Paroxetine/Venlafaxine/Vortioxetine Tip Sheet

The following information is intended for use by providers who are attempting to prescribe paroxetine, venlafaxine, or vortioxetine to patients with certain CYP2D6 genetic variants.

For immediate questions, send a secure chat message to Groups: "Pharmacogenomics Service" in UCHealth's EHR.

Patient Education Resources

Clinicians using the UCHealth EHR can use dotphrase: .pgxparoxetinetopatient, .pgxvenlafaxinetopatient, or .pgxvortioxetinetopatient

More Information for Your Patients

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Reference: Bousman CA, Stevenson JM, Ramsey LB, Sangkuhl K, Hicks JK, Strawn JR, Singh AB, Ruaño G, Mueller DJ, Tsermpini EE, Brown JT, Bell GC, Leeder JS, Gaedigk A, Scott SA, Klein TE, Caudle KE, Bishop JR. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants. Clin Pharmacol Ther. 2023 Jul;114(1):51-68. doi: 10.1002/cpt.2903. Epub 2023 May 30. PMID: 37032427.

SSRIs and CYP2C19/CYP2D6 Tip Sheets by Christina L. Aquilante is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. Based on a work at https://medschool.cuanschutz.edu/cobiobank/providers/results/pgx/ssris-tipsheets/paroxetine-vortioxetine-tipsheet.