An AUD is diagnosed when problem drinking becomes severe, and may be identified by means of validated tools including the Alcohol Use Disorders Identification Test (AUDIT). Epidemiologic data from 2014 indicate that 16.3 million adults suffer from
AUDs in the US. AUDs have a major impact on the development of pneumonia, the most common cause of death from infectious disease in the US that itself imposes an economic burden of more than $17 billion annually. AUDs are a definite
risk factor for the development of pneumonia, and when pneumonia occurs in these patients, it is often complicated by extra-pulmonary disease, including development of bacteremia, sepsis, and septic shock, with attendant poor outcomes. Notably,
patients with AUDs having pneumonia or sepsis are at a two-fold increased risk of developing the acute respiratory distress syndrome (ARDS), characterized by the acute onset of non-cardiogenic pulmonary edema and respiratory failure
requiring mechanical ventilation. ARDS carries a mortality risk of 29-42%, and is responsible for 75,000 deaths annually in the US. Analogous to outcomes in AUD-associated pneumonia, patients with AUD-associated ARDS fare still more poorly, requiring
prolonged hospitalizations and having a mortality of 59-65%. Therefore, Colorado Pulmonary Alcohol Research Collaborative (CoPARC) investigations hope to improve understanding of the pathophysiologic mechanisms contributing to increased morbidity
in pneumonia and ARDS among patients with AUDs, as these conditions are of substantial public health importance. To develop new interventions for individuals with AUDs that decrease their predisposition for pneumonia, with the support of the National
Institute on Alcoholism and Alcohol Abuse (NIAAA), we have developed CoPARC to conduct translational investigations to complement and extend basic science observations. The goal of CoPARC is to serve as a readily accessible biorepository of data
and clinical samples from subjects with alcohol use disorders and controls. While our primary focus is on pulmonary processes affected by alcohol, we hope to extend our resources to support the research in other organ systems that contribute to
critical illness in these individuals.