Eligibility Criteria for ImTAB study



Please note that additional things may come up during the course of screening that impact enrollment eligibility, which is ultimately up to the discretion of the study team.

Inclusion Criteria

You may be eligible for this study if you:

  • Are between the ages 65 and 89
  • Have a reliable study partner who has frequent (i.e., at least twice per month) contact with the subject and is able to provide information about functional abilities
  • Are in range on the brief cognitive screening exam
  • Have no informant report of significant cognitive decline in prior year
  • Have no evidence from the screening visit suggesting a neurodegenerative disorder (per team neurologist, fellow, or medical staff clinical judgment)
  • Are willing to return for a 1-year follow-up research appointment
  • Sustained concussion within past 5 years but not within past 5 months
  • Have confirmation of event and severity by Emergency Department, Urgent Care, or physician/primary care physician (PCP) within 1 week of event

Exclusion Criteria

You may not be eligible for this study if:

  • Major Psychiatric disorder (e.g. schizophrenia; bipolar disorder; major depression
    within past year**)
  • Neurological conditions affecting cognition (Parkinson’s disease; epilepsy; large
    vessel infarct; multiple sclerosis)
  • Current systemic medical illnesses (e.g., cancer, renal failure; exception of stable
    prostate cancer)
  • Substance abuse/dependence within past 5 years
  • Current medications likely to affect central nervous system functions (e.g., long-acting benzodiazepines)
  • Significant sensory or motor deficits that would interfere with cognitive testing
  • Factors that preclude MR imaging
  • Other medical, cognitive, psychiatric, or lifestyle issues that may, in the judgement of the investigator, impede the successful fulfillment of study requirements

**prospective participants who previously received a diagnosis of major depression in the past 2 years, but are actively being treated with an anti-depressant and are not reporting significant mood symptoms at study entry may still be considered for enrollment.

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