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When you take a medicine (or a drug), your body needs to find a way to use it. Some proteins in your body break down (or metabolize) medicines. Breaking down a medicine can make it more or less active, based on the medicine. If you break down a medicine too fast or too slowly, this may cause the medicine to not work as well or it may cause a side effect.
Cytochrome P450 is a family of proteins that helps your body break down certain medicines. Cytochrome P450 family 2 subfamily C member 19 (CYP2C19) (say “SIP-2-see-19”) is one certain protein in this family. It is the job of CYP2C19 to break down some medicines we use.
By testing your DNA, we can find DNA differences that can help us to see how well your CYP2C19 protein may work in you. The results of this test can help your doctor choose a certain medicine or a certain dose of medicine that is right for you. The results of your CYP2C19 gene test will place you into one of 5 groups:
People in the group likely have normal working CYP2C19 proteins.
People in this group likely have very little or no active CYP2C19 proteins. People who are poor metabolizers may break down some medicines more slowly.
People in this group likely have reduced activity of CYP2C19 proteins. People who are intermediate metabolizers may break down some medicines at a rate in between the poor and normal metabolizers.
People in this group likely have high activity of CYP2C19 proteins. People who are rapid metabolizers may break down some medicines more quickly.
People in this group likely have very high activity of CYP2C19 proteins. People who are ultrarapid metabolizers may break down some medicines more quickly.
CYP2C19 proteins break down many medicines that are often used. These medicines include:
Clopidogrel - used to keep you from getting blood clots
Some selective serotonin reuptake inhibitors (SSRIs) - used for depression
Some proton pump inhibitors (PPIs) - used to treat stomach ulcers
Voriconazole - used for fungal infections
Clobazam and Brivaracetam - used for seizures
These are the medicines that we know of right now that are broken down by CYP2C19 proteins and affected by CYP2C19 gene test results. Experts keep on finding new data about which medicines are affected by gene test results.
The result of your CYP2C19 gene test will place you into 1 of 5 groups above (listed in overview). Knowing what group you are in may help your doctor to pick the right medicine and right dose for you. We encourage you to talk with your doctor about your CYP2C19 gene test result.
The information you receive through this website is not intended to be medical advice. The information you receive through this website will include genetic test results only. If you need medical assistance, please seek care at an appropriate facility. You should contact your doctor about any genetic test results that you receive from the Biobank. Do not stop using or change any of your medicines before speaking with your doctor.