We use state-of-the-art, transformational research platforms to decipher the unique biology and disease spectrum caused by trisomy of chromosome 21.
Our ultimate goal is to enable precision medicine approaches to improve health outcomes in Down syndrome, including the development of new diagnostic and therapeutic tools.
We are the largest geographical cluster of Down syndrome researchers in the world
Comprised of over 50 Principal Investigators and countless more contributing scientists from across the University of Colorado campuses, our researchers bring expertise from a variety of fields.
Together, we are working to decipher the complex mechanisms and multi-faceted health impacts of trisomy 21.
New Study Reveals Widespread Liver Dysfunction in Down Syndrome, Suggests Link to Diet
Crnic Institute findings published in Cell Reports highlight understudied abnormal liver function in people with Down syndrome and possible dietary interventions
Crnic Institute and INCLUDE DCC Launch New Experimental Models of Down Syndrome Portal
The Experimental Models Portal provides an integrated platform for finding, sharing, and analyzing datasets and biospecimens generated from animal and cellular models of Down syndrome.
NIH announces relaunch of DS-Connect®: The Down Syndrome Registry
Last year, DS-Connect temporarily paused operations as NIH made plans for a refresh, selecting the University of Colorado Denver as the registry’s new service provider.
Dr. Joaquin Espinosa featured in the Washington Post
Dr. Joaquin Espinosa, executive director of the Crnic Institute, discusses the devastating condition known as Down syndrome regression disorder (DSRD) and the exciting new clinical trial investigating potential treatments.
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Ours is a mission that was never meant to be
accomplished alone. We are grateful for our scientists, business partners, generous donors, and brave
research volunteers, and we cannot continue moving forward without your
sustained support.