Faculty

Mary Allen, PhD

​​Research Assistant Professor, BioFrontiers Institute​​

Function of RUNX1 in multiple Down syndrome tissues 

Thomas Blumenthal, PhD

Professor Emeritus, Molecular, Cellular, and Developmental Biology

Protein biomarkers associated with common Down syndrome comorbidities

David Bentley, PhD

Professor, Biochemistry and Molecular Genetics

Trisomy 21 and RNA polymerase II function

Mair ​Churchill, PhD

Professor, Pharmacology

Investigation of Chromatin Assembly Factor 1 B in Down syndrome neurons

Angelo D’Alessandro, PhD

Assistant Professor, Biochemistry and Molecular Genetics

Metabolic alterations of trisomy 21​

James DeGregori, P​hD

Professor, Biochemistry and Molecular Genetics

Down syndrome as a systemic autophagy deficiency disorder

Robin Dowell, PhD

Associate Professor, Molecular, Cellular, and Developmental Biology

Transcriptional and post-transcriptional regulation in Down syndrome​

Ken Maclean, PhD      

Professor, Pediatrics

Interaction between arsenic and trisomy 21 in tissue regeneration 

Amy Palmer, PhD      

Professor, Biochemistry

Zinc deficiency in Down syndrome

Roy Parker, PhD

Distinguished Professor, Biochemistry

White matter loss in Down syndrome: a consequence of altered protein biosynthesis?​​

Chad Pearson, PhD

Assistant Professor, Cell and Developmental Biology

Ciliary trafficking defects and cerebellar hypoplasia in Down syndrome

Rytis Prekeris, PhD

Professor, Cell and Developmental Biology 

Cortical remodeling and ciliogenesis in Down syndrome

James Roede, PhD

Assistan​t Professor, Pharmaceutical Sciences​

Andrew Thorburn, PhD

Professor, Pharmacology

Down syndrome as a systemic autophagy deficiency disorder

Jason Aoto, PhD

Assistant Professor, Pharmacology

Brianna Bettcher, PhD

Assistant Profe​​ssor, Neurosurgery

Inflammation-related cognitive and ​neuroanatomical bases of Down syndrome​​

Ulrich Bayer, PhD

Professor, Pharmacology

Molecular mechanisms of defects in neurogenesis and neuronal migration

Mark Dell’Acqua, PhD

Professor and Vice Chairman, Pharmacology

Amyloid beta postsynaptic signaling through anchored calcineurin

Deborah Fidler, PhD

Professor, Human Development and Family Studies (CSU)

Executive function and goal-directed behavior in Down syndrome

Charles Hoeffer, PhD

Assistant Professor, Integrated Physiology

RCAN1 and cognition, sleep, and circadian function in Down syndrome 

Kevin Jones, PhD

Associate Professor, Molecular, Cellular, and Developmental Biology

BDNF augmentation as a therapeutic treatment for Down syndrome​

Matthew Kennedy, PhD

Assistant Professor, Pharmacology 

Impact of the beta amyloid on synaptic plasticity and dendritic function

Wendy Macklin, PhD

Professor and Chair, Cell and Developmental Biology

CNS myelination in a mouse model of Down syndrome

Steven Maier, PhD

Distinguished Professor, Psychology and Neuroscience

The role of microglia in cognitive alterations in Down syndrome​

William Old, PhD

Assistant Professor, Molecular, Cellular, and Developmental Biology

Lina Patel, PsyD

Assistant Professor, Psychiatry

Autism, mood dysregulation, and anxiety in Down syndrome

Huntington Potter, PhD

Aneuploidy and amyloid in Down syndrome Alzheimer's disease​

Tamim Shaikh, PhD

Associate Professor, Pediatrics

Matthew Burchill, PhD

Assi​stant Professor, Medicine-Gast​roenterology and Hepatology

Regulatory T cells and autoimmune disorders in Down syndrome

James Costello, PhD

Associate Professor, Pharmacology 

Cory Dunnick, MD

Associate Professor, Dermatology 

Joaquin Espinosa, PhD

Elena Hsieh, MD

Assistant Professor, Immunology and Microbiology

Understanding hyperactive interferon in trisomy 21 at the single-cell level​

Stephanie James, PhD

Assistant Professor, Pharmacy (Regis University)

Edward Janoff, MD

Professor, Medicine-Infectious Disease

Impact of trisomy 21 on B cell phenotype and function in adults​

Laurel Lenz, PhD

Professor, Immunology and Microbiology 

Mechanisms responsible for increased type I IFN responses in trisomy 21

Edwin Liu, MD

Professor, Pediatrics-Gastroenterology, Hepatology and Nutrition

Celiac disease signatures in Down syndrome

David Norris, MD

Professor, Dermatology

Safety and efficacy of tofacitinib for immune skin conditions in Down syndrome

Brian O’Connor, PhD

Associate Professor, Immunology and Microbiology

Chromatin regulation of adaptive immune dysfunction in Down syndrome

Richard Lee Reinhardt, PhD

Assistant Professor, Immunology and Microbiology

Mechanisms of reduced allergic susceptibility in Down syndrome

Jingshi Shen, PhD

Associate Professor, Molecular, Cellular, and Developmental Biology

Dysregulation of cytotoxic lymphocyte-mediated cell killing in trisomy 21

Richard Spritz, MD 

Professor, Human Medical Genetics

Genetic analysis of autoimmunity in Down syndrome​

Kelly Sullivan, PhD

Dylan Taatjes, PhD

Professor, Biochemistry

Mediator kinases as interferon antagonists in Down syndrome

Beth Tamburini, PhD

Assistant Professor of Medicine and Immunology

Impact of immune dysregulation on liver function in Down syndrome

Michael Verneris, MD

Professor of Pediatrics-Heme/Onc and Bone Marrow Transplantation

Innate immune dysregulation in tonsils of individuals with Down syndrome

Elizabeth Wallace, MD

Assistant Professor, Dermatology 

Eduardo DaVila, PhD

Professor of Medicine-Medical Oncology 

The immune system and development of cancer and leukemia in Down syndrome

James DeGregori, P​hD

Professor, Biochemistry and Molecular Genetics

Causes and conseq​uences of altered DNA repair in Down syndrome

Terry Fry, MD

Professor, Pediatrics-Heme/Onc and Bone Marrow Transplantation

The immune system and development of cancer and leukemia in Down syndrome

Jay ​Hesselberth, PhD

Associate Professor, Biochemistry and Molecular Genetics

Causes and consequences of altered DNA repair in Down syndrome

Craig Jordan, PhD

Professor, Medicine-Hematology 

The immune system and development of cancer and leukemia in Down syndrome

Kelly ​Maloney, MD

Professor, Pediatrics-Heme/Onc and Bone Marrow Transplantation

Novel non-toxic therapeutic strategies for leukemia in Down syndrome

Eric Pietras, PhD

Assistant Professor, Medicine-Hematology 

Interferons as a trigger of hematopoietic chemotoxicity following DS-ALL therapy​

Michael Verneris, MD

Professor of Pediatrics-Heme/Onc and Bone Marrow Transplantation

Chimeric antigen receptor T cells in Down syndrome

Rui Yi, PhD

Assistant Professor, Molecular, Cellular, and Developmental Biology

Mechanisms of miR-155 mediated leukemogenesis in trisomy 21

Steve Abman, MD

Professor, Pediatrics-Pulmonary and Sleep Medicine 

Cardiopulmonary diseases in Down syndrome

Kambez Benam, PhD

Assistant Professor, Medicine-Pulmonary Sciences and Criti​cal Care​

Lung-on-a-chip to model Down syndrome airway pathophysiology​

Ganna Bilousova, PhD

Assistant Professor, Dermatology

Exploring endothelial progenitor cell defects in Down syndrome​​​

Emily DeBoer, MD

Associate Professor of Pediatrics-Pulmonary Medicine

Identifying measures of pulmonary morbidity for clinical trials in aspiration

Rob Fuhlbrigge, MD, PhD

Professor of Pediatrics-Rheumatology

Csaba ​Galambos, MD, PhD

Associate Professor, Pathology 

Overexpression of anti-angiogenic genes impairs lung development in Dp16 mice​

Francis Hickey, MD

Medical Director of the Anna and John J. Sie Center for Down Syndrome

Jeffrey Jacot, PhD

Associate Professor, Bioengineering

Mechanotransduction pathways during heart development in Down syndrome

Mike Klymklowsky, PhD

Professor, Molecular, Cellular, and Developmental Biology

Inductive signaling in iPSC-derived trisomy 21 cerebral organoids

Niklaus Mueller, PhD

Assistant Research Professor, Ophthalmology

Malformation of the ocular lens in Down syndrome visual impairment​

Mark Petrash, PhD

Research Professor and Vice Chair of Research, Ophthalmology

Cellular and molecular basis of vision defects in Down syndrome​

Kunhua Song, PhD

Assistant Professor, Medicine-Cardiology

Cardiomyocytes and congenital heart defects in Down syndrome​

Maria Natalia Vergara, PhD

Assistant Professor, Ophthalmology

Michael Yeager, PhD

Clinical Associate Professor, Bioengineering

Lung immune environment and pneumonia infection in Down syndrome