Recent PRC Faculty Publications

January-December 2023

Clinical decision thresholds for surfactant administration in preterm infants: a systematic review and network meta-analysis.

Ramaswamy VV, Bandyopadhyay T, Abiramalatha T, Pullattayil S AK, Szczapa T, Wright CJ, Roehr CC.

EClinicalMedicine. 2023 Jul 20;62:102097. doi: 10.1016/j.eclinm.2023.102097. eCollection 2023 Aug.PMID: 37538537 Free PMC article.

Term Neonate with Progressive Respiratory Distress.

Harding E, Hill LR, Black JO, Annam A, Wright CJ.

J Pediatr. 2023 Dec;263:113704. doi: 10.1016/j.jpeds.2023.113704. Epub 2023 Aug 26.PMID: 37640231 No abstract available.

Angiogenic and Inflammatory microRNA Regulation in a Mouse Model of Fetal Growth Restriction.

Gallagher LT, Wright CJ, Lehmann T, Khailova L, Zarate M, Lyttle BD, Liechty KW, Derderian SC.

J Surg Res. 2023 Dec;292:234-238. doi: 10.1016/j.jss.2023.07.052. Epub 2023 Aug 30.PMID: 37657141

Metformin Disrupts Signaling and Metabolism in Fetal Hepatocytes.

Swenson KS, Wang D, Jones AK, Nash MJ, O'Rourke R, Takahashi DL, Kievit P, Hennebold JD, Aagaard KM, Friedman JE, Jones KL, Rozance PJ, Brown LD, Wesolowski SR.

Diabetes. 2023 Sep 1;72(9):1214-1227. doi: 10.2337/db23-0089.PMID: 37347736

Metabolic and fecal microbial changes in adult fetal growth restricted mice.

Gilley SP, Zarate MA, Zheng L, Jambal P, Yazza DN, Chintapalli SV, MacLean PS, Wright CJ, Rozance PJ, Shankar K.

Pediatr Res. 2023 Nov 7. doi: 10.1038/s41390-023-02869-8. Online ahead of print.PMID: 37935884

Altered Metabolism and DAM-signatures in Female Brains and Microglia with Aging.

Cleland NRW, Potter GJ, Buck C, Quang D, Oldham D, Neal M, Saviola A, Niemeyer CS, Dobrinskikh E, Bruce KD.

bioRxiv. 2023 Nov 30:2023.11.28.569104. doi: 10.1101/2023.11.28.569104. Preprint.PMID: 38076915 Free PMC article.

SIRT3 Is a Critical Regulator of Mitochondrial Function of Fibroblasts in Pulmonary Hypertension.

Li M, Plecitá-Hlavatá L, Dobrinskikh E, McKeon BA, Gandjeva A, Riddle S, Laux A, Prasad RR, Kumar S, Tuder RM, Zhang H, Hu CJ, Stenmark KR.

Am J Respir Cell Mol Biol. 2023 Nov;69(5):570-583. doi: 10.1165/rcmb.2022-0360OC.PMID: 37343939

Potential Adjuncts to Therapeutic Hypothermia to Mitigate Multiorgan Injury in Perinatal Hypoxia-Ischemia.

Turner MJ, Dietz RM.

Neoreviews. 2023 Dec 1;24(12):e771-e782. doi: 10.1542/neo.24-12-e771.PMID: 38036441

A Maternal Western-Style Diet Impairs Skeletal Muscle Lipid Metabolism in Adolescent Japanese Macaques.

Greyslak KT, Hetrick B, Bergman BC, Dean TA, Wesolowski SR, Gannon M, Schenk S, Sullivan EL, Aagaard KM, Kievit P, Chicco AJ, Friedman JE, McCurdy CE.

Diabetes. 2023 Dec 1;72(12):1766-1780. doi: 10.2337/db23-0289.PMID: 37725952

Targeting optimal protein delivery in parenteral and enteral nutrition for preterm infants: a review of randomized, controlled trials.

Brown LD, Stremming J, Robinson DT.

J Perinatol. 2023 Dec 20. doi: 10.1038/s41372-023-01847-6. Online ahead of print.PMID: 38123801

Proceedings of the 14th International Newborn Brain Conference: Neuroprotection strategies in the neonate.

Abdurajan S, Ågren J, Alt J, Axelin A, Bäcke P, Balashova E, Thernström Blomqvist Y, Burckhard Z, Burnsed J, Cornaz Buros S, Chavez-Valdez R, Chen M, Dickie J, Dietz R, Dingman A, Doucette L, El-Dib M, Shibiny H, Flock D, Ganal S, Gorse K, Guo J, Harrison S, Herrmann J, Ionov O, Jackson T, Janesko-Feldman K, Jantzie L, June A, Kathiresh S, Kirtbaya A, Klein A, Kochanek P, Kuter N, Marlicz M, Martin LJ, Matysik W, Munster C, Northington FJ, Quilinan N, Rais R, Schöberlein A, Sharafutdinova D, Suvorov MSI, Suvorova J, Szakmar E, Tiemeier E, Tran P, Trigo NF, Turnbill V, Ushakova L, Vagni V.J Neonatal Perinatal Med. 2023;16(s1):S21-S31. doi: 10.3233/NPM-239002.PMID: 37599541

Maternal Western diet is associated with distinct preclinical pediatric NAFLD phenotypes in juvenile nonhuman primate offspring.

Nash MJ, Dobrinskikh E, Janssen RC, Lovell MA, Schady DA, Levek C, Jones KL, D'Alessandro A, Kievit P, Aagaard KM, McCurdy CE, Gannon M, Friedman JE, Wesolowski SR.

Hepatol Commun. 2023 Jan 18;7(2):e0014. doi: 10.1097/HC9.0000000000000014. eCollection 2023 Feb 1.PMID: 36691970 Free PMC article.

Bacterial DNA amplifies neutrophilic inflammation in IL-17-exposed airways.

Mues N, Martin RJ, Alam R, Schaunaman N, Dimasuay KG, Kolakowski C, Wright CJ, Zheng L, Chu HW.

ERJ Open Res. 2023 Jan 23;9(1):00474-2022. doi: 10.1183/23120541.00474-2022. eCollection 2023 Jan.PMID: 36699649 Free PMC article.

Platelets and ductus arteriosus closure in neonates.

Sallmon H, Delaney CA.

Semin Perinatol. 2023 Mar;47(2):151719. doi: 10.1016/j.semperi.2023.151719. Epub 2023 Mar 1.PMID: 36925318 Free article. Clinical Trial.

Imbalanced Inflammatory Responses in Preterm and Term Cord Blood Monocytes and Expansion of the CD14⁺CD16⁺ Subset upon Toll-like Receptor Stimulation.

Glaser K, Kern D, Speer CP, Schlegel N, Schwab M, Thome UH, Härtel C, Wright CJ.

Int J Mol Sci. 2023 Mar 3;24(5):4919. doi: 10.3390/ijms24054919.PMID: 36902350 Free PMC article.

EBNEO commentary: Early amino acids in extremely preterm infants and neurodisability at 2 years.

Stremming J, Brown LD.

Acta Paediatr. 2023 Jul;112(7):1605-1606. doi: 10.1111/apa.16774. Epub 2023 Mar 31.PMID: 36999344 No abstract available.

Maternal diet alters long-term innate immune cell memory in fetal and juvenile hematopoietic stem and progenitor cells in nonhuman primate offspring.

Nash MJ, Dobrinskikh E, Soderborg TK, Janssen RC, Takahashi DL, Dean TA, Varlamov O, Hennebold JD, Gannon M, Aagaard KM, McCurdy CE, Kievit P, Bergman BC, Jones KL, Pietras EM, Wesolowski SR, Friedman JE.

Cell Rep. 2023 Apr 13;42(4):112393. doi: 10.1016/j.celrep.2023.112393. Online ahead of print.PMID: 37058409 Free article.

Adaptive responses in uteroplacental metabolism and fetoplacental nutrient shuttling and sensing during placental insufficiency.

Kyllo HM, Wang D, Lorca RA, Julian CG, Moore LG, Wilkening RB, Rozance PJ, Brown LD, Wesolowski SR.

Am J Physiol Endocrinol Metab. 2023 Jun 1;324(6):E556-E568. doi: 10.1152/ajpendo.00046.2023. Epub 2023 Apr 26.PMID: 37126847

Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets.

White A, Stremming J, Brown LD, Rozance PJ.

J Dev Orig Health Dis. 2023 Jun;14(3):353-361. doi: 10.1017/S2040174423000090. Epub 2023 Apr 28.PMID: 37114757

Neonatal exposure to a neuroactive steroid alters low-frequency oscillations in the subiculum.

Fine-Raquet B, Manzella FM, Joksimovic SM, Dietz RM, Orfila JE, Sampath D, Tesic V, Atluri N, Covey DF, Raol YH, Jevtovic-Todorovic V, Herson PS, Todorovic SM.

Exp Biol Med (Maywood). 2023 Apr;248(7):578-587. doi: 10.1177/15353702231177009. Epub 2023 Jun 13.PMID: 37309730 Review.

EBNEO commentary: Platelet transfusions in neonates and brain development: The new frontier.

Sola-Visner M, Delaney C, Davenport P.

Acta Paediatr. 2023 Aug;112(8):1826-1827. doi: 10.1111/apa.16801. Epub 2023 May 1.PMID: 37128679 No abstract available.

Innate Immune Zonation in the Liver: NF-κB (p50) Activation and C-Reactive Protein Expression in Response to Endotoxemia Are Zone Specific.

McCarthy WC, Sherlock LG, Grayck MR, Zheng L, Lacayo OA, Solar M, Orlicky DJ, Dobrinskikh E, Wright CJ.

J Immunol. 2023 May 1;210(9):1372-1385. doi: 10.4049/jimmunol.2200900.PMID: 36946778

Maternal Western-style diet in nonhuman primates leads to offspring islet adaptations including altered gene expression and insulin hypersecretion.

Carroll DT, Elsakr JM, Miller A, Fuhr J, Lindsley SR, Kirigiti M, Takahashi DL, Dean TA, Wesolowski SR, McCurdy CE, Friedman JE, Aagaard KM, Kievit P, Gannon M.Am J Physiol Endocrinol Metab. 2023 Jun 1;324(6):E577-E588. doi: 10.1152/ajpendo.00087.2023. Epub 2023 May 3.PMID: 37134140

Acetaminophen for the patent ductus arteriosus: has safety been adequately demonstrated?

Wright CJ, McCulley DJ, Mitra S, Jensen EA.

J Perinatol. 2023 May 11. doi: 10.1038/s41372-023-01697-2. Online ahead of print.PMID: 37169914 Review.

RDS-NExT workshop: consensus statements for the use of surfactant in preterm neonates with RDS.

Bhandari V, Black R, Gandhi B, Hogue S, Kakkilaya V, Mikhael M, Moya F, Pezzano C, Read P, Roberts KD, Ryan RM, Stanford RH, Wright CJ.

J Perinatol. 2023 May 15. doi: 10.1038/s41372-023-01690-9. Online ahead of print.PMID: 37188774

Impact of Chorionic Somatomammotropin In Vivo RNA Interference Phenotype on Uteroplacental Expression of the IGF Axis.

Hord TK, Tanner AR, Kennedy VC, Lynch CS, Winger QA, Rozance PJ, Anthony RV.

Life (Basel). 2023 May 26;13(6):1261. doi: 10.3390/life13061261.PMID: 37374044 Free PMC article.

SIRT3 Is a Critical Regulator of Mitochondrial Function of Fibroblasts in Pulmonary Hypertension.

Li M, Plecitá-Hlavatá L, Dobrinskikh E, McKeon BA, Gandjeva A, Riddle S, Laux A, Prasad RR, Kumar S, Tuder RM, Zhang H, Hu CJ, Stenmark KR.

Am J Respir Cell Mol Biol. 2023 Jun 21. doi: 10.1165/rcmb.2022-0360OC. Online ahead of print.PMID: 37343939

Metformin Disrupts Signaling and Metabolism in Fetal Hepatocytes.

Swenson KS, Wang D, Jones AK, Nash MJ, O'Rourke R, Takahashi DL, Kievit P, Hennebold JD, Aagaard KM, Friedman JE, Jones KL, Rozance PJ, Brown LD, Wesolowski SR.

Diabetes. 2023 Jun 22:db230089. doi: 10.2337/db23-0089. Online ahead of print.PMID: 37347736

Chronic Fetal Leucine Infusion Increases Rate of Leucine Oxidation but Not of Protein Synthesis in Late Gestation Fetal Sheep.

Rozance PJ, Boehmer BH, Chang EI, Wesolowski SR, Brown LD.

J Nutr. 2023 Feb;153(2):493-504. doi: 10.1016/j.tjnut.2022.12.027. Epub 2022 Dec 30.PMID: 36894241

Re-examination of the estimated average requirement for carbohydrate intake during pregnancy: Addition of placental glucose consumption.

Hernandez TL, Rozance PJ.

Am J Clin Nutr. 2023 Feb;117(2):227-234. doi: 10.1016/j.ajcnut.2022.09.005. Epub 2022 Dec 19.PMID: 36811561 Review.

January-December 2022

Coronary conductance in the normal development of sheep during the perinatal period.

Hagen MW, Louey S, Alaniz SM, Brown L, Lindner JR, Jonker SS.Physiol Rep. 2022 Dec;10(23):e15523. doi: 10.14814/phy2.15523.PMID: 36461657 Free PMC article.

Changes in microvascular perfusion of heart and skeletal muscle in sheep around the time of birth.

Hagen MW, Louey S, Alaniz SM, Belcik T, Muller MM, Brown L, Lindner JR, Jonker SS.Exp Physiol. 2023 Jan;108(1):135-145. doi: 10.1113/EP090809. Epub 2022 Nov 24.PMID: 36420621

Neonatal Selenium Deficiency Decreases Selenoproteins in the Lung and Impairs Pulmonary Alveolar Development.

Sherlock LG, McCarthy WC, Grayck MR, Solar M, Hernandez A, Zheng L, Delaney C, Tipple TE, Wright CJ, Nozik ES.Antioxidants (Basel). 2022 Dec 7;11(12):2417. doi: 10.3390/antiox11122417.PMID: 36552625 Free PMC article.

Serotonin-deficient neonatal mice are not protected against the development of experimental bronchopulmonary dysplasia or pulmonary hypertension.

Roberts DS, Sherlock LG, Posey JN, Archambault JL, Nozik ES, Delaney CA.Physiol Rep. 2022 Oct;10(19):e15482. doi: 10.14814/phy2.15482.PMID: 36200294 Free PMC article.

Zoster-associated Prothrombotic Plasma Exosomes and Increased Stroke Risk.

Bubak AN, Coughlan C, Posey J, Saviola AJ, Niemeyer CS, Lewis SWR, Lopez SB, Solano A, Tyring SK, Delaney C, Neeves KB, Mahalingam R, Hansen KC, Nagel MA.J Infect Dis. 2022 Oct 6:jiac405. doi: 10.1093/infdis/jiac405. Online ahead of print.PMID: 36200236

Cerebral ischemia in the developing brain.

Dietz RM, Dingman AL, Herson PS.J Cereb Blood Flow Metab. 2022 Oct;42(10):1777-1796. doi: 10.1177/0271678X221111600. Epub 2022 Jun 29.PMID: 35765984 Review

Impact of Placental SLC2A3 Deficiency during the First-Half of Gestation.

Lynch CS, Kennedy VC, Tanner AR, Ali A, Winger QA, Rozance PJ, Anthony RV.Int J Mol Sci. 2022 Oct 19;23(20):12530. doi: 10.3390/ijms232012530.PMID: 36293384 Free PMC article.

Uptake of Phosphate, Calcium, and Vitamin D by the Pregnant Uterus of Sheep in Late Gestation: Regulation by Chorionic Somatomammotropin Hormone.

Stenhouse C, Halloran KM, Tanner AR, Suva LJ, Rozance PJ, Anthony RV, Bazer FW.Int J Mol Sci. 2022 Jul 14;23(14):7795. doi: 10.3390/ijms23147795.PMID: 35887141 Free PMC article.

Maternal Western-style diet remodels the transcriptional landscape of fetal hematopoietic stem and progenitor cells in rhesus macaques.

Sureshchandra S, Chan CN, Robino JJ, Parmelee LK, Nash MJ, Wesolowski SR, Pietras EM, Friedman JE, Takahashi D, Shen W, Jiang X, Hennebold JD, Goldman D, Packwood W, Lindner JR, Roberts CT Jr, Burwitz BJ, Messaoudi I, Varlamov O.Stem Cell Reports. 2022 Dec 13;17(12):2595-2609. doi: 10.1016/j.stemcr.2022.10.003. Epub 2022 Nov 3.PMID: 36332628 Free PMC article.

Why is human uterine artery blood flow during pregnancy so high?

Moore LG, Wesolowski SR, Lorca RA, Murray AJ, Julian CG.Am J Physiol Regul Integr Comp Physiol. 2022 Nov 1;323(5):R694-R699. doi: 10.1152/ajpregu.00167.2022. Epub 2022 Sep 12.PMID: 36094446

Can we balance early exogenous surfactant therapy and non-invasive respiratory support to optimise outcomes in extremely preterm infants? A nuanced review of the current literature.

Glaser K, Bamat NA, Wright CJ.Arch Dis Child Fetal Neonatal Ed. 2022 Dec 7:fetalneonatal-2022-324530. doi: 10.1136/archdischild-2022-324530. Online ahead of print.PMID: 36600473 Review.

Absence of IκBβ/NFκB signaling does not attenuate acetaminophen-induced hepatic injury.

Solar M, Grayck MR, McCarthy WC, Zheng L, Lacayo OA, Sherlock LG, Zhou R, Orlicky DJ, Wright CJ.Anat Rec (Hoboken). 2022 Nov 25. doi: 10.1002/ar.25126. Online ahead of print.PMID: 36426684

Perinatal Research Society's Young Investigator Workshop Prepares the Next Generation of Investigators.

Joss-Moore LA, Lane RH, Rozance PJ, Bird I, Albertine KH.

Reprod Sci. 2022 Apr;29(4):1271-1277. doi: 10.1007/s43032-021-00836-4.

Epub (2022 Jan 12) PMID: 35020187 Free PMC article.

APAP-Induced IκBβ/NFκB Signaling Drives Hepatic Il6 Expression and Associated Sinusoidal Dilation.

Sherlock LG, Balasubramaniyan D, Zheng L, Grayck M, McCarthy WC, De Dios RC, Zarate MA, Orlicky DJ, De Dios R, Wright CJ.

Toxicol Sci.;185(2):158-169. doi: 10.1093/toxsci/kfab131.

(2022 Jan 24) PMID: 34726736 Free PMC article.

EBNEO Commentary: Paracetamol/acetaminophen to avoid PDA ligation: How to interpret impact on 18- to 24-month outcomes.

Wright CJ, Jensen EA.

Acta Paediatr. 2022 Apr;111(4):901-902. doi: 10.1111/apa.16238.

Epub (2022 Jan 31) PMID: 35099086 No abstract available.

EBNEO Commentary: OPTIMIST-ically moving towards targeted noninvasive surfactant therapy?

Wright CJ, Glaser K, Bamat NA.

Acta Paediatr. 2022 May;111(5):1091-1092. doi: 10.1111/apa.16261.

Epub (2022 Jan 31) PMID: 35100470 No abstract available.

Metabolism, Mitochondrial Dysfunction, and Redox Homeostasis in Pulmonary Hypertension.

Colon Hidalgo D, Elajaili H, Suliman H, George MP, Delaney C, Nozik E.

Antioxidants (Basel);11(2):428. doi: 10.3390/antiox11020428.

(2022 Feb 21) Free PMC article. Review. PMID: 35204311

Hypoglycemia in the Newborn and Neurodevelopmental Outcomes in Childhood.

Rozance PJ.

JAMA;327(12):1135-1137. doi: 10.1001/jama.2022.2456.

(2022 Mar 22) No abstract available. PMID: 35315906 

Differences in hippocampal plasticity and memory outcomes in anterior versus posterior cerebellar stroke.

Moreno M, Minjarez C, Vigil J, Orfila JE, Schmidt R, Burch A, Carter DJ, Kubesh M, Yonchek J, Dietz RM, Quillinan N.

Neurobiol Dis. 2022 Jun 15;168:105701. doi: 10.1016/j.nbd.2022.105701.

Epub (2022 Mar 23) PMID: 35337949 Free PMC article.

Noninvasive Ventilation and Exogenous Surfactant in Times of Ever Decreasing Gestational Age: How Do We Make the Most of These Tools?

Wright CJ, Glaser K, Speer CP, Härtel C, Roehr CC.

J Pediatr:S0022-3476(22)00325-0. doi: 10.1016/j.jpeds.2022.04.011.

Online ahead of print. (2022 Apr 13) No abstract available. PMID: 35429507

Racing against time: leveraging preclinical models to understand pulmonary susceptibility to perinatal acetaminophen exposures.

McCulley DJ, Jensen EA, Sucre JMS, McKenna S, Sherlock LG, Dobrinskikh E, Wright CJ.

Am J Physiol Lung Cell Mol Physiol. 2022 Jul 1;323(1):L1-L13. doi: 10.1152/ajplung.00080.2022.

Epub (2022 May 3) PMID: 35503238 Review.

Pulmonary Resilience: Moderating the Association between Oxygen Exposure and Pulmonary Outcomes in Extremely Preterm Newborns.

Jhaveri Sanghvi U, Wright CJ, Hernandez TL.

Neonatology. 2022;119(4):433-442. doi: 10.1159/000524438.

Epub (2022 May 12) PMID: 35551136 Free article. Review.

EBNEO commentary: Dexmedetomidine versus morphine for neonates with encephalopathy undergoing therapeutic hypothermia.

Welter KJ, Ross E, Dietz R.

Acta Paediatr. doi: 10.1111/apa.16415.

Online ahead of print. (2022 May 26) PMID: 35615949 No abstract available.

In vivo investigation of ruminant placenta function and physiology-a review.

Tanner AR, Kennedy VC, Lynch CS, Hord TK, Winger QA, Rozance PJ, Anthony RV.

J Anim Sci;100(6):skac045. doi: 10.1093/jas/skac045.

(2022 Jun 1) PMID: 35648127 Review.

Cerebral ischemia in the developing brain.

Dietz RM, Dingman AL, Herson PS.

J Cereb Blood Flow Metab:271678X221111600. doi: 10.1177/0271678X221111600.

Online ahead of print. (2022 Jun 29) PMID: 35765984