We use state-of-the-art, transformational research platforms to decipher the unique biology and disease spectrum caused by trisomy of chromosome 21. 

Our ultimate goal is to enable precision medicine approaches to improve health outcomes in Down syndrome, including the development of new diagnostic and therapeutic tools.​​​

The Linda Crnic Institute logo is a dark blue circle encompassing three double helixes, representing the triplication of chromosome 21

JAK1 inhibitor kaplan meier plot

Crnic scientists show JAK1 inhibition normalizes damaging immune response in mouse model of Down syndrome

Databases and analyses

Crnic Institute plays leading role in NIH INCLUDE data coordinating center for Down syndrome research

Couple with Down syndrome wearing masks

US News & World Report interviews Dr. Espinosa on why people with Down syndrome face higher risk of severe COVID-19

Dr. Barry Martin listens with a stethoscope to a young man with Down syndrome

Global Down Syndrome Foundation publishes medical care guidelines for adults with Down syndrome in JAMA


We are the largest geographical cluster of Down syndrome researchers in the world​

Comprised of over 50 Principal Investigators and countless more contributing scientists from across the University of Colorado campuses, our researchers bring expertise from a variety of fields.

Together, we are working to decipher the complex mechanisms and multi-faceted health impacts of trisomy 21.

The Linda Crnic Institute logo is a dark blue circle encompassing three double helixes, representing the triplication of chromosome 21

Scientists in lab coats talking in the lab

We need partners like you to grow and accelerate our work

Ours is a mission that was never meant to be accomplished alone. We are grateful for our scientists, business partners, generous donors, and brave research volunteers, and we cannot continue moving forward without your sustained support.