A team led by Maria Natalia Vergara, Ph.D., Sue Anschutz-Rodgers Eye Center, University of Colorado is awarded $60,000 for developing an organoid derived from stem cells engineered to fluoresce which allows the organoid to demonstrate the cellular composition more clearly and efficiently. This advancement allows for improved organoid differentiation that can be used to screen and validate drugs more readily.
The advent of stem cell-derived retinal organoids has brought forth unprecedented opportunities for developmental and physiological studies, while presenting new therapeutic promise for retinal degenerative diseases.
The mouse retina comprises seven major cell types that exist in differing proportions. They are generated from multipotent progenitors in a stochastic manner, such that the relative frequency of any given type generated changes over time.
How retinal bipolar cell interneurons are specified and assigned to specialized subtypes is only partially understood. In part, this is due to a lack of early pan- and subtype-specific bipolar cell markers.