Matthew Wortham PhD
Asst Professor
- Anschutz Campus - Sch of Med - BDC Basic Research
Email Address:matthew.wortham@cuanschutz.edu
Matthew Wortham, PhD
The Wortham lab studies how pancreatic beta cells sense and respond to changes in their environment in physiological conditions or pathological states related to diabetes. We focus on how extracellular signals interface with gene regulation by monitoring effects of changing cellular environments upon epigenomic modifications and metabolism in the beta cell. To conduct these studies we employ metabolomics, single cell genomics, and genetic or pharmacological manipulations in primary human tissue and in animal models of diabetes. The goal of our research is to understand how this regulatory system could be therapeutically targeted to forestall beta cell destruction in type 1 diabetes.