Eligibility Criteria for ImTAB study

Inclusion Criteria

You may be eligible for this study if you:

• Are between the ages 65 and 89
• Have a reliable study partner who has frequent (i.e., at least twice per month) contact with the subject and is able to provide information about functional abilities
• Are in range on the brief cognitive screening exam
• Have no informant report of significant cognitive decline in prior year
• Have no evidence from the screening visit suggesting a neurodegenerative disorder (per team neurologist, fellow, or medical staff clinical judgment)
• Are willing to return for a 1-year follow-up research appointment
• Sustained concussion within past 5 years but not within past 5 months
• Have confirmation of event and severity by Emergency Department, Urgent Care, or physician/primary care physician (PCP) within 1 week of event

Exclusion Criteria

You may not be eligible for this study if:

• Major Psychiatric disorder (e.g. schizophrenia; bipolar disorder; major depression
  within past year**)
• Neurological conditions affecting cognition (Parkinson’s disease; epilepsy; large
  vessel infarct; multiple sclerosis)
• Current systemic medical illnesses (e.g., cancer, renal failure; exception of stable
  prostate cancer)
• Substance abuse/dependence within past 5 years
• Current medications likely to affect central nervous system functions (e.g., long-acting benzodiazepines)
• Significant sensory or motor deficits that would interfere with cognitive testing
• Factors that preclude MR imaging
• Other medical, cognitive, psychiatric, or lifestyle issues that may, in the judgement of the investigator, impede the successful fulfillment of study requirements

**prospective participants who previously received a diagnosis of major depression in the past 2 years, but are actively being treated with an anti-depressant and are not reporting significant mood symptoms at study entry may still be considered for enrollment.