We use state-of-the-art, transformational research platforms to decipher the unique biology and disease spectrum caused by trisomy of chromosome 21.
Our ultimate goal is to enable precision medicine approaches to improve health outcomes in Down syndrome, including the development of new diagnostic and therapeutic tools.
We are the largest geographical cluster of Down syndrome researchers in the world
Comprised of over 50 Principal Investigators and countless more contributing scientists from across the University of Colorado campuses, our researchers bring expertise from a variety of fields.
Together, we are working to decipher the complex mechanisms and multi-faceted health impacts of trisomy 21.
NIH announces relaunch of DS-Connect®: The Down Syndrome Registry
Last year, DS-Connect temporarily paused operations as NIH made plans for a refresh, selecting the University of Colorado Denver as the registry’s new service provider.
Dr. Joaquin Espinosa featured in the Washington Post
Dr. Joaquin Espinosa, executive director of the Crnic Institute, discusses the devastating condition known as Down syndrome regression disorder (DSRD) and the exciting new clinical trial investigating potential treatments.
The Human Trisome Project - Latin America Network is a unique collaboration between the Linda Crnic Institute for Down Syndrome and multiple hospitals and universities across Latin America.
Breakthrough Study Reveals Molecular Subtypes of Down Syndrome
The research identifies distinct molecular and immune subtypes across individuals with Down syndrome, offering new insights for personalized medicine approaches.
We need partners like you to grow and accelerate our work
Ours is a mission that was never meant to be
accomplished alone. We are grateful for our scientists, business partners, generous donors, and brave
research volunteers, and we cannot continue moving forward without your
sustained support.