Publications using HIS-mice by PHISM:

Testing Cancer Immunotherapies:

  • Juan A. Marín-Jiménez1, Anna Capasso2, Matthew S. Lewis3, Stacey M. Bagby4, Sarah J. Hartman4, Jeremy Shulman3, Natalie M. Navarro4, Hui Yu5, Chris J. Rivard5, Xiaoguang Wang3, Jessica C. Barkow3, Degui Geng4, Adwitiya Kar6, Ashley Yingst7, Dejene M. Tufa7, James T. Dolan8, Patrick J. Blatchford9, Brian M. Freed3,10, Raul M. Torres3,5, Eduardo Davila4, Jill E. Slansky3,5, Roberta Pelanda3,5, S. Gail Eckhardt2, Wells A. Messersmith4,5, Jennifer R. Diamond4,5, Christopher H. Lieu4, Michael R. Verneris7, Jing H. Wang3,5, Katja Kiseljak-Vassiliades5,6, Todd M. Pitts4,5 and Julie Lang. 2021. Testing cancer immunotherapy in a human immune system mouse model: correlating treatment responses to human chimerism, therapeutic variables and immune cell phenotypes. Front Immunol. doi: 10.3389/fimmu.2021.PMID: 607282.

  • Capasso, A*, Lang J*, Pitts TM, Jordan KR, Lieu CH, Davis SL, Diamond JR, Kopetz S, Barbee J, Peterson J, Freed BM, Yacob BW, Bagby SM, Messersmith WA, Slansky JE, Pelanda R, and Eckhardt SG. 2019. Characterization of immune responses to anti-PD-1 mono and combination immunotherapy in hematopoietic humanized mice implanted with tumor xenografts. J Immunotherp Cancer 7(1):37. PMID: 30736857.

  • Lang J*, Capasso A*, Jordan KR, French JD, Kar A, Bagby SM, Barbee J, Yacob BW, Head LS, Tompkins KD, Freed BM, Somerset H, Clark TJ, Pitts TM, Messersmith WA, Eckhardt SG, Wierman ME, Leong S, and Kiseljak-Vassiliades K. 2020. Development of an Adrenocorticol Cancer Humanized Mouse Model to Characterize Anti-PD-1 Effects on Tumor Microenvironment. J Clin Endo Met 105(1):26. PMID: 31513709. 

  • Tentler J, Lang J, Capasso A, Kim DJ, Benaim E, Lee YB, Eisen A, Bagby SM, Hartman SJ, Yacob BW, Gittleman B, Pitts TM, Pelanda R, Eckhardt SG and Diamond JR. 2020. RX-5092, a Novel b-catenin Modulator, Potentiates the Efficacy of Immune Checkpoint Inhibitors in Preclinical Models of Triple-negative Breast Cancer. BMC Cancer 20(10):1063. PMID: 33148223.


Human Specific Virus:

  • Coleman CB,* Lang J,* Sweet LA, Smith NA, Freed BM, Pan Z, Haverkos B, Pelanda R, and Rocherford R. 2018. Epstein-Barr virus 2 infects T-cells and induces B-cell lymphomagenesis in a humanized mouse model. Journal of Virology. 10.1128:813-818. PMID: 30089703.


Human B Cell Biology:

  • Alves da Costa T, Peterson, J, Lang J, Shulman J, Liang X, Freed BM, Boackle SA, Lauzurica P, Torres RM and Pelanda R. 2021. Central human B cell tolerance manifests with a distinctive cell phenotype and is enforced via CXCR4 signaling in hu-mice. Proc Natl Acad Sci U S A. 2021 Apr 20;118(16):e2021570118. doi: 10.1073/pnas.2021570118. PMID: 33850015. 

  • Alves da Costa, T, Lang J, Torres RM and Pelanda R. 2019. The development of human immune system mice and their use to study tolerance and autoimmunity. J Transl Autoimmun. 2:100021. PMID: 32743507. 

  • Lang J, Zhang B, Kelly M, Peterson JN, Barbee J, Freed BM, Di Santo JP, Matsuda JL, Torres RM and Pelanda R. 2017. Replacing mouse BAFF with human BAFF increases human B cell numbers but not B cell maturation in humanized mice. Blood Advances.  1:2729-2741. PMID: 29296925. 
  • Lang J, Ota T, Kelly M, Strauch, P, Freed BM, Torres RM, Nemazee D and Pelanda R. 2016. Receptor Editing and genetic variability in human autoreactive B cells. J Exp Med 213(1):93-108. PMID: 26694971.
  • Lang J and Pelanda R. 2014. Human B-Cell Development in a Mouse Environment in Poluektova LY, Garcia-Martinez JV, Koyanagi Y, Manz MG, Tager AM, (Eds), Humanized Mice for HIV Research (pp141-152). New York, Heidelberg, Dordrecht, London: Springer. ISBN 978-1-4939-1654-2. 

  • Lang J, Kelly M, Freed BM, McCarter MD, Kedl RM, Torres RM, Pelanda R. 2013. Studies of lymphocyte reconstitution in a humanized mouse model reveal a requirement of T cells for human B cell maturation. J Immunol. 190(5):2090-101. PMID: 23335750.


General HIS-mice

  • Lang J, Weiss N, Freed BM, Torres RM and Pelanda R. 2011. Generation of hematopoietic humanized mice in the newborn BALB/c-Rag2-/-IL2r-/- mouse model: a multivariable optimization approach.  Clin. Immunol.  140(1):102-116. PMID: 21536497.
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