The research in Dr. Wyatt's laboratory is directed toward the understanding of airway epithelial cell function under physiologic and disease conditions. He is interested in the mechanistic signal transduction pathways that define ciliary beating, pro-inflammatory cytokine production, remodeling and wound repair, and cell adhesion under conditions of cigarette smoking and alcohol consumption. His studies aim to define the role of serine-threonine protein kinases and the second messengers that regulate these enzymes in lung epithelial function. Dr. Wyatt has extensive experience in animal models of alcohol consumption that are invaluable to establishing mechanistic investigations tested with CoPARC samples.