TCAs Tip Sheet

The following information is intended for use by providers who are attempting to prescribe amitriptyline or nortriptyline to patients with certain CYP2D6 and CYP2C19 genetic variants.  

For immediate questions, send a secure chat message to Groups: "Pharmacogenomics Service" in UCHealth's EHR.


Patient Education Resources

Clinicians using the UCHealth EHR can use dotphrase: .pgxtcatopatient 

Reference: Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Müller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC. Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2017 Jul;102(1):37-44. doi: 10.1002/cpt.597. Epub 2017 Feb 13. PMID: 27997040; PMCID: PMC5478479.

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Tricyclic Antidepressants and CYP2C19/CYP2D6 Tip Sheet by Christina L. Aquilante is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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