Patient Education Resources
Clinicians using the UCHealth EHR can use dotphrase: .pgxirinotecantopatientIrinotecan Tip Sheet
The following information is intended for use by providers who are attempting to prescribe irinotecan to patients with certain UGT1A1 genetic variants.
For immediate questions, send a secure chat message to Groups: "Pharmacogenomics Service" in UCHealth's EHR.
References:
- Hulshof EC et al. Dutch pharmacogenetics working group (DPWG) guideline for the gene-drug interaction between UGT1A1 and irinotecan, Eur J Hum Genet. 2022 Nov 28 online ahead of print. PMID: 36443464.
- Irinotecan Onivyde prescribing information. https://www.ipsen.com/websites/Ipsen_Online/wp-content/uploads/sites/9/2019/01/21083350/ONIVYDE_USPI.pdf
- Díaz-Villamarín X, Nieto-Sánchez MT, Martínez-Pérez M, Novo-González P, Fernández-Varón E, Torres-García A, González Astorga B, Blancas I, Cabeza-Barrera J, Morón R. Dose-Limiting Toxicities and the Maximum Tolerated Dose of Irinotecan Based on UGT1A1 Genotypes: A Systematic Review. Pharmaceutics. 2025 Apr 22;17(5):542. PMID: 40430836.
Irinotecan and UGT1A1 Tip Sheet by Christina L. Aquilante is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Webpage updated as of: 4.1.26
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