NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia

NUDT21 limits CD19 levels

Witkowski MT*, Lee S*, Wang E*, Lee AK, Talbot A, Ma C,  Tsopoulidis N, Brumbaugh J, Zhao Y, Roberts KG, Hogg SJ, Nomikou S, Ghebrechristos YE, Thandapani P, Mullighan CG,  Hochedlinger K, Chen W, Abdel-Wahab O, Eyquem J & Aifantis I.

Nature Immunology (2022)

Extensive Remodeling of the Immune Microenvironment in B-cell Acute Lymphoblastic Leukemia

Extensive Remodeling of the Immune Microenvironment

Witkowski MT*, Dolgalev I*, Evensen NA, Ma C, Chambers T, Roberts CG, Sreeram S, Dai Y, Tikhonova AN, Lasry A, Qu C, Pei D, Cheng C, Robbins GA, Pierro J, Selvaraj S, Mezzano V, Daves M, Lupo PJ, Scheurer ME, Loomis CA, Mullighan CG, Chen W, Rabin KR, Tsirigos A, Carroll WL & Aifantis I.

Cancer Cell (2020)

Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcome

Conserved IKAROS-regulated genes

Witkowski MT, Hu Y, Roberts KG, Boer JM, McKenzie MD, Liu GJ, Le Grice OD, Tremblay CS, Ghisi M, Willson TA, Horstmann MA, Aifantis I, Cimmino L, Frietze S, den Boer ML, Mullighan CG, Smyth GK, Dickins RA.

J Exp Med (2017)

Activated Notch Signaling counteracts Ikaros tumor suppression in mouse and human T cell acute lymphoblastic leukemia

Activated Notch Signaling

Witkowski MT*, Cimmino L*, Hu, Y, Trimarchi T, Tagoh H, McKenzie MD, Best SA, Tuohey L, Willson TA, Nutt SL, Busslinger M, Aifantis I, Smyth GK, Dickins RA.

Leukemia (2015)

Review Article: Single-cell analysis of acute lymphoblastic and lineage ambiguous leukemia – approaches and molecular insights

single-cell analysis

Iacobucci I, Witkowski MT, Mullighan CG

Blood (2022)

Review Article: Mapping and targeting of the leukemic microenvironment

Mapping and targeting of the leukemic microenvironment

Witkowski MT, Kousteni S, Aifantis I.

J Exp Med (2020)

Review Article: Immune-Based Therapies in Acute Leukemia

Immune-Based Therapies in Acute Leukemia

Witkowski MT*, Lasry A*, Carroll WL, Aifantis I.

Trends in Cancer (2019)

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