Green Lab

Thank you for visiting the website for the Green Laboratory, part of the Morgan Adams Foundation Pediatric Brain Tumor Research Program at the University of Colorado School of Medicine and Children’s Hospital Colorado, on the Anschutz Medical Campus.

The focus of the Green Lab is on addressing unmet needs in childhood brain tumor treatment through translational research approaches. We investigate novel targets and therapeutic strategies in the treatment of pediatric high-grade glioma (PHGG), including diffuse intrinsic pontine glioma (DIPG)/diffuse midline glioma (DMG) and radiation-induced glioma (RIG). . These tumors together represent the number one cause of death in childhood cancer and are highly resistant to current treatments. We use a variety of high-throughput methods, including shRNA screening, drug screening, and next-generation sequencing to identify weaknesses in these tumors. We then attempt to exploit these weaknesses through cell culture and mouse models, with the goal of bringing the most effective new therapies to rationally-designed early-phase clinical trials. There are several trials currently open or in development based on work from our lab. We are also interested in treatment resistance, novel drug delivery methods, and combination therapies.

View public data from published papers.

We are grateful for funding support from the Morgan Adams Foundation, National Institute of Neurologic Disorders and Stroke, St. Baldrick’s Foundation, Alex’s Lemonade Stand Foundation, Hyundai Hope on Wheels, The Cure Starts Now, , the American Cancer Society, the Olivia Caldwell Foundation/Stella Strong, University of Colorado Cancer Center, Cancer League of Colorado, the DIPG/DMG Research Funding Alliance, the Musella Foundation, the Mithil Prasad Foundation, CureSearch, and TeamConnor.