Recent PRC Faculty Publications

January-June 2025

Endogenous recovery of hippocampal function following global cerebral ischemia in juvenile female mice is influenced by neuroinflammation and circulating sex hormones.
Vigil JJ, Tiemeier E, Orfila JE, Chalmers NE, Chang VN, Mitchell D, Veitch I, Falk M, Dietz RM, Herson PS, Quillinan N. bioRxiv [Preprint]. 2025 Jan 31:2025.01.28.635301. doi: 10.1101/2025.01.28.635301.Update in: Neural Plast. 2025 May 9;2025:6103242. doi: 10.1155/np/6103242.PMID: 39975306 Free PMC article. Preprint.

A maternal hypoxia mouse model to study the effect of late gestational hypoxia on offspring lung outcomes.
Nguyen TN, Lewis CV, Hidalgo DC, Posey JN, Jordan M, Porfilio TE, Grayck MR, Wright CJ, Delaney C, Nozik ES .Front Physiol. 2025 Feb 27;16:1513703. doi: 10.3389/fphys.2025.1513703. eCollection 2025.PMID: 40084179 Free PMC article.

Corrigendum to "Relationship Between Urine Serotonin and Persistent Pulmonary Hypertension of the Newborn". J Pediatr 2025; 276:114290.
Archambault JL, Hernandez TL, Nozik ES, Palmer C, Dillon M, Singh RJ, Galambos C, Delaney CA.
J Pediatr. 2025 Apr;279:114462. doi: 10.1016/j.jpeds.2025.114462. Epub 2025 Feb 8.PMID: 39924398 No abstract available.

A Two-Hour Fetal Glucagon Infusion Stimulates Hepatic Catabolism of Amino Acids in Fetal Sheep.
Tanner AR, Cilvik SN, Nguyen MA, Dobrinskikh E, Anthony RV, Wesolowski SR, Rozance PJ.
Int J Mol Sci. 2025 Feb 22;26(5):1904. doi: 10.3390/ijms26051904.PMID: 40076531 Free PMC article.

Maternal Western Diet Programmes Bile Acid Dysregulation and Hepatic Fibrosis in Fetal and Juvenile Macaques.
Nash MJ, Dobrinskikh E, Al-Juboori SI, Janssen RC, Fernandes J, Argabright A, D'Alessandro A, Kirigiti MA, Kievit P, Aagaard KM, McCurdy CE, Gannon M, Jones KL, Li T, Friedman JE, Wesolowski SR.
Liver Int. 2025 Feb;45(2):e16236. doi: 10.1111/liv.16236.PMID: 39865409 Free PMC article.

Nbeal2 knockout mice are not protected against hypoxia-induced pulmonary vascular remodeling and pulmonary hypertension.
Posey JN, Jordan M, Lewis CV, Sul C, Dobrinskikh E, Swindle D, Denorme F, Irwin D, Di Paola J, Stenmark K, Nozik ES, Delaney C.
Blood Adv. 2025 Apr 8;9(7):1571-1584. doi: 10.1182/bloodadvances.2024013880.PMID: 39693512 Free PMC article.

EBNEO Commentary: Is Therapeutic Hypothermia Beneficial to Infants Born Between 33 and 35 Weeks Gestation?
Spahic H, Zoubovsky SP, Dietz RM.
Acta Paediatr. 2025 Jul;114(7):1742-1743. doi: 10.1111/apa.70098. Epub 2025 Apr 18.PMID: 40251839 No abstract available.

A novel peptide inhibitor of TRPM2 channels improves recovery of memory function following traumatic brain injury.
Orfila JE, Dietz RM, Schroeder C, Patsos OP, Burch A, Bahamonde KE, Coakley KA, Carter DJ, Clevenger AC, Hendry-Hofer TB, Le TD, Maddry JK, Schauer SG, Bebarta VS, Herson PS.
Front Synaptic Neurosci. 2025 Apr 25;17:1534379. doi: 10.3389/fnsyn.2025.1534379. eCollection 2025.PMID: 40352737 Free PMC article.

Vascular EC-SOD limits the accumulation, proinflammatory profibrotic reprogramming, and hyaluronan binding of interstitial macrophages in hypoxia.
Lewis CV, Nguyen TN, Porfilio TE, Burciaga SD, Posey JN, Jordan M, Colon Hidalgo D, Stenmark KR, Mickael C, Sul C, Oberley-Deegan RE, Delaney C, Nozik ES.
Am J Physiol Lung Cell Mol Physiol. 2025 Jun 1;328(6):L885-L900. doi: 10.1152/ajplung.00399.2024. Epub 2025 May 7.PMID: 40332405 Free article.

Hypoxic pregnancy promotes fibrosis and increases stress metabolites in the ovine fetal liver.
McGuckin MM, Wang D, Ortiz J, Dobrinskikh E, Tong W, Botting-Lawford KJ, Niu Y, Giussani DA, Wesolowski SR.
J Physiol. 2025 May;603(10):3223-3243. doi: 10.1113/JP288724. Epub 2025 May 5.PMID: 40320974 Free PMC article.

Increased Circulating Extracellular Superoxide Dismutase Attenuates Platelet-Neutrophil Interactions.
Sul C, Lewis CV, Posey J, Jordan M, Colon Hidalgo D, Porfilio T, Elajaili H, McCormack G, Burciaga S, Delaney C, Nozik ES.
Am J Respir Cell Mol Biol. 2025 Jun;72(6):653-662. doi: 10.1165/rcmb.2024-0292OC.PMID: 39531632

NIH-funded neonatologist physician-scientists: an exploration of equity and success.
Horowitz EN, Good M, Machut KZ, Ahmad K, Wright CJ, Lingappan K.
Pediatr Res. 2025 Jun 30. doi: 10.1038/s41390-025-04224-5. Online ahead of print.PMID: 40588553

January-June 2024

GSK3β/NF-κB -dependent transcriptional regulation of homeostatic hepatocyte Tnf production.
Grayck MR, McCarthy WC, Solar M, Golden E, Balasubramaniyan N, Zheng L, Sherlock LG, Wright CJ.Am J Physiol Gastrointest Liver Physiol. 2024 Apr 1;326(4):G374-G384. doi: 10.1152/ajpgi.00229.2023. Epub 2024 Jan 9.PMID: 38193163

Altered metabolism and DAM-signatures in female brains and microglia with aging.
Cleland NRW, Potter GJ, Buck C, Quang D, Oldham D, Neal M, Saviola A, Niemeyer CS, Dobrinskikh E, Bruce KD.
Brain Res. 2024 Apr 15;1829:148772. doi: 10.1016/j.brainres.2024.148772. Epub 2024 Jan 18.PMID: 38244754

Isolating mononuclear cells from fetal bone and liver for metabolic, functional, and immunophenotypic analyses in nonhuman primates.
Nash MJ, Dobrinskikh E, Wang D, Pietras EM, Janssen RC, Friedman JE, Wesolowski SR.
STAR Protoc. 2024 Mar 15;5(1):102849. doi: 10.1016/j.xpro.2024.102849. Epub 2024 Feb 6.PMID: 38324447 Free PMC article.

Increasing maternal glucose concentrations is insufficient to restore placental glucose transfer in chorionic somatomammotropin RNA interference pregnancies.
Tanner AR, Kennedy VC, Lynch CS, Winger QA, Anthony RV, Rozance PJ.
Am J Physiol Endocrinol Metab. 2024 May 1;326(5):E602-E615. doi: 10.1152/ajpendo.00331.2023. Epub 2024 Feb 14.PMID: 38353640

Implications of neonatal absence of innate immune mediated NFκB/AP1 signaling in the murine liver.
Grayck MR, McCarthy WC, Solar M, Balasubramaniyan N, Zheng L, Orlicky DJ, Wright CJ.
Pediatr Res. 2024 Jun;95(7):1791-1802. doi: 10.1038/s41390-024-03071-0. Epub 2024 Feb 23.PMID: 38396130

Placental differences between severe fetal growth restriction and hypertensive disorders of pregnancy requiring early preterm delivery: morphometric analysis of the villous tree supported by artificial intelligence.
Jacobs A, Al-Juboori SI, Dobrinskikh E, Bolt MA, Sammel MD, Lijewski V, Post MD, Small JM, Su EJ.
Am J Obstet Gynecol. 2024 Feb 27:S0002-9378(24)00370-3. doi: 10.1016/j.ajog.2024.02.291. Online ahead of print.PMID: 38423447

Dysregulation of miRNA-mRNA expression in fetal growth restriction in a caloric restricted mouse model.
Gallagher LT, Bardill J, Sucharov CC, Wright CJ, Karimpour-Fard A, Zarate M, Breckenfelder C, Liechty KW, Derderian SC.
Sci Rep. 2024 Mar 7;14(1):5579. doi: 10.1038/s41598-024-56155-6.PMID: 38448721 Free PMC article.

Prevention of Inflammatory Disorders in the Preterm Neonate: An Update with a Special Focus on Bronchopulmonary Dysplasia.
Glaser K, Jensen EA, Wright CJ.
Neonatology. 2024 Jun 13:1-10. doi: 10.1159/000539303. Online ahead of print.PMID: 38870912 Review.

Heart rate characteristics predict risk of mortality in preterm infants in low and high target oxygen saturation ranges.
King WE, Sanghvi UJ, Ambalavanan N, Shukla VV, Travers CP, Schelonka RL, Wright C, Carlo WA.
ERJ Open Res. 2024 Jul 15;10(4):00782-2023. doi: 10.1183/23120541.00782-2023. eCollection 2024 Jul. PMID: 39010885

Maternal AMPK pathway activation with uterine artery blood flow and fetal growth maintenance during hypoxia.
Moore LG, Lorca RA, Gumina DL, Wesolowski SR, Reisz JA, Cioffi-Ragan D, Houck JA, Banerji S, Euser AG, D'Alessandro A, Hobbins JC, Julian CG.
Am J Physiol Heart Circ Physiol. 2024 Oct 1;327(4):H778-H792. doi: 10.1152/ajpheart.00193.2024. Epub 2024 Jul 19. PMID: 39028630

Neonatal cardiopulmonary resuscitation: is ROSC enough?
Dietz RM, Gonzalez FF.
Pediatr Res. 2024 Oct;96(5):1123-1124. doi: 10.1038/s41390-024-03398-8. Epub 2024 Jul 24. PMID: 39048670

Analysis of beta-cell maturity and mitochondrial morphology in juvenile non-human primates exposed to maternal Western-style diet during development.
Carroll DT, Miller A, Fuhr J, Elsakr JM, Ricciardi V, Del Bene AN, Stephens S, Krystofiak E, Lindsley SR, Kirigiti M, Takahashi DL, Dean TA, Wesolowski SR, McCurdy CE, Friedman JE, Aagaard KM, Kievit P, Gannon M.
Front Endocrinol (Lausanne). 2024 Jul 24;15:1417437. doi: 10.3389/fendo.2024.1417437. eCollection 2024. PMID: 39114287

Acetaminophen for Patent Ductus Arteriosus and Risk of Mortality and Pulmonary Morbidity.
Jensen EA, DeMauro SB, Rysavy MA, Patel RM, Laughon MM, Eichenwald EC, Do BT, Das A, Wright CJ; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.
Pediatrics. 2024 Aug 1;154(2):e2023065056. doi: 10.1542/peds.2023-065056. PMID: 39011550

EBNEO commentary: Nutritional support for moderate-to-late-preterm infants-A randomized trial.
Dear T, Stremming J.
Acta Paediatr. 2024 Nov;113(11):2491-2492. doi: 10.1111/apa.17382. Epub 2024 Aug 8. PMID: 39115963

Lung EC-SOD Overexpression Prevents Hypoxia-Induced Platelet Activation and Lung Platelet Accumulation.
Colon Hidalgo D, Jordan M, Posey JN, Burciaga SD, Nguyen TN, Sul C, Lewis CV, Delaney C, Nozik ES.
Antioxidants (Basel). 2024 Aug 10;13(8):975. doi: 10.3390/antiox13080975. PMID: 39199221

Variability in Diagnosis and Management of Hypoglycemia in Neonatal Intensive Care Unit.
Dinu D, Hagan JL, Rozance PJ.
Am J Perinatol. 2024 Apr 2. doi: 10.1055/s-0044-1785491. Online ahead of print.PMID: 38565171

Absence of Metformin in Fetal Circulation Following Maternal Administration in Late Gestation Pregnant Sheep.
Rozance PJ, Brown LD, Wesolowski SR.
Reprod Sci. 2024 Jun;31(6):1763-1766. doi: 10.1007/s43032-024-01547-2. Epub 2024 Apr 23.PMID: 38653860 Free PMC article.

Fetal Hypoglycemia Induced by Placental SLC2A3-RNA Interference Alters Fetal Pancreas Development and Transcriptome at Mid-Gestation.
Kennedy VC, Lynch CS, Tanner AR, Winger QA, Gad A, Rozance PJ, Anthony RV.
Int J Mol Sci. 2024 Apr 27;25(9):4780. doi: 10.3390/ijms25094780.PMID: 38731997 Free PMC article.

Increased hepatic glucose production with lower oxidative metabolism in the growth-restricted fetus.
Brown LD, Rozance PJ, Wang D, Eroglu EC, Wilkening RB, Solmonson A, Wesolowski SR.
JCI Insight. 2024 Apr 30;9(10):e176497. doi: 10.1172/jci.insight.176497.PMID: 38687612 Free PMC article.

Mitochondrial respiration is lower in the intrauterine growth-restricted fetal sheep heart.
Chang EI, Stremming J, Knaub LA, Wesolowski SR, Rozance PJ, Sucharov CC, Reusch JEB, Brown LD.
J Physiol. 2024 Jun;602(12):2697-2715. doi: 10.1113/JP285496. Epub 2024 May 14.PMID: 38743350

IGF-1 infusion increases growth in fetal sheep when euinsulinemia is maintained.
Stremming J, Chang EI, White A, Rozance PJ, Brown LD.
J Endocrinol. 2024 Jun 7;262(1):e240058. doi: 10.1530/JOE-24-0058. Print 2024 Jul 1.PMID: 38727325 Free PMC article

Initiation of metformin in early pregnancy results in fetal bioaccumulation, growth restriction, and renal dysmorphology in a primate model.
Bolte E, Dean T, Garcia B, Seferovic MD, Sauter K, Hummel G, Bucher M, Li F, Hicks J, Qin X, Suter MA, Barrozo ER, Jochum M, Shope C, Friedman JE, Gannon M, Wesolowski SR, McCurdy CE, Kievit P, Aagaard KM.
Am J Obstet Gynecol. 2024 Sep;231(3):352.e1-352.e16. doi: 10.1016/j.ajog.2024.06.002. Epub 2024 Jun 11.PMID: 38871238 Free article.

IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep.
White A, Stremming J, Wesolowski SR, Al-Juboori SI, Dobrinskikh E, Limesand SW, Brown LD, Rozance PJ.
Am J Physiol Endocrinol Metab. 2025 Jan 1;328(1):E116-E125. doi: 10.1152/ajpendo.00259.2024. Epub 2024 Dec 16. PMID: 39679943

Nbeal2 Knockout Mice Are Not Protected Against Hypoxia-Induced Pulmonary Vascular Remodeling and Pulmonary Hypertension.
Posey J, Jordan M, Lewis CV, Sul C, Dobrinskikh E, Swindle D, Denorme F, Irwin D, Di Paola J, Stenmark K, Nozik E, Delaney C.
Blood Adv. 2024 Dec 18:bloodadvances.2024013880. doi: 10.1182/bloodadvances.2024013880. Online ahead of print. PMID: 39693512