Grand Challenge Grants

The Crnic Grand Challenge Grants Program is designed for faculty-rank investigators at the University of Colorado and awards up to $50,000 for research focused on Down syndrome.

Man standing on cliff looking over a valley


This Request for Applications (RFA) is issued by the Linda Crnic Institute for Down Syndrome to support the submission of grant proposals to the NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project. 

Applicants should have already submitted a grant proposal to NIH in the field of Down syndrome research and be planning to resubmit in response to an INCLUDE Project RFA or Notice of Special Interest (NOSI). Applicants should have notification from NIH that the grant will not be funded and have plans to revise and resubmit an improved proposal addressing concerns raised during peer review by an NIH study section. Grant proposals should propose defined research projects that will further our understanding of key Down syndrome phenotypes or co-morbidities and advance the mission and vision of the Crnic Institute, as well as the INCLUDE Project and the larger Down syndrome research community.

Award Information

Awards are up to $50,000 and no indirect costs are provided. A budget is not required for application.

Award Timeline

Applications are due November 1, 2021

Funding decisions will be communicated to applicants December 1, 2021

Funding of successful applicants begins January 1, 2022.


Please contact​​.

Linda Crnic Institute for Down Syndrome

CU Anschutz

Research Complex II

12700 East 19th Avenue

Room 4014

Aurora, CO 80045


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