Recent PRC Faculty Publications

January-June 2024

GSK3β/NF-κB -dependent transcriptional regulation of homeostatic hepatocyte Tnf production.

Grayck MR, McCarthy WC, Solar M, Golden E, Balasubramaniyan N, Zheng L, Sherlock LG, Wright CJ.Am J Physiol Gastrointest Liver Physiol. 2024 Apr 1;326(4):G374-G384. doi: 10.1152/ajpgi.00229.2023. Epub 2024 Jan 9.PMID: 38193163

Altered metabolism and DAM-signatures in female brains and microglia with aging.

Cleland NRW, Potter GJ, Buck C, Quang D, Oldham D, Neal M, Saviola A, Niemeyer CS, Dobrinskikh E, Bruce KD.

Brain Res. 2024 Apr 15;1829:148772. doi: 10.1016/j.brainres.2024.148772. Epub 2024 Jan 18.PMID: 38244754

Isolating mononuclear cells from fetal bone and liver for metabolic, functional, and immunophenotypic analyses in nonhuman primates.

Nash MJ, Dobrinskikh E, Wang D, Pietras EM, Janssen RC, Friedman JE, Wesolowski SR.

STAR Protoc. 2024 Mar 15;5(1):102849. doi: 10.1016/j.xpro.2024.102849. Epub 2024 Feb 6.PMID: 38324447 Free PMC article.

Increasing maternal glucose concentrations is insufficient to restore placental glucose transfer in chorionic somatomammotropin RNA interference pregnancies.

Tanner AR, Kennedy VC, Lynch CS, Winger QA, Anthony RV, Rozance PJ.

Am J Physiol Endocrinol Metab. 2024 May 1;326(5):E602-E615. doi: 10.1152/ajpendo.00331.2023. Epub 2024 Feb 14.PMID: 38353640

Implications of neonatal absence of innate immune mediated NFκB/AP1 signaling in the murine liver.

Grayck MR, McCarthy WC, Solar M, Balasubramaniyan N, Zheng L, Orlicky DJ, Wright CJ.

Pediatr Res. 2024 Jun;95(7):1791-1802. doi: 10.1038/s41390-024-03071-0. Epub 2024 Feb 23.PMID: 38396130

Placental differences between severe fetal growth restriction and hypertensive disorders of pregnancy requiring early preterm delivery: morphometric analysis of the villous tree supported by artificial intelligence.

Jacobs A, Al-Juboori SI, Dobrinskikh E, Bolt MA, Sammel MD, Lijewski V, Post MD, Small JM, Su EJ.

Am J Obstet Gynecol. 2024 Feb 27:S0002-9378(24)00370-3. doi: 10.1016/j.ajog.2024.02.291. Online ahead of print.PMID: 38423447

Dysregulation of miRNA-mRNA expression in fetal growth restriction in a caloric restricted mouse model.

Gallagher LT, Bardill J, Sucharov CC, Wright CJ, Karimpour-Fard A, Zarate M, Breckenfelder C, Liechty KW, Derderian SC.

Sci Rep. 2024 Mar 7;14(1):5579. doi: 10.1038/s41598-024-56155-6.PMID: 38448721 Free PMC article.

Variability in Diagnosis and Management of Hypoglycemia in Neonatal Intensive Care Unit.

Dinu D, Hagan JL, Rozance PJ.

Am J Perinatol. 2024 Apr 2. doi: 10.1055/s-0044-1785491. Online ahead of print.PMID: 38565171

Absence of Metformin in Fetal Circulation Following Maternal Administration in Late Gestation Pregnant Sheep.

Rozance PJ, Brown LD, Wesolowski SR.

Reprod Sci. 2024 Jun;31(6):1763-1766. doi: 10.1007/s43032-024-01547-2. Epub 2024 Apr 23.PMID: 38653860 Free PMC article.

Fetal Hypoglycemia Induced by Placental SLC2A3-RNA Interference Alters Fetal Pancreas Development and Transcriptome at Mid-Gestation.

Kennedy VC, Lynch CS, Tanner AR, Winger QA, Gad A, Rozance PJ, Anthony RV.

Int J Mol Sci. 2024 Apr 27;25(9):4780. doi: 10.3390/ijms25094780.PMID: 38731997 Free PMC article.

Increased hepatic glucose production with lower oxidative metabolism in the growth-restricted fetus.

Brown LD, Rozance PJ, Wang D, Eroglu EC, Wilkening RB, Solmonson A, Wesolowski SR.

JCI Insight. 2024 Apr 30;9(10):e176497. doi: 10.1172/jci.insight.176497.PMID: 38687612 Free PMC article.

Mitochondrial respiration is lower in the intrauterine growth-restricted fetal sheep heart.

Chang EI, Stremming J, Knaub LA, Wesolowski SR, Rozance PJ, Sucharov CC, Reusch JEB, Brown LD.

J Physiol. 2024 Jun;602(12):2697-2715. doi: 10.1113/JP285496. Epub 2024 May 14.PMID: 38743350

IGF-1 infusion increases growth in fetal sheep when euinsulinemia is maintained.

Stremming J, Chang EI, White A, Rozance PJ, Brown LD.

J Endocrinol. 2024 Jun 7;262(1):e240058. doi: 10.1530/JOE-24-0058. Print 2024 Jul 1.PMID: 38727325 Free PMC article

Initiation of metformin in early pregnancy results in fetal bioaccumulation, growth restriction, and renal dysmorphology in a primate model.

Bolte E, Dean T, Garcia B, Seferovic MD, Sauter K, Hummel G, Bucher M, Li F, Hicks J, Qin X, Suter MA, Barrozo ER, Jochum M, Shope C, Friedman JE, Gannon M, Wesolowski SR, McCurdy CE, Kievit P, Aagaard KM.

Am J Obstet Gynecol. 2024 Sep;231(3):352.e1-352.e16. doi: 10.1016/j.ajog.2024.06.002. Epub 2024 Jun 11.PMID: 38871238 Free article.

Prevention of Inflammatory Disorders in the Preterm Neonate: An Update with a Special Focus on Bronchopulmonary Dysplasia.

Glaser K, Jensen EA, Wright CJ.

Neonatology. 2024 Jun 13:1-10. doi: 10.1159/000539303. Online ahead of print.PMID: 38870912 Review.

January-December 2023

Clinical decision thresholds for surfactant administration in preterm infants: a systematic review and network meta-analysis.

Ramaswamy VV, Bandyopadhyay T, Abiramalatha T, Pullattayil S AK, Szczapa T, Wright CJ, Roehr CC.

EClinicalMedicine. 2023 Jul 20;62:102097. doi: 10.1016/j.eclinm.2023.102097. eCollection 2023 Aug.PMID: 37538537 Free PMC article.

Term Neonate with Progressive Respiratory Distress.

Harding E, Hill LR, Black JO, Annam A, Wright CJ.

J Pediatr. 2023 Dec;263:113704. doi: 10.1016/j.jpeds.2023.113704. Epub 2023 Aug 26.PMID: 37640231 No abstract available.

Angiogenic and Inflammatory microRNA Regulation in a Mouse Model of Fetal Growth Restriction.

Gallagher LT, Wright CJ, Lehmann T, Khailova L, Zarate M, Lyttle BD, Liechty KW, Derderian SC.

J Surg Res. 2023 Dec;292:234-238. doi: 10.1016/j.jss.2023.07.052. Epub 2023 Aug 30.PMID: 37657141

Metformin Disrupts Signaling and Metabolism in Fetal Hepatocytes.

Swenson KS, Wang D, Jones AK, Nash MJ, O'Rourke R, Takahashi DL, Kievit P, Hennebold JD, Aagaard KM, Friedman JE, Jones KL, Rozance PJ, Brown LD, Wesolowski SR.

Diabetes. 2023 Sep 1;72(9):1214-1227. doi: 10.2337/db23-0089.PMID: 37347736

Metabolic and fecal microbial changes in adult fetal growth restricted mice.

Gilley SP, Zarate MA, Zheng L, Jambal P, Yazza DN, Chintapalli SV, MacLean PS, Wright CJ, Rozance PJ, Shankar K.

Pediatr Res. 2023 Nov 7. doi: 10.1038/s41390-023-02869-8. Online ahead of print.PMID: 37935884

Altered Metabolism and DAM-signatures in Female Brains and Microglia with Aging.

Cleland NRW, Potter GJ, Buck C, Quang D, Oldham D, Neal M, Saviola A, Niemeyer CS, Dobrinskikh E, Bruce KD.

bioRxiv. 2023 Nov 30:2023.11.28.569104. doi: 10.1101/2023.11.28.569104. Preprint.PMID: 38076915 Free PMC article.

SIRT3 Is a Critical Regulator of Mitochondrial Function of Fibroblasts in Pulmonary Hypertension.

Li M, Plecitá-Hlavatá L, Dobrinskikh E, McKeon BA, Gandjeva A, Riddle S, Laux A, Prasad RR, Kumar S, Tuder RM, Zhang H, Hu CJ, Stenmark KR.

Am J Respir Cell Mol Biol. 2023 Nov;69(5):570-583. doi: 10.1165/rcmb.2022-0360OC.PMID: 37343939

Potential Adjuncts to Therapeutic Hypothermia to Mitigate Multiorgan Injury in Perinatal Hypoxia-Ischemia.

Turner MJ, Dietz RM.

Neoreviews. 2023 Dec 1;24(12):e771-e782. doi: 10.1542/neo.24-12-e771.PMID: 38036441

A Maternal Western-Style Diet Impairs Skeletal Muscle Lipid Metabolism in Adolescent Japanese Macaques.

Greyslak KT, Hetrick B, Bergman BC, Dean TA, Wesolowski SR, Gannon M, Schenk S, Sullivan EL, Aagaard KM, Kievit P, Chicco AJ, Friedman JE, McCurdy CE.

Diabetes. 2023 Dec 1;72(12):1766-1780. doi: 10.2337/db23-0289.PMID: 37725952

Targeting optimal protein delivery in parenteral and enteral nutrition for preterm infants: a review of randomized, controlled trials.

Brown LD, Stremming J, Robinson DT.

J Perinatol. 2023 Dec 20. doi: 10.1038/s41372-023-01847-6. Online ahead of print.PMID: 38123801

Proceedings of the 14th International Newborn Brain Conference: Neuroprotection strategies in the neonate.

Abdurajan S, Ågren J, Alt J, Axelin A, Bäcke P, Balashova E, Thernström Blomqvist Y, Burckhard Z, Burnsed J, Cornaz Buros S, Chavez-Valdez R, Chen M, Dickie J, Dietz R, Dingman A, Doucette L, El-Dib M, Shibiny H, Flock D, Ganal S, Gorse K, Guo J, Harrison S, Herrmann J, Ionov O, Jackson T, Janesko-Feldman K, Jantzie L, June A, Kathiresh S, Kirtbaya A, Klein A, Kochanek P, Kuter N, Marlicz M, Martin LJ, Matysik W, Munster C, Northington FJ, Quilinan N, Rais R, Schöberlein A, Sharafutdinova D, Suvorov MSI, Suvorova J, Szakmar E, Tiemeier E, Tran P, Trigo NF, Turnbill V, Ushakova L, Vagni V.J Neonatal Perinatal Med. 2023;16(s1):S21-S31. doi: 10.3233/NPM-239002.PMID: 37599541

Maternal Western diet is associated with distinct preclinical pediatric NAFLD phenotypes in juvenile nonhuman primate offspring.

Nash MJ, Dobrinskikh E, Janssen RC, Lovell MA, Schady DA, Levek C, Jones KL, D'Alessandro A, Kievit P, Aagaard KM, McCurdy CE, Gannon M, Friedman JE, Wesolowski SR.

Hepatol Commun. 2023 Jan 18;7(2):e0014. doi: 10.1097/HC9.0000000000000014. eCollection 2023 Feb 1.PMID: 36691970 Free PMC article.

Bacterial DNA amplifies neutrophilic inflammation in IL-17-exposed airways.

Mues N, Martin RJ, Alam R, Schaunaman N, Dimasuay KG, Kolakowski C, Wright CJ, Zheng L, Chu HW.

ERJ Open Res. 2023 Jan 23;9(1):00474-2022. doi: 10.1183/23120541.00474-2022. eCollection 2023 Jan.PMID: 36699649 Free PMC article.

Platelets and ductus arteriosus closure in neonates.

Sallmon H, Delaney CA.

Semin Perinatol. 2023 Mar;47(2):151719. doi: 10.1016/j.semperi.2023.151719. Epub 2023 Mar 1.PMID: 36925318 Free article. Clinical Trial.

Imbalanced Inflammatory Responses in Preterm and Term Cord Blood Monocytes and Expansion of the CD14⁺CD16⁺ Subset upon Toll-like Receptor Stimulation.

Glaser K, Kern D, Speer CP, Schlegel N, Schwab M, Thome UH, Härtel C, Wright CJ.

Int J Mol Sci. 2023 Mar 3;24(5):4919. doi: 10.3390/ijms24054919.PMID: 36902350 Free PMC article.

EBNEO commentary: Early amino acids in extremely preterm infants and neurodisability at 2 years.

Stremming J, Brown LD.

Acta Paediatr. 2023 Jul;112(7):1605-1606. doi: 10.1111/apa.16774. Epub 2023 Mar 31.PMID: 36999344 No abstract available.

Maternal diet alters long-term innate immune cell memory in fetal and juvenile hematopoietic stem and progenitor cells in nonhuman primate offspring.

Nash MJ, Dobrinskikh E, Soderborg TK, Janssen RC, Takahashi DL, Dean TA, Varlamov O, Hennebold JD, Gannon M, Aagaard KM, McCurdy CE, Kievit P, Bergman BC, Jones KL, Pietras EM, Wesolowski SR, Friedman JE.

Cell Rep. 2023 Apr 13;42(4):112393. doi: 10.1016/j.celrep.2023.112393. Online ahead of print.PMID: 37058409 Free article.

Adaptive responses in uteroplacental metabolism and fetoplacental nutrient shuttling and sensing during placental insufficiency.

Kyllo HM, Wang D, Lorca RA, Julian CG, Moore LG, Wilkening RB, Rozance PJ, Brown LD, Wesolowski SR.

Am J Physiol Endocrinol Metab. 2023 Jun 1;324(6):E556-E568. doi: 10.1152/ajpendo.00046.2023. Epub 2023 Apr 26.PMID: 37126847

Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets.

White A, Stremming J, Brown LD, Rozance PJ.

J Dev Orig Health Dis. 2023 Jun;14(3):353-361. doi: 10.1017/S2040174423000090. Epub 2023 Apr 28.PMID: 37114757

Neonatal exposure to a neuroactive steroid alters low-frequency oscillations in the subiculum.

Fine-Raquet B, Manzella FM, Joksimovic SM, Dietz RM, Orfila JE, Sampath D, Tesic V, Atluri N, Covey DF, Raol YH, Jevtovic-Todorovic V, Herson PS, Todorovic SM.

Exp Biol Med (Maywood). 2023 Apr;248(7):578-587. doi: 10.1177/15353702231177009. Epub 2023 Jun 13.PMID: 37309730 Review.

EBNEO commentary: Platelet transfusions in neonates and brain development: The new frontier.

Sola-Visner M, Delaney C, Davenport P.

Acta Paediatr. 2023 Aug;112(8):1826-1827. doi: 10.1111/apa.16801. Epub 2023 May 1.PMID: 37128679 No abstract available.

Innate Immune Zonation in the Liver: NF-κB (p50) Activation and C-Reactive Protein Expression in Response to Endotoxemia Are Zone Specific.

McCarthy WC, Sherlock LG, Grayck MR, Zheng L, Lacayo OA, Solar M, Orlicky DJ, Dobrinskikh E, Wright CJ.

J Immunol. 2023 May 1;210(9):1372-1385. doi: 10.4049/jimmunol.2200900.PMID: 36946778

Maternal Western-style diet in nonhuman primates leads to offspring islet adaptations including altered gene expression and insulin hypersecretion.

Carroll DT, Elsakr JM, Miller A, Fuhr J, Lindsley SR, Kirigiti M, Takahashi DL, Dean TA, Wesolowski SR, McCurdy CE, Friedman JE, Aagaard KM, Kievit P, Gannon M.Am J Physiol Endocrinol Metab. 2023 Jun 1;324(6):E577-E588. doi: 10.1152/ajpendo.00087.2023. Epub 2023 May 3.PMID: 37134140

Acetaminophen for the patent ductus arteriosus: has safety been adequately demonstrated?

Wright CJ, McCulley DJ, Mitra S, Jensen EA.

J Perinatol. 2023 May 11. doi: 10.1038/s41372-023-01697-2. Online ahead of print.PMID: 37169914 Review.

RDS-NExT workshop: consensus statements for the use of surfactant in preterm neonates with RDS.

Bhandari V, Black R, Gandhi B, Hogue S, Kakkilaya V, Mikhael M, Moya F, Pezzano C, Read P, Roberts KD, Ryan RM, Stanford RH, Wright CJ.

J Perinatol. 2023 May 15. doi: 10.1038/s41372-023-01690-9. Online ahead of print.PMID: 37188774

Impact of Chorionic Somatomammotropin In Vivo RNA Interference Phenotype on Uteroplacental Expression of the IGF Axis.

Hord TK, Tanner AR, Kennedy VC, Lynch CS, Winger QA, Rozance PJ, Anthony RV.

Life (Basel). 2023 May 26;13(6):1261. doi: 10.3390/life13061261.PMID: 37374044 Free PMC article.

SIRT3 Is a Critical Regulator of Mitochondrial Function of Fibroblasts in Pulmonary Hypertension.

Li M, Plecitá-Hlavatá L, Dobrinskikh E, McKeon BA, Gandjeva A, Riddle S, Laux A, Prasad RR, Kumar S, Tuder RM, Zhang H, Hu CJ, Stenmark KR.

Am J Respir Cell Mol Biol. 2023 Jun 21. doi: 10.1165/rcmb.2022-0360OC. Online ahead of print.PMID: 37343939

Metformin Disrupts Signaling and Metabolism in Fetal Hepatocytes.

Swenson KS, Wang D, Jones AK, Nash MJ, O'Rourke R, Takahashi DL, Kievit P, Hennebold JD, Aagaard KM, Friedman JE, Jones KL, Rozance PJ, Brown LD, Wesolowski SR.

Diabetes. 2023 Jun 22:db230089. doi: 10.2337/db23-0089. Online ahead of print.PMID: 37347736

Chronic Fetal Leucine Infusion Increases Rate of Leucine Oxidation but Not of Protein Synthesis in Late Gestation Fetal Sheep.

Rozance PJ, Boehmer BH, Chang EI, Wesolowski SR, Brown LD.

J Nutr. 2023 Feb;153(2):493-504. doi: 10.1016/j.tjnut.2022.12.027. Epub 2022 Dec 30.PMID: 36894241

Re-examination of the estimated average requirement for carbohydrate intake during pregnancy: Addition of placental glucose consumption.

Hernandez TL, Rozance PJ.

Am J Clin Nutr. 2023 Feb;117(2):227-234. doi: 10.1016/j.ajcnut.2022.09.005. Epub 2022 Dec 19.PMID: 36811561 Review.