When you take a medicine (or drug), your body needs to find a way to use it.  Some proteins in your body carry (transport) medicines so that they can be used.  If your body can’t carry a medicine to the right place, this may make the medicine not work as well.  It may also cause a side effect.

The ABCG2 gene gives instructions to your body to make a protein.  The ABCG2 protein helps carry the medicine, rosuvastatin, so your body can use it.  Rosuvastatin is used to help lower cholesterol. 

This is the medicine that we know of right now that is impacted by ABCG2 gene test results.  Medical experts keep finding new data about which medicines are affected by gene test results.

By testing your DNA, we can find DNA differences.  This can help us to see how well the proteins in your body work to carry different medicines. 

The results of your ABCG2 gene test will place you into 1 of 3 groups:

• Normal function: People in this group are likely to have normal working ABCG2 proteins. 
• Decreased function: People in this group may have reduced function of ABCG2 proteins. 
• Poor function: People in this group may have very little or no active ABCG2 protein. 

The results of this test can help your doctor choose the right medicine and dose for you.