Jordan Jacobelli

The ability of lymphocytes to migrate and localize within the body is critical to the function of the immune system and also plays a role in disease settings such as autoimmunity. My laboratory is interested in understanding how a network of proteins called the cytoskeleton regulates the migration and cell-cell interactions of lymphocytes. In particular we focus on how cytoskeletal molecules, such as the Formin and Ena/Vasp proteins, generate the mechanical forces and shape changes required for lymphocyte migration during homeostasis and disease.