Irinotecan Tip Sheet

The following information is intended for use by providers who are attempting to prescribe irinotecan to patients with certain UGT1A1 genetic variants.  


For immediate questions, send a secure chat message to Groups: "Pharmacogenomics Service" in UCHealth's EHR.

Patient Education Resources

Clinicians using the UCHealth EHR can use dotphrase: .pgxirinotecantopatient 


  1. Hulshof EC et al. Dutch pharmacogenetics working group (DPWG) guideline for the gene-drug interaction between UGT1A1 and irinotecan, Eur J Hum Genet. 2022 Nov 28 online ahead of print. PMID: 36443464.
  2. Irinotecan Onivyde prescribing information.
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