Grand Challenge Grants

The Grand Challenge Grant Program is designed for individual investigators at the University of Colorado and grants $50,000-increment awards in an ongoing milestone-based program.

Man standing on cliff looking over a valley


This Request for Applications (RFA) is issued by the Linda Crnic Institute for Down Syndrome to address major research questions, or "Grand Challenges​​," in Down syndrome and to assist investigators in obtaining independent funding for these projects. Grand Challenge Grant applications should propose defined research projects that will further our understanding of key Down syndrome phenotypes or co-morbidities and advance the mission and vision of the Crnic Institute, as well as the larger Down syndrome research community. Applications should also be responsive to the NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project. ​

Award Information

Awards are $50,000 and no indirect costs are provided. Limited salary support, fringe benefits, and teaching buy-out are permissible, but it is expected that the majority of the budget will be for direct research support, e.g. supplies, salaries for technicians, post-docs, graduate students, and necessary equipment.

Recipients can request additional funding of $50,000 as their project progresses. Requests for additional funding are evaluated in light of adherence to the stated Recipient Requirements and successful completion of project milestones, which would be defined and approved in collaboration with Crnic Institute leadership.​

Award Timeline

Funding of Successful Applicants Begins: April 2020​.​

As approved milestones are obtained, additional funding may be applied for in $50,000 increments.


Please contact​​.