Our mission is ambitious, yet simple: to significantly improve the lives of people with Down syndrome by understanding how trisomy 21 causes a different disease spectrum.

This project will significantly advance our understanding of several major medical conditions and human biology in general, enabling the development of novel diagnostic and therapeutic tools to serve not only individuals with Down syndrome, but also the billions worldwide who experience conditions affected by trisomy 21.

Any person with Down syndrome between the ages of six months to 89 years can participate in the HTP. We also welcome participants from past years to participate again!

Participation includes a successful blood draw, a mouth swab and allowing researchers to look at your health information. Compensation will be provided.

Check out a few of our groundbreaking discoveries from HTP data.

1. Multidimensional definition of the interferonopathy of Down syndrome and its response to JAK inhibition
2. Janus kinase inhibition in Down syndrome: 2 cases of therapeutic benefit for alopecia areata
3. Trisomy 21 consistently activates the interferon response