Research Projects
Current research trials are very important for helping to develop an understanding of how the human body works. Trials are also how we figure out new treatment options.
Our Current Studies:
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Role of Semaglutide in Restoring Ovulation in Youth and Adults with Polycystic Ovary Syndrome (RESTORE Study)
The purpose of the RESTORE study is to investigate the impact of semaglutide and metformin treatment on the ovulation of women and adolescent girls with PCOS. Our overarching hypothesis is that weight loss and metabolic improvements are required to improve reproductive health in individuals with PCOS.
Who are we looking for?
- Female sex
- Age 12-35 years old
- Diagnosis of PCOS based on irregular menses cycles (6 or more weeks between) and high testosterone levels or testosterone related skin findings
- Excess weight. BMI > 30 kg/m2 for adults and > 95th percentile if 18 years and under.
- Okay if you are taking Metformin
- Cannot have type 2 diabetes
- Cannot be taking any hormonal medication
- Must avoid becoming pregnant during the study
If you join the study, you will receive the following:
- 6 visits to our facility in Denver, Colorado over the course of 14 months
- PCOS specific dietary counseling for a year
- 10 months of medication with semaglutide
- Measurement of body composition
- Testing for diabetes
- PCOS education and support
- Measurement of ovulation frequency
- Reimbursement for time
See if you qualify!
Effect of Amino Acids on Hepatic Fat Content in Adolescents
We are currently recruiting for the AMINOS study. We need volunteers for fatty liver disease research. The purpose of the AMINOS study is to test if an amino acid drink can help reduce fat in the liver.
Who are we looking for?
- Patient at Children's Hospital Colorado
- Age 12-18 years old
- Diagnosis of metabolic associated steatosis liver disease based on a liver biopsy
- Excess weight: BMI > 95th percentile
- Cannot have type 2 diabetes
If you join the study, you will receive the following:
- 2 months of amino acid supplement drink or 2 months of placebo with option to receive additional 10 months of amino acid supplement drink
- Measurement of body composition including a liver MRI
- Testing for diabetes
- Reimbursement for time
Clinical Adolescent Polycystic Ovary (CALICO) Database
This is a multi-site database on patient characteristics and treatment response for adolescents with PCOS. We are currently adding sites from around the United States. There is a minimum commitment of 25 patients, with at least 1 diagnostic, and 2 follow-up clinical visits over more than one year. Opportunities for authorship, with data to be used for publications from the CALICO Consortium.
Interested in joining the project?
Learn more here!