Special Exceptions to the Use of Pharmacogenetic Test Results
Pharmacogenetic results should NOT be used for clinical decision-making if the patient has undergone an allogeneic bone marrow transplant or liver transplant.
If a patient's blood sample was drawn for genotyping after allogeneic bone marrow transplant, the pharmacogenetic results reflect the donor's DNA and may NOT accurately reflect the patient's (recipient's) DNA.
Pharmacogenetic results obtained from a blood sample in patients who have undergone liver transplantation may not accurately reflect the patient's liver genotype. The donor liver may have an alternate genotype than the patient's (recipient's) blood. This is particularly important since the majority of pharmacogenetics is focused on genetic variants in cytochrome P450 in the liver.