Recent PRC Faculty Publications

July-December 2025

Placental insufficiency disrupts cardiomyocyte ploidy and cell cycle fate in growth-restricted fetal sheep.
Barooni N, Hetrick B, Brown LD, McCurdy CE, Chang EI.
Am J Physiol Regul Integr Comp Physiol. 2026 Jan 1;330(1):R60-R71. doi: 10.1152/ajpregu.00233.2025. Epub 2025 Dec 11. PMID:41379574 Free PMC article.

Slow-twitch oxidative myofiber proportions and capillary number per myofiber are reduced in growth-restricted fetal sheep.
Dear TB, Chang EI, Al-Juboori SI, Stremming J, Wesolowski SR, Jonker SS, Rozance PJ, Dobrinskikh E, Brown LD.
Am J Physiol Regul Integr Comp Physiol. 2025 Dec 1;329(6):R907-R919. doi: 10.1152/ajpregu.00044.2025. Epub 2025 Oct 21. PMID:41117441 Free PMC article.

Fetal programming under maternal heat stress: a focus on skeletal muscle growth and nutrition in livestock.
Zhao W, Luna Ramirez RI, Rhoads RP, Brown LD, Limesand SW.
J Dev Orig Health Dis. 2025 Aug 1;16:e28. doi: 10.1017/S2040174425100111. PMID:40746297Free PMC article.Review.

Revealing gait as a murine biomarker of injury, disease, and age with multivariate statistics and machine learning.
Naved BA, Han S, Koss KM, Kando MJ, Wang JJ, Chang J, Weiss C, Passman MG, Wertheim JA, Luo Y, Zhang ZJ.
Sci Rep. 2025 Sep 29;15(1):33457. doi: 10.1038/s41598-025-02073-0. PMID:41022923 Free PMC article.

Metabolic Reprogramming of Oligodendrocytes in Intrauterine Growth Restriction.
Peters H, Fung CM, Dettman RW, Dizon MLV, Chang J.
Dev Neurosci. 2025 Sep 15:1-19. doi: 10.1159/000548455. Online ahead of print. PMID:40952938 Free PMC article.

Platelet-Macrophage Aggregates in Remodeled Vessels of Patients With Pulmonary Arterial Hypertension.
Farrell CL, Jordan M, Posey JN, Jordan KR, Gandjeva A, Nozik ES, Stenmark KR, Tuder RM, Graham BB, Delaney CA.
Pulm Circ. 2025 Oct 14;15(4):e70174. doi: 10.1002/pul2.70174. eCollection 2025 Oct. PMID:41104024 Free PMC article.

Delayed Fluoxetine Administration Restores Hippocampal Function in a Juvenile Global Cerebral Ischemia Mouse Model in a Sex-Specific Manner.
Fineberg A, McVey T, Henry J, Tiemeyer E, Orfila JE, Dietz RM.
Neural Plast. 2025 Dec 19;2025:8841616. doi: 10.1155/np/8841616. eCollection 2025. PMID:41497411 Free PMC article.

Ectopic Expression ofMUC5Bin the Respiratory Bronchiole Initiates Endoplasmic Reticulum Stress in the IPF Lung.
Blumhagen RZ, Kurche JS, Cool CD, Heinz D, Ma X, Davidson EJ, Fingerlin TE, Huber JP, Dobrinskikh E, Schwartz DA, Yang IV.
Am J Respir Cell Mol Biol. 2025 Oct 15:10.1165/rcmb.2025-0261OC. doi: 10.1165/rcmb.2025-0261OC. Online ahead of print. PMID:41091081 Free PMC article.

Fetal nutrient flux and oxidative metabolism during hypoxia: adaptive responses to defend fetal growth.
Kyllo HM, Wesolowski SR.
Philos Trans R Soc Lond B Biol Sci. 2025 Aug 21;380(1933):20240176. doi: 10.1098/rstb.2024.0176. Epub 2025 Aug 21. PMID:40836805 Free PMC article.

AMPK: Accumulating Evidence in Support of its role in Dual Regulation of Vascular Function and Metabolism During Human Pregnancy.
Moore LG, Wesolowski SR, Lorca RA, Julian CG.
Acta Physiol (Oxf). 2025 Sep;241(9):e70093. doi: 10.1111/apha.70093. PMID:40827403 Free PMC article. Review.

Maternal Western-style diet has a persistent effect on offspring gene expression in skeletal muscle of Japanese macaques.
Beck EA, Hetrick B, Nassar L, Turnbull DW, Dean TA, Takahashi DL, Gannon M, Wesolowski SR, Aagaard KM, Friedman JE, Kievit P, McCurdy CE.
Sci Rep. 2025 Jul 1;15(1):21324. doi: 10.1038/s41598-025-00828-3. PMID:40594058 Free PMC article.

Developmentally Regulated CYP2E1 Expression Is Associated with a Fetal Pulmonary Transcriptional Response to Maternal Acetaminophen Exposure.
Golden EM, Li Z, Zheng L, Solar M, Grayck MR, Talaba N, McCulley DJ, Orlicky DJ, Wright CJ.
Biomedicines. 2025 Oct 8;13(10):2446. doi: 10.3390/biomedicines13102446. PMID:41153729 Free PMC article.

January-June 2025

Endogenous recovery of hippocampal function following global cerebral ischemia in juvenile female mice is influenced by neuroinflammation and circulating sex hormones.
Vigil JJ, Tiemeier E, Orfila JE, Chalmers NE, Chang VN, Mitchell D, Veitch I, Falk M, Dietz RM, Herson PS, Quillinan N. bioRxiv [Preprint]. 2025 Jan 31:2025.01.28.635301. doi: 10.1101/2025.01.28.635301.Update in: Neural Plast. 2025 May 9;2025:6103242. doi: 10.1155/np/6103242.PMID: 39975306 Free PMC article. Preprint.

A maternal hypoxia mouse model to study the effect of late gestational hypoxia on offspring lung outcomes.
Nguyen TN, Lewis CV, Hidalgo DC, Posey JN, Jordan M, Porfilio TE, Grayck MR, Wright CJ, Delaney C, Nozik ES .Front Physiol. 2025 Feb 27;16:1513703. doi: 10.3389/fphys.2025.1513703. eCollection 2025.PMID: 40084179 Free PMC article.

Corrigendum to "Relationship Between Urine Serotonin and Persistent Pulmonary Hypertension of the Newborn". J Pediatr 2025; 276:114290.
Archambault JL, Hernandez TL, Nozik ES, Palmer C, Dillon M, Singh RJ, Galambos C, Delaney CA.
J Pediatr. 2025 Apr;279:114462. doi: 10.1016/j.jpeds.2025.114462. Epub 2025 Feb 8.PMID: 39924398 No abstract available.

A Two-Hour Fetal Glucagon Infusion Stimulates Hepatic Catabolism of Amino Acids in Fetal Sheep.
Tanner AR, Cilvik SN, Nguyen MA, Dobrinskikh E, Anthony RV, Wesolowski SR, Rozance PJ.
Int J Mol Sci. 2025 Feb 22;26(5):1904. doi: 10.3390/ijms26051904.PMID: 40076531 Free PMC article.

Maternal Western Diet Programmes Bile Acid Dysregulation and Hepatic Fibrosis in Fetal and Juvenile Macaques.
Nash MJ, Dobrinskikh E, Al-Juboori SI, Janssen RC, Fernandes J, Argabright A, D'Alessandro A, Kirigiti MA, Kievit P, Aagaard KM, McCurdy CE, Gannon M, Jones KL, Li T, Friedman JE, Wesolowski SR.
Liver Int. 2025 Feb;45(2):e16236. doi: 10.1111/liv.16236.PMID: 39865409 Free PMC article.

Nbeal2 knockout mice are not protected against hypoxia-induced pulmonary vascular remodeling and pulmonary hypertension.
Posey JN, Jordan M, Lewis CV, Sul C, Dobrinskikh E, Swindle D, Denorme F, Irwin D, Di Paola J, Stenmark K, Nozik ES, Delaney C.
Blood Adv. 2025 Apr 8;9(7):1571-1584. doi: 10.1182/bloodadvances.2024013880.PMID: 39693512 Free PMC article.

EBNEO Commentary: Is Therapeutic Hypothermia Beneficial to Infants Born Between 33 and 35 Weeks Gestation?
Spahic H, Zoubovsky SP, Dietz RM.
Acta Paediatr. 2025 Jul;114(7):1742-1743. doi: 10.1111/apa.70098. Epub 2025 Apr 18.PMID: 40251839 No abstract available.

A novel peptide inhibitor of TRPM2 channels improves recovery of memory function following traumatic brain injury.
Orfila JE, Dietz RM, Schroeder C, Patsos OP, Burch A, Bahamonde KE, Coakley KA, Carter DJ, Clevenger AC, Hendry-Hofer TB, Le TD, Maddry JK, Schauer SG, Bebarta VS, Herson PS.
Front Synaptic Neurosci. 2025 Apr 25;17:1534379. doi: 10.3389/fnsyn.2025.1534379. eCollection 2025.PMID: 40352737 Free PMC article.

Vascular EC-SOD limits the accumulation, proinflammatory profibrotic reprogramming, and hyaluronan binding of interstitial macrophages in hypoxia.
Lewis CV, Nguyen TN, Porfilio TE, Burciaga SD, Posey JN, Jordan M, Colon Hidalgo D, Stenmark KR, Mickael C, Sul C, Oberley-Deegan RE, Delaney C, Nozik ES.
Am J Physiol Lung Cell Mol Physiol. 2025 Jun 1;328(6):L885-L900. doi: 10.1152/ajplung.00399.2024. Epub 2025 May 7.PMID: 40332405 Free article.

Hypoxic pregnancy promotes fibrosis and increases stress metabolites in the ovine fetal liver.
McGuckin MM, Wang D, Ortiz J, Dobrinskikh E, Tong W, Botting-Lawford KJ, Niu Y, Giussani DA, Wesolowski SR.
J Physiol. 2025 May;603(10):3223-3243. doi: 10.1113/JP288724. Epub 2025 May 5.PMID: 40320974 Free PMC article.

Increased Circulating Extracellular Superoxide Dismutase Attenuates Platelet-Neutrophil Interactions.
Sul C, Lewis CV, Posey J, Jordan M, Colon Hidalgo D, Porfilio T, Elajaili H, McCormack G, Burciaga S, Delaney C, Nozik ES.
Am J Respir Cell Mol Biol. 2025 Jun;72(6):653-662. doi: 10.1165/rcmb.2024-0292OC.PMID: 39531632

NIH-funded neonatologist physician-scientists: an exploration of equity and success.
Horowitz EN, Good M, Machut KZ, Ahmad K, Wright CJ, Lingappan K.
Pediatr Res. 2025 Jun 30. doi: 10.1038/s41390-025-04224-5. Online ahead of print.PMID: 40588553