Drinking alcohol may be identified by means of validated tools such as the Alcohol Use Disorders Identification Test (AUDIT).
Epidemiologic data from 2014 indicate that 16.3 million adults suffer from AUDs in the US.
Risk factor for the development of Pneumonia
When pneumonia occurs in AUD patients, it is often complicated by extra-pulmonary disease such as the development of bacteremia, sepsis, and septic shock, with attendant poor outcomes.
Pneumonia is the most common cause of death from infectious disease in the US that imposes an economic burden of more than $17 billion annually.
Patients with AUDs having pneumonia or sepsis are at a two-fold increased risk of developing the acute respiratory distress syndrome (ARDS), characterized by the acute onset of non-cardiogenic pulmonary edema and respiratory failure requiring mechanical ventilation.
Risk factor for the development of Acute Respiratory Distress Syndrome (ARDS)
ARDS carries a mortality risk of 29-42%, and is responsible for 75,000 deaths annually in the US.
Patients with AUD-associated ARDS fare still more poorly, requiring prolonged hospitalizations and having a mortality of 59-65%.
For individuals with AUDs that decrease their predisposition for pneumonia, with the support of the National Institute on Alcoholism and Alcohol Abuse (NIAAA).
Readily Accessible Biorepository
Data and clinical samples from subjects with AUDs and controls.
Extend Our Resources
We hope to extend our resources to support the research in other organ systems that contribute to critical illness in these individuals.
Hope to improve understanding of the pathophysiologic mechanisms contributing to increased morbidity in pneumonia and ARDS among patients with AUDs, as these conditions are of substantial public health importance.
Access to a biorepository of specimens/data from:
Otherwise healthy participants with either alcohol abuse and dependence, or chronic cannabis use, and matched controls.
Cigarette smoking and cannabis smoking histories are collected from all subjects and controls.
Mechanically ventilated patients with respiratory failure from pulmonary conditions including pneumonia, ARDS, and COVID-19, including patients with and without an AUD history.
Patients with severe burn injuries, including inhalation injury, including patients with and without an AUD history.
Facilitate collaboration
With a consortium of investigators with basic and clinical research experience in the field of alcohol-related pulmonary diseases to aid in experimental designs and extend investigative projects.