrophic Lateral Sclerosis. Muscular Dystrophy Association ALS Summit. University of Colorado Hospital. Aurora, CO; November 4th, 2017.

Mañago, M, Jordan, S. Sawyer, E. Are you Up to Date on Electrotherapy and Other Modalities? Evidence and Clinical Decision Making: Choosing Wisely. University of Colorado Denver Physical Therapy Program Clinical Instructor Update Series. Aurora, CO; June 2017.

Other Invited Presentations:
Mañago M, Cameron M. Research in the VA Environment: Career Development Awards & Mentoring. Multiple Sclerosis Centers of Excellence (MSCoE) West Regional Meeting [Virtual]. June 25, 2021.

Mañago M. Staying active with multiple sclerosis: Physical therapy and beyond. Rocky Mountain MS Center Empower Lecture Series [Virtual]. Rocky Mountain MS Center. Denver, CO; December 18, 2020.

Mañago M. Ask the Experts ALS Panel. ALS Association Experts Symposium. Denver, CO; October 11, 2020.

Mañago M. Rehabilitation for Fatigue in People with Multiple Sclerosis. 10th International Symposium on Gait and Balance Patient Seminar [Virtual]. National Multiple Sclerosis Society. Denver, CO; October 2th, 2020.

Mañago M. Proximal Movement Compensations During Walking in People with Multiple Sclerosis. 33rd Annual Gersten Day Scientific Symposium. University of Colorado Anschutz Medical Campus. Aurora, CO; June 12, 2020.

Mañago M. Clinical Mobility Measurement. Invited Guest Lecturer, Colorado State University HES 704B: Advanced Topics in Bioenergetics: Mobility Impairment and Exercise Interventions in Clinical Populations. Jan 29, 2020.

Mañago M. Using Technology for Monitoring Mobility in Persons with Multiple Sclerosis: How, What, and Why. 9th International Symposium on Gait and Balance Patient Seminar. National Multiple Sclerosis Society. Denver, CO; October 4th, 2019.

Manago M. Physical Therapist Management of Charcot Marie Tooth’s Disease, Fascio-Scapular Humeral Muscular Dystrophy, and Inclusion Body Myositis. University of Colorado Department of Neurology Neuromuscular Symposium. University of Colorado Anschutz Medical Campus. Aurora, CO; September 28, 2019.

Manago M. Physical Therapist Management in Fascio-Scapular Humeral Muscular Dystrophy. World FSHD Day Colorado Chapter Meeting. University of Colorado Anschutz Medical Campus. Aurora, CO; June 20th, 2019.

Manago M. Targeted Strength Training to Improve Gait in People with Multiple Sclerosis. Aarhus University, Department of Public Health, Section of Sport Science. Aarhus, Denmark. May 29th, 2019.

Manago M. Physical Therapy Management in Amyotrophic Lateral Sclerosis. Muscular Dystrophy Association ALS Summit. University of Colorado Hospital. Aurora, CO; November 4th, 2017.

Mañago, M, Jordan, S. Sawyer, E. Are you Up to Date on Electrotherapy and Other Modalities? Evidence and Clinical Decision Making: Choosing Wisely. University of Colorado Denver Physical Therapy Program Clinical Instructor Update Series. Aurora, CO; June 2017.

Physical Therapy (SOM)

CU Anschutz

Education II South

13121 East 17th Avenue

3106

Aurora, CO 80045

303-724-2878

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