Rates and Fee Structures



Pre-clinical Human Immune System Mice Share Resource (PHISM) Services and Fee Structure for users within the CU system. Prices below are subsidized by the Human Immunology and Immunotherapy Dean’s Transformation Initiative (CU School of Medicine).  Further reduced rates are available for preliminary data that will be used in future grant applications, please inquire if your study qualifies.  

Users outside the CU system, please inquire about non-academic, non-subsidized pricing.


Initial Project SupportDiscussion of research project needs, a high-level view of experimental design and timeline, and associated analyses and servicesFree
Experimental Design SupportDesign of experiment including number of mice, treatments, time-course and flow cytometry panel design for analysis of Human Immune System mouse tissue$406


BRGS/NBSGWBRGS (BALB/c Rag2-/- IL2Rγ-/-  SIRPαNOD mice) or NBSGW (NOD.CgKitW41J Tyr+ Prkdcscid Il2rgtm1Wjl/ThomJ)$17 + cage cost
HIS-CB-BRGS Human Immune System mice generated from CD34+ HSC’s from cord blood at birth verified by two bleeds to be >25% human, >14 weeks$364/mouse
 With full flow immune analysis (tissue harvest and Stains A-D, see below)$1,394/mouse
 With customized flow immune analysisContact for pricing
HIS-PBMC BRGS Human Immune System mice generated from peripheral blood mononuclear cells (PBMC) from adult blood or cord blood and injected into adult BRGS immunodeficient mice. Human chimerism verified at 5-14 days post injection. Mice develop GVHD and should be used between 2-4 weeks and typically reconstitute with a predominant activated T cell population and approximately 10% B cells. Model is validated for Cytokine Release Syndrome assays testing inflammatory markers in blood following treatments.$261/mouse
HIS-FLT-BRGSHuman Immune System mice using CD34+ fetal liver (FL) hematopoietic stem cells (HSC) and co-implantation of matched thymus.  Human Immune System mice are verified for >25% human chimerism in blood.Contact for pricing
HIS-BM-BRGSHuman Immune System mice using CD34+ from bone marrow (BM) hematopoietic stem cells (HSC) at birth and verified for >5% human chimerism in bloodContact for pricing


Flow Time$150/hour
Antibody cost$4/sample or list price
Panel design and staining$133/hour + antibodies + flow time

Stain A (EC only)

(human immune subsets)


Stain B (EC only)

(HLA, inhibitor receptor expression on tumor and immune cells)


Stain C (IC)

Tregs, Tem/cm, Granzyme B


Stain D (IC)

Cytokies (IFNγ, TNFα)



HIS Mouse lymph node and spleen harvest$126/mouse
HIS Mouse Tissue (eg tumor, lung, liver) harvest$152/mouse
Tumor injections$12/mouse
Tumor measurement$12/mouse
Drug Dosing


CD34+ isolation from cord blood$1,029 per CB


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