Patient Education Resources
Clinicians using the UCHealth EHR can use dotphrase: .pgxirinotecantopatient
Alert: Canvas Outage Update
Canvas access has been restored for our users, but the service reliability remains uncertain. Due to recent events, Canvas has had intermittent outages which are at the discretion of the vendor and may occur during a final exam. Faculty and staff may continue to use Canvas, but we strongly advise faculty and students to prepare a contingency plan for turning in assignments and final exams in the event Canvas access becomes unavailable again.
Instructure, the company that owns Canvas, has provided an FAQ about the incident, which may not answer all your questions. We will share more information if it becomes available.
Instructure, the company that owns Canvas, has provided an FAQ about the incident, which may not answer all your questions. We will share more information if it becomes available.
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Irinotecan Tip Sheet
The following information is intended for use by providers who are attempting to prescribe irinotecan to patients with certain UGT1A1 genetic variants.
For immediate questions, send a secure chat message to Groups: "Pharmacogenomics Service" in UCHealth's EHR.
References:
- Hulshof EC et al. Dutch pharmacogenetics working group (DPWG) guideline for the gene-drug interaction between UGT1A1 and irinotecan, Eur J Hum Genet. 2022 Nov 28 online ahead of print. PMID: 36443464.
- Irinotecan Onivyde prescribing information. https://www.ipsen.com/websites/Ipsen_Online/wp-content/uploads/sites/9/2019/01/21083350/ONIVYDE_USPI.pdf
- Díaz-Villamarín X, Nieto-Sánchez MT, Martínez-Pérez M, Novo-González P, Fernández-Varón E, Torres-García A, González Astorga B, Blancas I, Cabeza-Barrera J, Morón R. Dose-Limiting Toxicities and the Maximum Tolerated Dose of Irinotecan Based on UGT1A1 Genotypes: A Systematic Review. Pharmaceutics. 2025 Apr 22;17(5):542. PMID: 40430836.
Irinotecan and UGT1A1 Tip Sheet by Christina L. Aquilante is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Webpage updated as of: 4.1.26
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