Recent PRC Faculty Publications
January-June 2026
Maternal Western-style Diet Promotes Immune Tolerance and Liver Sinusoidal Endothelial Cell Dysfunction in Nonhuman Primate Juvenile Offspring Liver.
Nash MJ, Nelson BN, McGuckin M, Janssen RC, Jones KL, Al-Juboori SI, Dobrinskikh E, Kievit P, Aagaard KM, McCurdy CE, Gannon M, Wesolowski SR, Friedman JE.bioRxiv [Preprint]. 2026 Jan 7:2026.01.06.697995. doi: 10.64898/2026.01.06.697995.PMID: 41542443 Free PMC article.
In vivo physiological ramifications of placental SLC2A3-RNA interference throughout gestation in sheep.
Kennedy VC, Tanner AR, Lynch CS, Winger QA, Rozance PJ, Anthony RV.J Anim Sci. 2026 Jan 8;104:skag118. doi: 10.1093/jas/skag118.PMID: 41968075 Free PMC article.
Acetaminophen and pregnancy: common exposure, potential placental impact.
Etuka BS, Eason CR, Golden EM, Derderian SC, Wright CJ.J Anim Sci. 2026 Jan 8;104:skag209. doi: 10.1093/jas/skag209.PMID: 42489539 Free PMC article.
Investigating trophoblast invasion and angiogenesis expression changes in a caloric deficient mouse model of fetal growth restriction.
Bardill JR, Eason CR, Wood H, Breckenfelder C, Gallagher LT, Crew M, Karimpour-Fard A, Sucharov CC, Powell TL, Wright CJ, Derderian SC.Reprod Biol. 2026 Jun;26(2):101179. doi: 10.1016/j.repbio.2026.101179. Epub 2026 Jan 22.PMID: 41576455
Delayed administration of type II ampakines enhance synaptic plasticity and cognitive recovery in juvenile global cerebral ischemia.
Henry JE, Fineberg AA, McVey TB, Tiemeier EL, Orfila JE, Herson PS, Dietz RM.J Cereb Blood Flow Metab. 2026 Jun;46(6):1681-1692. doi: 10.1177/0271678X251405662. Epub 2026 Jan 29.PMID: 41612671
Trophoblast-specific overexpression of Slc7a5 increases fetal amino acid availability and hepatic mTOR signalling and causes increased fetal growth.
Rosario FJ, Shimada H, Fredrick SBJ, Barentsen K, Powell TL, Urschitz J, Brown TL, Brown L, Jansson T.J Physiol. 2026 Mar;604(5):2276-2301. doi: 10.1113/JP289970. Epub 2026 Jan 31.PMID: 41618849
Oxygen and glucose supplementation increases rates of linear growth and cell proliferation in growth-restricted fetal sheep.
Varela M, Chrisenberry DB, Johnson EH, Luna-Ramirez RI, Tracy AR, Kathuria S, Zhao W, Anderson MJ, Brown LD, Limesand SW.J Physiol. 2026 Apr;604(7):2778-2795. doi: 10.1113/JP290141. Epub 2026 Mar 16.PMID: 41840346 Free PMC article.
Development of striated muscle microvasculature across the perinatal period in lambs.
Chang EI, Al-Juboori SI, Dear TB, Varanasi S, Painter CS, Stacey HE, Saunders EF, Stremming J, Louey S, Strode D, Dobrinskikh E, Jonker SS, Brown LD.J Physiol. 2026 Apr;604(8):3476-3493. doi: 10.1113/JP290159. Epub 2026 Mar 21.PMID: 41863537 Free PMC article.
Novel neonatal hypoxic-ischemic model demonstrates neuroinflammation-associated memory deficits without neuronal loss.
Langer KM, Tiemeier E, Harmon E, Fineberg A, Henry J, Veitch I, Klopper T, McVey T, Dietz RM, Dingman AL, Quillinan N.bioRxiv [Preprint]. 2026 Mar 23:2026.03.19.712953. doi: 10.64898/2026.03.19.712953.Update in: Pediatr Res. 2026 Aug 3. doi: 10.1038/s41390-026-05281-0.PMID: 41929203 Free PMC article.
Experimental chronic fetal hyperglucagonemia stimulates hepatic pathways for amino acid catabolism and gluconeogenesis.
Tanner AR, Cilvik SN, Nguyen MA, Brown LD, Anthony RV, Wright CJ, Wesolowski SR, Rozance PJ.J Endocrinol. 2026 Apr 28;269(1):e250447. doi: 10.1530/JOE-25-0447. Print 2026 Apr 1.PMID: 41988876 Free PMC article.
Elevated catecholamine derivatives homovanillic acid and vanillylmandelic acid in the plasma and amniotic fluid of growth-restricted fetal sheep.
Moutwakil A, White A, Wesolowski SR, Brown LD, Rozance PJ.Pediatr Res. 2026 Apr 18. doi: 10.1038/s41390-026-04957-x. Online ahead of print.PMID: 42000896
R213G-Mediated Redistribution of EC-SOD Protects Against Sugen-Hypoxia Pulmonary Hypertension in Mice.
Colon Hidalgo D, Lewis CV, Nguyen TN, Posey JN, Burciaga SD, Dee N, Sul C, Harral J, Irwin D, Delaney C, Nozik ES.Pulm Circ. 2026 Apr 24;16(2):e70307. doi: 10.1002/pul2.70307. eCollection 2026 Jun.PMID: 42039680 Free PMC article.
Correction of hypoxemia and hypoglycemia restores muscle mitochondrial respiration and remodels mitochondrial proteome in growth-restricted sheep fetuses.
Zhao W, Chrisenberry DB, Varela M, Luna-Ramirez RI, Anderson MJ, Langlais PR, Brown LD, Limesand SW.Am J Physiol Endocrinol Metab. 2026 Jun 1;330(6):E774-E781. doi: 10.1152/ajpendo.00073.2026. Epub 2026 Apr 30.PMID: 42059806 Free PMC article.
Ectopic expression of MUC5B in the respiratory bronchiole initiates endoplasmic reticulum stress in the IPF lung.
Blumhagen RZ, Kurche JS, Cool CD, Heinz D, Ma X, Davidson EJ, Fingerlin TE, Huber JP, Dobrinskikh E, Schwartz DA, Yang IV.Am J Respir Cell Mol Biol. 2026 May 1;74(5):632-643. doi: 10.1165/rcmb.2025-0261OC.PMID: 41091081 Free PMC article.
Genes, other than Muc5b, are associated with bleomycin-induced lung injury.
Wang Y, Hennessy C, Dobrinskikh E, Humphries SM, Hatakka K, Ackert-Bicknell CL, Godfrey DA, Kelada SNP, Keele GR, Cardwell J, Peljto A, Clouthier DE, Yang IV, Schwartz DA.Commun Biol. 2026 May 12;9(1):1006. doi: 10.1038/s42003-026-10239-3.PMID: 42120750 Free PMC article.
TLR9-mediated innate immune signaling contributes to acetaminophen-induced injury in the developing lung.
Malyshkina A, Solar M, Balasubramaniyan N, Zheng L, McCulley DJ, Morro M, Seymour C, Sajti E, Orlicky DJ, Sosa A, Smith BJ, Wright CJ. Am J Physiol Lung Cell Mol Physiol. 2026 Jul 1;331(1):L16-L33. doi: 10.1152/ajplung.00085.2026. Epub 2026 May 19.PMID: 42155595 Free PMC article.
Interferon receptor gene dosage differentially regulates hypoxia-induced platelet activation and pulmonary hypertension in down syndrome.
Posey JN, Jordan M, Olsen-Dufour A, Nguyen TN, Farrell C, Lewis CV, Archambault JL, Sul C, Colon-Hidalgo D, Nozik ES, Espinosa JM, Sullivan KD, Delaney C.Front Immunol. 2026 May 22;17:1832057. doi: 10.3389/fimmu.2026.1832057. eCollection 2026.PMID: 42253980 Free PMC article.
Priming innate immunity and long-term outcome.
Pradler V, Wright CJ, Kazemi-Butterfield N, Glaser K.Mol Cell Pediatr. 2026 May 27;13(1):31. doi: 10.1186/s40348-026-00244-1.PMID: 42192061 Free PMC article.
Fatty acid-binding protein 5 deficiency impairs alveolar macrophage function and metabolism.
Ratliff JH, Aviszus K, Addi S, El Kharbili M, Fujaros S, Sasse SK, Vestal BE, Gerber AN, Dobrinskikh E, Gally F.J Lipid Res. 2026 Jul;67(7):101069. doi: 10.1016/j.jlr.2026.101069. Epub 2026 Jun 23.PMID: 42335653 Free PMC article.
July-December 2025
Placental insufficiency disrupts cardiomyocyte ploidy and cell cycle fate in growth-restricted fetal sheep.
Barooni N, Hetrick B, Brown LD, McCurdy CE, Chang EI.
Am J Physiol Regul Integr Comp Physiol. 2026 Jan 1;330(1):R60-R71. doi: 10.1152/ajpregu.00233.2025. Epub 2025 Dec 11. PMID:41379574 Free PMC article.
Slow-twitch oxidative myofiber proportions and capillary number per myofiber are reduced in growth-restricted fetal sheep.
Dear TB, Chang EI, Al-Juboori SI, Stremming J, Wesolowski SR, Jonker SS, Rozance PJ, Dobrinskikh E, Brown LD.
Am J Physiol Regul Integr Comp Physiol. 2025 Dec 1;329(6):R907-R919. doi: 10.1152/ajpregu.00044.2025. Epub 2025 Oct 21. PMID:41117441 Free PMC article.
Fetal programming under maternal heat stress: a focus on skeletal muscle growth and nutrition in livestock.
Zhao W, Luna Ramirez RI, Rhoads RP, Brown LD, Limesand SW.
J Dev Orig Health Dis. 2025 Aug 1;16:e28. doi: 10.1017/S2040174425100111. PMID:40746297Free PMC article.Review.
Revealing gait as a murine biomarker of injury, disease, and age with multivariate statistics and machine learning.
Naved BA, Han S, Koss KM, Kando MJ, Wang JJ, Chang J, Weiss C, Passman MG, Wertheim JA, Luo Y, Zhang ZJ.
Sci Rep. 2025 Sep 29;15(1):33457. doi: 10.1038/s41598-025-02073-0. PMID:41022923 Free PMC article.
Metabolic Reprogramming of Oligodendrocytes in Intrauterine Growth Restriction.
Peters H, Fung CM, Dettman RW, Dizon MLV, Chang J.
Dev Neurosci. 2025 Sep 15:1-19. doi: 10.1159/000548455. Online ahead of print. PMID:40952938 Free PMC article.
Platelet-Macrophage Aggregates in Remodeled Vessels of Patients With Pulmonary Arterial Hypertension.
Farrell CL, Jordan M, Posey JN, Jordan KR, Gandjeva A, Nozik ES, Stenmark KR, Tuder RM, Graham BB, Delaney CA.
Pulm Circ. 2025 Oct 14;15(4):e70174. doi: 10.1002/pul2.70174. eCollection 2025 Oct. PMID:41104024 Free PMC article.
Delayed Fluoxetine Administration Restores Hippocampal Function in a Juvenile Global Cerebral Ischemia Mouse Model in a Sex-Specific Manner.
Fineberg A, McVey T, Henry J, Tiemeyer E, Orfila JE, Dietz RM.
Neural Plast. 2025 Dec 19;2025:8841616. doi: 10.1155/np/8841616. eCollection 2025. PMID:41497411 Free PMC article.
Ectopic Expression ofMUC5Bin the Respiratory Bronchiole Initiates Endoplasmic Reticulum Stress in the IPF Lung.
Blumhagen RZ, Kurche JS, Cool CD, Heinz D, Ma X, Davidson EJ, Fingerlin TE, Huber JP, Dobrinskikh E, Schwartz DA, Yang IV.
Am J Respir Cell Mol Biol. 2025 Oct 15:10.1165/rcmb.2025-0261OC. doi: 10.1165/rcmb.2025-0261OC. Online ahead of print. PMID:41091081 Free PMC article.
Fetal nutrient flux and oxidative metabolism during hypoxia: adaptive responses to defend fetal growth.
Kyllo HM, Wesolowski SR.
Philos Trans R Soc Lond B Biol Sci. 2025 Aug 21;380(1933):20240176. doi: 10.1098/rstb.2024.0176. Epub 2025 Aug 21. PMID:40836805 Free PMC article.
AMPK: Accumulating Evidence in Support of its role in Dual Regulation of Vascular Function and Metabolism During Human Pregnancy.
Moore LG, Wesolowski SR, Lorca RA, Julian CG.
Acta Physiol (Oxf). 2025 Sep;241(9):e70093. doi: 10.1111/apha.70093. PMID:40827403 Free PMC article. Review.
Maternal Western-style diet has a persistent effect on offspring gene expression in skeletal muscle of Japanese macaques.
Beck EA, Hetrick B, Nassar L, Turnbull DW, Dean TA, Takahashi DL, Gannon M, Wesolowski SR, Aagaard KM, Friedman JE, Kievit P, McCurdy CE.
Sci Rep. 2025 Jul 1;15(1):21324. doi: 10.1038/s41598-025-00828-3. PMID:40594058 Free PMC article.
Developmentally Regulated CYP2E1 Expression Is Associated with a Fetal Pulmonary Transcriptional Response to Maternal Acetaminophen Exposure.
Golden EM, Li Z, Zheng L, Solar M, Grayck MR, Talaba N, McCulley DJ, Orlicky DJ, Wright CJ.
Biomedicines. 2025 Oct 8;13(10):2446. doi: 10.3390/biomedicines13102446. PMID:41153729 Free PMC article.
January-June 2025
Endogenous recovery of hippocampal function following global cerebral ischemia in juvenile female mice is influenced by neuroinflammation and circulating sex hormones.
Vigil JJ, Tiemeier E, Orfila JE, Chalmers NE, Chang VN, Mitchell D, Veitch I, Falk M, Dietz RM, Herson PS, Quillinan N.
bioRxiv [Preprint]. 2025 Jan 31:2025.01.28.635301. doi: 10.1101/2025.01.28.635301.Update in: Neural Plast. 2025 May 9;2025:6103242. doi: 10.1155/np/6103242.PMID: 39975306 Free PMC article. Preprint.
A maternal hypoxia mouse model to study the effect of late gestational hypoxia on offspring lung outcomes.
Nguyen TN, Lewis CV, Hidalgo DC, Posey JN, Jordan M, Porfilio TE, Grayck MR, Wright CJ, Delaney C, Nozik ES
.Front Physiol. 2025 Feb 27;16:1513703. doi: 10.3389/fphys.2025.1513703. eCollection 2025.PMID: 40084179 Free PMC article.
Corrigendum to "Relationship Between Urine Serotonin and Persistent Pulmonary Hypertension of the Newborn". J Pediatr 2025; 276:114290.
Archambault JL, Hernandez TL, Nozik ES, Palmer C, Dillon M, Singh RJ, Galambos C, Delaney CA.
J Pediatr. 2025 Apr;279:114462. doi: 10.1016/j.jpeds.2025.114462. Epub 2025 Feb 8.PMID: 39924398 No abstract available.
A Two-Hour Fetal Glucagon Infusion Stimulates Hepatic Catabolism of Amino Acids in Fetal Sheep.
Tanner AR, Cilvik SN, Nguyen MA, Dobrinskikh E, Anthony RV, Wesolowski SR, Rozance PJ.
Int J Mol Sci. 2025 Feb 22;26(5):1904. doi: 10.3390/ijms26051904.PMID: 40076531 Free PMC article.
Maternal Western Diet Programmes Bile Acid Dysregulation and Hepatic Fibrosis in Fetal and Juvenile Macaques.
Nash MJ, Dobrinskikh E, Al-Juboori SI, Janssen RC, Fernandes J, Argabright A, D'Alessandro A, Kirigiti MA, Kievit P, Aagaard KM, McCurdy CE, Gannon M, Jones KL, Li T, Friedman JE, Wesolowski SR.
Liver Int. 2025 Feb;45(2):e16236. doi: 10.1111/liv.16236.PMID: 39865409 Free PMC article.
Nbeal2 knockout mice are not protected against hypoxia-induced pulmonary vascular remodeling and pulmonary hypertension.
Posey JN, Jordan M, Lewis CV, Sul C, Dobrinskikh E, Swindle D, Denorme F, Irwin D, Di Paola J, Stenmark K, Nozik ES, Delaney C.
Blood Adv. 2025 Apr 8;9(7):1571-1584. doi: 10.1182/bloodadvances.2024013880.PMID: 39693512 Free PMC article.
EBNEO Commentary: Is Therapeutic Hypothermia Beneficial to Infants Born Between 33 and 35 Weeks Gestation?
Spahic H, Zoubovsky SP, Dietz RM.
Acta Paediatr. 2025 Jul;114(7):1742-1743. doi: 10.1111/apa.70098. Epub 2025 Apr 18.PMID: 40251839 No abstract available.
A novel peptide inhibitor of TRPM2 channels improves recovery of memory function following traumatic brain injury.
Orfila JE, Dietz RM, Schroeder C, Patsos OP, Burch A, Bahamonde KE, Coakley KA, Carter DJ, Clevenger AC, Hendry-Hofer TB, Le TD, Maddry JK, Schauer SG, Bebarta VS, Herson PS.
Front Synaptic Neurosci. 2025 Apr 25;17:1534379. doi: 10.3389/fnsyn.2025.1534379. eCollection 2025.PMID: 40352737 Free PMC article.
Vascular EC-SOD limits the accumulation, proinflammatory profibrotic reprogramming, and hyaluronan binding of interstitial macrophages in hypoxia.
Lewis CV, Nguyen TN, Porfilio TE, Burciaga SD, Posey JN, Jordan M, Colon Hidalgo D, Stenmark KR, Mickael C, Sul C, Oberley-Deegan RE, Delaney C, Nozik ES.
Am J Physiol Lung Cell Mol Physiol. 2025 Jun 1;328(6):L885-L900. doi: 10.1152/ajplung.00399.2024. Epub 2025 May 7.PMID: 40332405 Free article.
Hypoxic pregnancy promotes fibrosis and increases stress metabolites in the ovine fetal liver.
McGuckin MM, Wang D, Ortiz J, Dobrinskikh E, Tong W, Botting-Lawford KJ, Niu Y, Giussani DA, Wesolowski SR.
J Physiol. 2025 May;603(10):3223-3243. doi: 10.1113/JP288724. Epub 2025 May 5.PMID: 40320974 Free PMC article.
Increased Circulating Extracellular Superoxide Dismutase Attenuates Platelet-Neutrophil Interactions.
Sul C, Lewis CV, Posey J, Jordan M, Colon Hidalgo D, Porfilio T, Elajaili H, McCormack G, Burciaga S, Delaney C, Nozik ES.
Am J Respir Cell Mol Biol. 2025 Jun;72(6):653-662. doi: 10.1165/rcmb.2024-0292OC.PMID: 39531632
NIH-funded neonatologist physician-scientists: an exploration of equity and success.
Horowitz EN, Good M, Machut KZ, Ahmad K, Wright CJ, Lingappan K.
Pediatr Res. 2025 Jun 30. doi: 10.1038/s41390-025-04224-5. Online ahead of print.PMID: 40588553
