Patient Education Resources
Clinicians using the UCHealth EHR can use dotphrase: .pgxvoriconazoletopatientVoriconazole Tip Sheet
The following information is intended for use by providers who are attempting to prescribe voriconazole to patients with certain CYP2C19 genetic variants.
For immediate questions, send a secure chat message to Groups: Pharmacogenomics Service in UCHealth's EHR.
References:
- https://cpicpgx.org/guidelines/guideline-for-voriconazole-and-cyp2c19/
- Miller MA, Lee YM. Applying Pharmacogenomics to Antifungal Selection and Dosing- Are We There Yet? Curr Fungal Infect Rep. 2020; 14(1): 63-75.
- Obeng AO, et al. CYP2C19 Polymorphisms and Therapeutic Drug Monitoring of Voriconazole: Are We Ready for Clinical Implementation of Pharmacogenomics? Pharmacotherapy. 2014; 34(7): 703-18.
- Lamoureux F, et al. Impact of CYP2C19 genetic polymorphisms on voriconazole dosing and exposure in adult patients with invasive fungal infections. Int J Antimicrob Agents. 2016; 47(2): 124-31.
- Hamadeh IS, et al. Impact of the CYP2C19 genotype on voriconazole exposure in adults with invasive fungal infections. Pharmacogenet Genomics. 2017; 27(5): 190-6.
Voriconazole and CYP2C19 Tip Sheet by Christina L. Aquilante is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Based on a work at https://medschool.cuanschutz.edu/cobiobank/providers/results/pgx/voriconazole-tipsheet.